DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and CD22

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	924	Identity:	187/924 - (20%)
Similarity:	296/924 - (32%)	Gaps:	315/924 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 SRDENRIFASQSRTD---PKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRI 430
            |..:.::.:.|.|..   .|.:|       .||::.....:|:|.........:.:.::|.
Human    79 STKDGKVPSEQKRVQFLGDKNKN-------CTLSIHPVHLNDSGQLGLRMESKTEKWMERI---- 132

  Fly   431 KVLKQNESYLNVGE-PSGHY-----NVQEYANRTIQMTANFE--GFPTPSFSWFKPDGTEVRQ-- 485
                    :|||.| |...:     .:||....|:....||.  |:|. ...|.. :|..:||
Human   133 --------HLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPI-QLQWLL-EGVPMRQAA 187

  Fly   486 --------------SENNFKILSTELSTMLQVLNAQLQDS-GTYVLRGSNSFGVVQREYNVSVMD 535
                          ||..|   |.:.|...:::..||||: |.::   ||.  .||    ::|..
Human   188 VTSTSLTIKSVFTRSELKF---SPQWSHHGKIVTCQLQDADGKFL---SND--TVQ----LNVKH 240

  Fly   536 APALKM----SDAYVQVGSVARLECTVRSYPP--AIVTFFFRPCSLEPQWPTCSVLNQNFSLPSE 594
            .|.|::    |||.|:.|....:.|.|.|..|  ..|::.....||:.|  ....||.......:
Human   241 TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ--NTFTLNLREVTKDQ 303

  Fly   595 QEKY--QFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENM 657
            ..||  |......||: |.|...:|.:.| ||..:..:....::|.:
Human   304 SGKYCCQVSNDVGPGR-SEEVFLQVQYAP-EPSTVQILHSPAVEGSQ------------------ 348

  Fly   658 TIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHIT 722
                            |.|.|.:||.....|..|:.||::::...             :..|||.
Human   349 ----------------VEFLCMSLANPLPTNYTWYHNGKEMQGRT-------------EEKVHIP 384

  Fly   723 TISDRDRGTYEC----------RAYHNDKDAVYSSREIDLYVHDP-----------------SAP 760
            .|.....|||.|          |....:.|..|..:::...:.:|                 |.|
Human   385 KILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNP 449

  Fly   761 -----QW-TNGGQE----GHSKIKRKLSQTLELECA------STAVPVAI----------VRWFK 799
                 :| .:|..|    |..||:........:.||      |.|.|||:          ||..|
Human   450 SVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIK 514

  Fly   800 DDKEVTE----------------------SKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDR 842
            ...|:..                      .|...::.|||:|....:.|.|.|.|.|.|.|.:.:
Human   515 PLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQ 579

  Fly   843 IERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVG 907
            .             .|.||.                |.|.|.   .|.|.:..:......||...
Human   580 T-------------ASKAWT----------------LEVLYA---PRRLRVSMSPGDQVMEGKSA 612

  Fly   908 HI------NPDLT----LDEQAELLPYNREFEFPRENLKLGKQLGAGAF---GVVLKGEAKGIRR 959
            .:      ||.::    .|...:.|||:.:    :..|:..|...:||:   |....|:.:
Human   613 TLTCESDANPPVSHYTWFDWNNQSLPYHSQ----KLRLEPVKVQHSGAYWCQGTNSVGKGR---- 669

  Fly   960 EEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRF 1024
             .|.:|:.|.....|....|...|.|.|.|::     |.:..|  .:.:...:.:....::....
Human   670 -SPLSTLTVYYSPETIGRRVAVGLGSCLAILI-----LAICGL--KLQRRWKRTQSQQGLQENSS 726

  Fly  1025 GNIQNFLLRNRK--------------CFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKY 1075
            |  |:|.:||:|              |:    ||            .|.|           |:.|
Human   727 G--QSFFVRNKKVRRAPLSEGPHSLGCY----NP------------MMED-----------GISY 762

  Fly  1076 ANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYS--YDRQMDTCATVMTT 1138
            ..:.||   .:|.|           |..|.:.....|.......|.|||  :.||:.....|:..
Human   763 TTLRFP---EMNIP-----------RTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPD 813

  Fly  1139 VPEDDQIMSNNSVQ 1152
            .|||:.|..:..:|
Human   814 FPEDEGIHYSELIQ 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	10/65 (15%)
		Ig	<363..432	CDD:299845	10/65 (15%)
		Ig	466..533	CDD:299845	20/85 (24%)
		IG_like	672..754	CDD:214653	20/91 (22%)
		Ig	674..739	CDD:143165	18/74 (24%)
		IGc2	779..840	CDD:197706	23/98 (23%)
		PKc_like	927..1332	CDD:304357	49/245 (20%)
		Pkinase_Tyr	935..1329	CDD:285015	49/237 (21%)
CD22	NP_001762.2	Ig	24..122	CDD:299845	9/49 (18%)
		C2-set_2	143..228	CDD:285423	21/89 (24%)
		I-set	242..327	CDD:254352	24/87 (28%)
		IGc2	257..316	CDD:197706	14/60 (23%)
		Ig_3	335..400	CDD:290638	18/111 (16%)
		IG_like	343..415	CDD:214653	19/118 (16%)
		IG_like	433..501	CDD:214653	15/67 (22%)
		I-set	510..589	CDD:254352	20/107 (19%)
		IGc2	521..578	CDD:197706	12/56 (21%)
		IG_like	606..677	CDD:214653	16/79 (20%)
		IGc2	608..666	CDD:197706	13/61 (21%)
		ITIM motif 1	760..765		1/4 (25%)
		ITIM motif 2	794..799		3/4 (75%)
		ITIM motif 3	820..825		1/4 (25%)
		ITIM motif 4	840..845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000