DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8086 and Nup98

DIOPT Version :9

Sequence 1:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster
Sequence 2:	NP_001274093.1	Gene:	Nup98 / 269966	MGIID:	109404	Length:	1816	Species:	Mus musculus

Alignment Length:	1023	Identity:	209/1023 - (20%)
Similarity:	309/1023 - (30%)	Gaps:	339/1023 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 PSETPAPGAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLDHTPAYSFGGKNDPK 723
            |:.:.|.|.:|....    |.||:..   ..|...||...|        ....|...||.:|...
Mouse   232 PATSSATGLFSSSTT----NSAFSYG---QNKTAFGTSTTG--------FGTNPGGLFGQQNQQT 281

  Fly   724 VE---------NNTPAPGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTPAPGAYSPEKVRQ----- 774
            ..         ..||              |..:||.....|.:|| |...|.:...:..|
Mouse   282 TSLFSKPFGQATTTP--------------NTGFSFGNTSTLGQPS-TNTMGLFGVTQASQPGGLF 331

  Fly   775 --------------------DHNPAFSMAGKPV---EKL----TNGTPAP------GDYSPEKVR 806
                                ..|..|...|..:   .||    |:.|.||      |.....|..
Mouse   332 GTATNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFGNKPT 396

  Fly   807 L-----NHTPAYTFGGKND-PKVENNTPAPGDYHPEKVRQDHNPAFSF---AGRHDLHKPND--- 859
            |     .:|..:.||..|. ..:..:.||.|     .:.......|..   ||:..|...|.
Mouse   397 LTLGTNTNTSNFGFGTNNSGSSIFGSKPAAG-----TLGTGLGTGFGTALGAGQASLFGNNQPKI 456

  Fly   860 -----TPAPGAYCPEKVRQDHNPAFSMA------GKYTQKVANDTPAPGDYSPEKVRLDHTPAYT 913
                 |.|.||           |.|:.:      |.....||...| ....:.:.|...|..:.|
Mouse   457 GGPLGTGAFGA-----------PGFNTSTAILGFGAPQAPVALTDP-NASAAQQAVLQQHLNSLT 509

  Fly   914 FGGKNDPKVESNTPAPGDYHPEKVRQDHNPAFSFAGRHNLQKPSD---TPAPGAYSPEKVRQDHN 975
            :....|..:..| |.......|:..:..|||...|    |..|:.   ||.|......|..|...
Mouse   510 YSPFGDSPLFRN-PMSDPKKKEERLKPTNPAAQKA----LTTPTHYKLTPRPATRVRPKALQTTG 569

  Fly   976 PA----FTMAGKHDPKVSNDTPAPGDYSPEK-----VRLDYTPSFTFAGKNNPKVENDTPAPGDY 1031
            .|    |......:|.::|     |.:.|:|     |..:...|..|:..|:.  ..|..:|.:|
Mouse   570 TAKSHLFDGLDDDEPSLAN-----GAFMPKKSIKKLVLKNLNNSNLFSPVNHD--SEDLASPSEY 627

  Fly  1032 HPEKVRQDHNPAFSFAGRHDLHKPSDTPAPGAYSPEKVRQDHNPAFSMAGKYIEKITNGTPAPGD 1096
             ||     :...|||     |.||.|         |..:||.... |:..::   .||....|..
Mouse   628 -PE-----NGERFSF-----LSKPVD---------ENNQQDGEDD-SLVSRF---YTNPIAKPIP 668

  Fly  1097 YCPEKVRLDHTPAFTFGGKND--PKVENNTPA----------------PGDYHPEKVRQD----- 1138
            ..||.|          |.||:  ..||:...|                ...:|.|.::.|
Mouse   669 QTPESV----------GNKNNSSSNVEDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIE 723

  Fly  1139 ----HV-PA---------FSFAGRHDLHK-PNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTH 1188
                |: ||         ::.....||.| .||       ..|.:..|    ||:..|....:..
Mouse   724 NNAYHIHPAGIVLTKVGYYTIPSMDDLAKITNE-------KGECIVSD----FTIGRKGYGSIYF 777

  Fly  1189 DTPAPGDYHPEKVRLD-----------------HNPAFSFAGRHDLHKPSETPAPGDYFPEKVRQ 1236
            :    ||.:...:.||                 ..|...    ..|::.:|....|.:..:|..:
Mouse   778 E----GDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVG----EGLNRKAEVTLDGVWPTDKTSR 834

  Fly  1237 ----------DFNPAFTFAGKHDPRSLSESPAPGDYSPEK----VRLDHAPAFSFGG-------- 1279
                      |.|    :.|:.:..|..:.....:|.||.    .::.|   ||..|
Mouse   835 CLIKSPDRLADIN----YEGRLEAVSRKQGAQFKEYRPETGSWVFKVSH---FSKYGLQDSDEEE 892

  Fly  1280 -KHDPKT--EHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQ----CQVDS 1337
             :|.|||  :.|..||...|.:..    |...|:.|:||....||:|     ..||    .::||
Mouse   893 EEHPPKTTSKKLKTAPLPPAGQAT----TFQMTLNGKPAPPPQSQSP-----EVEQLGRVVELDS 948

  Fly  1338 TPAFTFGMRLGRERISDT----PAPSAYEPEKHSLHSTPAYSFG--------TKSDIRV---TTD 1387
            ..     :.:.:|.:.|:    ..|...||...|.|.  |.|.|        .|:.:.|   ..|
Mouse   949 DM-----VDITQEPVPDSVLEESVPEDQEPVSASTHI--ASSLGINPHVLQIMKASLLVDEEDVD 1006

  Fly  1388 A--------PAPGHYHPEQC--KLDSSPAYSFGLKTVPTASLPEPRGAYIEDRIVQRRERRLASP 1442
            |        |:.|....|.|  :|..|.::|...:::.        |..::.:..   .....||
Mouse  1007 AMDQRFGHIPSKGETVQEICSPRLPISASHSSKSRSIV--------GGLLQSKFA---SGTFLSP 1060

  Fly  1443 VRNNAECTTTTTNHTNNNAGSSTTTTTTTTTTTKTFINGVEQPELQKK 1490
            ..:..||.|..|:...|...:|..:......|..|..:  ..||:|.|
Mouse  1061 SASVQECRTPRTSSRMNIPSTSPWSVPLPLATVFTVPS--PAPEVQLK 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8086	NP_001260237.1	None
Nup98	NP_001274093.1	FG repeats 1	1..156
		Nucleoporin_FG	40..149	CDD:372653
		GLEBS, interaction with RAE1. /evidence=ECO:0000250	157..213
		FG repeats 2	214..480		56/293 (19%)
		Nucleoporin_FG	239..332	CDD:372653	24/122 (20%)
		Nucleoporin_FG	329..466	CDD:372653	26/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..535		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..682		7/28 (25%)
		Nucleoporin2	740..880	CDD:367810	27/165 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..937		16/59 (27%)
		Nup96	1333..1622	CDD:371903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030