DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8086 and Rere

DIOPT Version :9

Sequence 1:	NP_001260237.1	Gene:	CG8086 / 34131	FlyBaseID:	FBgn0032010	Length:	1603	Species:	Drosophila melanogaster
Sequence 2:	XP_008762420.1	Gene:	Rere / 116665	RGDID:	629475	Length:	1567	Species:	Rattus norvegicus

Alignment Length:	1403	Identity:	281/1403 - (20%)
Similarity:	411/1403 - (29%)	Gaps:	439/1403 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 YCPEKVKLNKTP-EFSFGIKHHEQRPDYTPAPGTYKPE-QVVLEH-----IPAYSFGLKTKHIQV 296
            |.||..:||.|. |...|..|..:.||..|.|   .|: ..|.:|     :|..|......:::.
  Rat   271 YNPETRRLNSTQGEIRVGPSHQAKLPDLQPFP---SPDGDTVTQHEELVWMPGVSDCDLLMYLRA 332

  Fly   297 SDTPA------------PGAYSPEK--------SRLHSAPAYSIAGKASQDVVDCTPAPGAYEPE 341
            :.:.|            .|..:..:        :.||.: :|. ||||.|.:|. .|.|...  |
  Rat   333 ARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHES-SYD-AGKALQRLVK-KPVPKLI--E 392

  Fly   342 KC-----------VLSRTPAFSFGHRAELAKSSDTPAPGTY------NPEKV------RLDHTPA 383
            ||           .|.:.....|..|.||..:.:|....|:      .||..      |......
  Rat   393 KCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAV 457

  Fly   384 FTLSGRPETRSVS---ETPAPGSYAPEKYRNDRTPAFTFGGKHEQRLESSTPAPGDYCPEKVRHD 445
            |.   |.:||:.|   .||:            |.|:..|       |:.|:.:..|:..|....:
  Rat   458 FR---RIKTRTASTPVNTPS------------RPPSSEF-------LDLSSASEDDFDSEDSEQE 500

  Fly   446 HNPAFSFAGRHDLHKPSDTPAPGAYDTEKVRQDHNPAFSFAGR-HDLHKPSETPAPGAYSPEKVR 509
            ..   .:|.||.....|.....|..:...:..|....|...|. ..:.||.: |.|..:.|.|..
  Rat   501 LK---GYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVD-PPPFMFKPVKEE 561

  Fly   510 QDHNPAFSMAGKHSQK----------------------------VTSDSPAPGDYCPEKVRLDHT 546
            .|     .::||||.:                            |..|..:.|...|........
  Rat   562 DD-----GLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPVNEDVRSSGRNSPSAASTSSN 621

  Fly   547 PAYSFGV-KSDPKVENNTPAP---GDYHPEKVRQDHNPAYSFAGR----HDLQKPDNTPAPGAYF 603
            .:.:..| ||..||:....:|   .....|||..|.........:    .::.:| |:|:.|.
  Rat   622 DSKAEAVKKSAKKVKEEAASPLKNTKRQREKVASDTEDTDRATSKKTKTQEISRP-NSPSEGE-- 683

  Fly   604 PEKVRLDHNPAFSMAGKYDAKVTNDTPAPGDYSPEKVRQD---TNPAYSFAGRHDLHKPSETPAP 665
                          ....|::..||   .|...|:.:.||   |:|:        :..|.:..:.
  Rat   684 --------------GESSDSRSVND---EGSSDPKDIDQDNRSTSPS--------IPSPQDNESD 723

  Fly   666 GAYSPEKVRLDHNPAFTMAGKHDQKILNGTPAPGDYSPEKCRLDHTPAYSFGGKNDPKVENNTPA 730
            ...|.::..|...|....|..      ....||....|...:|. ||             ..||:
  Rat   724 SDSSAQQQMLQTQPPALQAPS------GAASAPSTAPPGTTQLP-TP-------------GPTPS 768

  Fly   731 PGDYHPEKVRLDHNPAYSFAGRHDLQKPSDTP---APGAYS---------PEKVRQDHNPAFSMA 783
            .....|:     .:||.|       |.|:.|.   ||.|::         |.::...|.|...|.
  Rat   769 ATTVPPQ-----GSPATS-------QPPNQTQSTVAPAAHTLIQQTPTLHPPRLPSPHPPLQPMT 821

  Fly   784 GKPVEKLTNGTPAP-----GDYSPEKVR----LNHT-PAYTFGGKNDPKVENNT----PAPGDYH 834
            ..|.:......|.|     |...|..::    |.|. |...||  ..|:.....    |:|...|
  Rat   822 APPSQNSAQPHPQPSLHGQGPPGPHSLQTGPLLQHPGPPQPFG--LTPQSSQGQGPLGPSPAAAH 884

  Fly   835 PEKVRQDHNPAFSFAGRHDLHKPNDTPAPGAYCPEKVRQDHNPAFSMAGKYTQKVANDTPAPGDY 899
            |....|  .|| |.:.......|.:.|.|    |..:...|           .|....||.|...
  Rat   885 PHSTIQ--LPA-SQSALQPQQPPREQPLP----PAPLAMPH-----------IKPPPTTPIPQLP 931

  Fly   900 SPEKVRLDHTPAYTFGGKNDPKVESNTPAPGDYHPEKVRQDHNPAFSFAGRHNLQKPSDTPAPGA 964
            :|:..:  |.|  ...|.:...:.:|.|.|....|......|:|            ||..|.|..
  Rat   932 APQAHK--HPP--HLSGPSPFSMNANLPPPPALKPLSSLSTHHP------------PSAHPPPLQ 980

  Fly   965 YSPEKVRQDHNPAFTMAGKHDPKV--SNDTPAPGDYSPEKVRLDYTPSFTFAGKNNPKVENDTPA 1027
            ..|:......:||      ..|.:  |...|.|....|....|...||             .:|.
  Rat   981 LMPQSQPLPSSPA------QPPGLTQSQSLPPPAASHPTTGGLHQVPS-------------QSPF 1026

  Fly  1028 PGDYHPEKVRQDHNPAFSFAGRHDLHKPS----DTPAPGAYSPEKVRQDHNPAFSMAGKYIEKIT 1088
            |  .||          |...|...:..||    .||..|..|..:      |..|.|      ::
  Rat  1027 P--QHP----------FVPGGPPPITPPSCPPTSTPPAGPSSSSQ------PPCSAA------VS 1067

  Fly  1089 NGTPAPG-DYCPEKVRLDHTPAFTFGGKNDPKVENNTPAPGDYHPEKVRQDHVPAFSFAGRHDLH 1152
            :|...|| ..||       .||...  |.:...|...|
  Rat  1068 SGGNVPGAPSCP-------LPAVQI--KEEALDEAEEP--------------------------- 1096

  Fly  1153 KPNETPAPGAYSPEKVRQDHNPAFTMAGKHDPKVTHDTPAPGDYHPEKVR----LDHNPAFSFAG 1213
               |:|.|...||..               :|.|. |||:   :..:..|    ||.  .::...
  Rat  1097 ---ESPPPPPRSPSP---------------EPTVV-DTPS---HASQSARFYKHLDR--GYNSCA 1137

  Fly  1214 RHDLHKPSETPAPGDYFPEKVRQDFNPAFTFAGKHDPRSLSESPAPGDYSPEKVR---------L 1269
            |.||:   ..|..|....:|..:....|     |.:....:......:...||.|         .
  Rat  1138 RTDLY---FMPLAGSKLAKKREEAIEKA-----KREAEQKAREEREREKEKEKEREREREREREA 1194

  Fly  1270 DHAPAFSFGGKH-----DPKTE---HLHPAPCDYAPEKVRLDHTPAYTIAGRPAADHVSQTPAP- 1325
            :.|...:....|     ||:..   |:.|:   :.|....:...|.|.....||...:|:...|
  Rat  1195 ERAAQKASSSAHEGRLSDPQLSGPGHMRPS---FEPPPTTIAAVPPYIGPDTPALRTLSEYARPH 1256

  Fly  1326 -----CDYHPEQCQVDST-PAFTFGM---------------------------RLGRERISDTPA 1357
                 ...||....::.| |...:.|                           |..|||:.  |.
  Rat  1257 VMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMK--PG 1319

  Fly  1358 PSAYEPEKHSLH--STPAYSFGTKSDIRVTTDA-PAP-GHYHPEQCKLDSSPAYSFGLKTVPTAS 1418
            .....||...||  :.|...|...|.:.:...| |.| ..:||....|:.......|.:..|..|
  Rat  1320 FEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMS 1384

  Fly  1419 LPEPRGAYIEDRIVQRRERRLASPVRNNAECTTTTTNH 1456
            .|:...|   :||...|...|.|......:....|.:|
  Rat  1385 YPDRLAA---ERIHAERMASLTSDPLARLQMFNVTPHH 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8086	NP_001260237.1	None
Rere	XP_008762420.1	BAH_MTA	101..306	CDD:240060	14/37 (38%)
		ELM2	285..335	CDD:279754	11/52 (21%)
		SANT_MTA3_like	394..439	CDD:212559	8/44 (18%)
		SANT	395..440	CDD:197842	7/44 (16%)
		ZnF_GATA	502..551	CDD:214648	10/52 (19%)
		ZnF_GATA	505..559	CDD:238123	13/54 (24%)
		Atrophin-1	567..1566	CDD:281189	208/1068 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000