DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Tie1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_445997.1	Gene:	Tie1 / 89806	RGDID:	621642	Length:	1137	Species:	Rattus norvegicus

Alignment Length:	997	Identity:	233/997 - (23%)
Similarity:	365/997 - (36%)	Gaps:	309/997 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PSGHYNVQ--------EYANRTIQMTANF----------EGFPTP---SFSWFKPDGTEVRQSEN 488
            |||.:.|.        :..|...::..|.          .|.|.|   |....|||||
  Rat   337 PSGWHGVHCEKSDRIPQILNVATELEFNLGTMPRINCAAAGNPFPVRGSMELRKPDGT------- 394

  Fly   489 NFKILSTE-------LSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV------MDAPAL- 539
              .:|||:       .:...:|....|.|||.:..|.|.|.|...|.:.|:|      :.||.|
  Rat   395 --MLLSTKAIVEPDRTTAEFEVPRLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLL 457

  Fly   540 -KMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSV-LNQNFSLPSEQEKYQFQT 602
             |.|...|    |:.|.......|.:.|...:||......|....| .::|.:|        ...
  Rat   458 AKQSRQLV----VSPLVSFGGDGPISSVRLHYRPQDSMITWSAIVVDPSENVTL--------MNL 510

  Fly   603 RPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKE-------RRTLTKAHVLLGNISENMTIY 660
            :||.|       |.|....:.||          :|.|       ..|......||....|:..:.
  Rat   511 KPRTG-------YNVRVQLSRPG----------EGGEGAWGPSTLMTTDCPEPLLQPWVESWNVE 558

  Fly   661 GFDKDHKIAKEDNVNFTCEALAYHFDGNL--KW-FINGEDLKESDSVHIETSHTKYSYKSTVHIT 722
            |.|:       ..|:::..::....||.|  .| ...|::.:|    :|.:...:     |..:|
  Rat   559 GPDR-------LRVSWSLPSVPLSGDGFLLRLWDGARGQERRE----NISSPQAR-----TALLT 607

  Fly   723 TISDRDRGTYECRAYH------------------------NDKDAVYSSREIDLYVHDPSA---- 759
            .::.......:.|.||                        :.:....|..||.|....|.|
  Rat   608 GLTPGTHYQLDVRLYHCTLLGPASPSAHVHLPLSGPPAPRHLRAQALSDSEIRLMWQHPEAPPGP 672

  Fly   760 ----------------PQWTNGGQ-EGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTES 807
                            |||.:..: |..|...|.|:.:........|....:..|   ...|.|:
  Rat   673 ISKYIVEIQVAGGSGDPQWMDVDKPEETSTTVRGLNASTRYLFRVRASVQGLGDW---SNTVEET 734

  Fly   808 KLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLIL 872
            .|.:.::..|        |..|   ..|.|:.||:     .:|::.:..:|       .....||
  Rat   735 TLGNGLQSAS--------PVQE---SRVAEDGLDQ-----QLVLAVVGSVS-------ATCLTIL 776

  Fly   873 IGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFP---REN 934
            ..|...:.:|....|:||.....:|  :.||..:...:..|||..:.:  |......:|   .|:
  Rat   777 AALLALVCIRRSCLHRRHTFTYQSG--SGEETILQFSSGTLTLTRRPK--PQPEPLSYPVLEWED 837

  Fly   935 LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNV 999
            :.....:|.|.||.|::..   |:::......|:||:|..|.....|....||:::..||.|.|:
  Rat   838 ITFEDLIGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI 899

  Fly  1000 VNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYEL 1064
            :|||||...   :..|.:.:||..:||:.:||.::|
  Rat   900 INLLGACEN---RGYLYIAIEYAPYGNLLDFLRKSR----------------------------- 932

  Fly  1065 HRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQM 1129

  Rat   933 ----------------------------------------------------------------- 932

  Fly  1130 DTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVL 1194
                     |.|.|         ||:...:.|    |.|:::..|:.:|...|.||.|||.|:.:
  Rat   933 ---------VLETD---------PAFAREHGT----ASTLSSRQLLRFASDAANGMQYLSEKQFI 975

  Fly  1195 HGDLAARNILLCEDNVVKICDFGLARSMYRGDN-YKKSENGKLPIKWLALESLSDHVFSTYSDVW 1258
            |.||||||:|:.|:...||.||||:    ||:. |.|...|:||::|:|:|||:..|::|.||||
  Rat   976 HRDLAARNVLVGENLASKIADFGLS----RGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW 1036

  Fly  1259 SYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFA 1323
            |:|::|||:.||...||.|: ...||:.||..|||||:|:..:.|:||:|.:|||..|..||.||
  Rat  1037 SFGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFA 1100

  Fly  1324 ELEKRFANMLGEDVASHYLDLN 1345
            ::..:...||  :....|::::
  Rat  1101 QIALQLGRML--EARKAYVNMS 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	23/76 (30%)
		IG_like	672..754	CDD:214653	17/108 (16%)
		Ig	674..739	CDD:143165	13/91 (14%)
		IGc2	779..840	CDD:197706	10/60 (17%)
		PKc_like	927..1332	CDD:304357	115/408 (28%)
		Pkinase_Tyr	935..1329	CDD:285015	113/394 (29%)
Tie1	NP_445997.1	ig	130..211	CDD:278476
		EGF_Lam	228..266	CDD:238012
		EGF_CA	315..346	CDD:238011	4/8 (50%)
		ig	357..442	CDD:278476	23/93 (25%)
		IG_like	370..444	CDD:214653	23/82 (28%)
		fn3	450..530	CDD:278470	24/108 (22%)
		fn3	549..631	CDD:278470	16/97 (16%)
		FN3	643..735	CDD:238020	17/94 (18%)
		PTKc_Tie1	835..1131	CDD:270671	117/415 (28%)
		TyrKc	838..1106	CDD:197581	113/394 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900