DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8086 and Nup62

DIOPT Version :9

Sequence 1:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster
Sequence 2:	NP_444304.1	Gene:	Nup62 / 18226	MGIID:	1351500	Length:	526	Species:	Mus musculus

Alignment Length:	424	Identity:	90/424 - (21%)
Similarity:	140/424 - (33%)	Gaps:	107/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1209 FSFAGRHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPG-DYSPEKVRLDHA 1272
            |:|.|       :..||.|              |||.   ..::.:.:||.| .:|....   ..
Mouse     4 FNFGG-------TGAPAGG--------------FTFG---TAKTATTTPATGFSFSASGT---GT 41

  Fly  1273 PAFSFGGKHDPKTEHLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAPCDYHPEQCQVDS 1337
            ..|:||....|...                  ||:.::.........:|||.        ....:
Mouse    42 GGFNFGTPSQPAAT------------------TPSTSLFSLTTQTPTTQTPG--------FNFGT 80

  Fly  1338 TPA-----FTFGMRLGRERISDTPA-PSAYEPEKHSLHS---TPAYSFGTKSDIRV--------- 1384
            |||     |:.|:...:..:|:..| |:........|.|   |.|.|.|:.|:...
Mouse    81 TPASGGTGFSLGISTPKLSLSNAAATPATANTGSFGLGSSTLTNAISSGSTSNQGTAPTGFVFGS 145

  Fly  1385 -TTDAPAPGHYHPEQCKLDSSPAYSFGLKTVPTASLPEPRGAYIEDRIVQRRERRLASPVRNNAE 1448
             ||.||:.|           |..:||   |..:||.|...|..:.......:...|:......|.
Mouse   146 STTSAPSTG-----------STGFSF---TSGSASQPGASGFSLGSVGSSAQPTALSGSPFTPAT 196

  Fly  1449 CTTTTTNHTNNNAGSSTTTTTTTTTT---------TKTFINGVEQPELQKKETTKQVNGTHKELK 1504
            ..|||...|...|.:.|..||:..:|         ..:...|:..|.......|.........||
Mouse   197 LVTTTAGATQPAAAAPTAATTSAGSTLFASIAAAPASSSATGLSLPAPVTTAATPSAGTLGFSLK 261

  Fly  1505 SAPQAPLSNGNIVSNGNHSKMVSTTTRIQEVAHGQKESG---NLK-VVASGKSDASATKAAAVSH 1565
            :...||.::    :....:...:|||.....|.....:|   :|| :|::|.|..:|| |...|.
Mouse   262 APGAAPGAS----TTSTTTTTTTTTTTAAAAAASTTTTGFALSLKPLVSAGPSSVAAT-ALPASS 321

  Fly  1566 QTVVQADGAIVTSGQSSRMQTVKYAVEASSVQEK 1599
            .....|.|..:|..|...:.. |:::|... ||:
Mouse   322 TAAGTATGPAMTYAQLESLIN-KWSLELED-QER 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8086	NP_001260237.1	None
Nup62	NP_444304.1	5 X 2 AA repeats of F-G. /evidence=ECO:0000250\|UniProtKB:P37198	6..144		36/190 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..82		9/64 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..148		2/19 (11%)
		Nsp1_C	318..433	CDD:282867	9/38 (24%)
		Required for centrosome localization. /evidence=ECO:0000250\|UniProtKB:P37198	332..462		6/24 (25%)
		DUF4795	366..>505	CDD:292662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030