DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and TIE1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens

Alignment Length:	983	Identity:	231/983 - (23%)
Similarity:	369/983 - (37%)	Gaps:	279/983 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PSGHYNVQ--------EYANRTIQMTANFE----------GFPTP---SFSWFKPDGTEVRQSEN 488
            |||.:.|.        :..|...::..|.|          |.|.|   |....|||||.:..::
Human   336 PSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTK- 399

  Fly   489 NFKILSTELSTM-LQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV------MDAPAL--KMSDA 544
              .|:..|.:|. .:|....|.|||.:..|.|.|.|...|.:.|:|      :.||.|  |.|..
Human   400 --AIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQ 462

  Fly   545 YVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSV-LNQNFSLPSEQEKYQFQTR---PR 605
            .|    |:.|.......|.:.|...:||......|.|..| .::|.:|.:.:.|..:..|   .|
Human   463 LV----VSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSR 523

  Fly   606 PGKLSVERIYEVSFLPT----EPGILTCIAQNIIDGKERRTLTKAHVLLGN--ISENMTIYGFDK 664
            ||: ..|..:....|.|    ||.:...:....::|.:|..::.:..|:..  :.:...:..:|.
Human   524 PGE-GGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG 587

  Fly   665 DHKIAKEDNV-----------------NFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTK 712
            .....:.:||                 ::..:...||..      :.|   ..|...|:....:.
Human   588 TRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCT------LLG---PASPPAHVLLPPSG 643

  Fly   713 YSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSA------------------ 759
            ......:|...:||                     .||.|....|.|
Human   644 PPAPRHLHAQALSD---------------------SEIQLTWKHPEALPGPISKYVVEVQVAGGA 687

  Fly   760 --PQWTNGGQ-EGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLI 821
              |.|.:..: |..|.|.|.|:.:........|....:..|   ...|.||.|.:.::.|.
Human   688 GDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDW---SNTVEESTLGNGLQAEG---- 745

  Fly   822 THLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKE 886
                |..|   ....|..||:     .::::.:..:|       .....||..|...:.:|....
Human   746 ----PVQE---SRAAEEGLDQ-----QLILAVVGSVS-------ATCLTILAALLTLVCIRRSCL 791

  Fly   887 HKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFP---RENLKLGKQLGAGAFGV 948
            |:|......:|  :.||..:...:..|||..:.:|.|  ....:|   .|::.....:|.|.||.
Human   792 HRRRTFTYQSG--SGEETILQFSSGTLTLTRRPKLQP--EPLSYPVLEWEDITFEDLIGEGNFGQ 852

  Fly   949 VLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKR 1013
            |::..   |:::......|:||:|..|.....|....||:::..||.|.|::||||| .||  :.
Human   853 VIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA-CKN--RG 911

  Fly  1014 ELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANV 1078
            .|.:.:||..:||:.:||.::|
Human   912 YLYIAIEYAPYGNLLDFLRKSR------------------------------------------- 933

  Fly  1079 GFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDD 1143
                                                                        |.|.|
Human   934 ------------------------------------------------------------VLETD 938

  Fly  1144 QIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCED 1208
                     ||:...:.|    |.|:::..|:.:|...|.||.|||.|:.:|.||||||:|:.|:
Human   939 ---------PAFAREHGT----ASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGEN 990

  Fly  1209 NVVKICDFGLARSMYRGDN-YKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAK 1272
            ...||.||||:    ||:. |.|...|:||::|:|:|||:..|::|.|||||:|::|||:.||..
Human   991 LASKIADFGLS----RGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGG 1051

  Fly  1273 VPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV 1337
            .||.|: ...||:.||..|||||:|:..:.|:||:|.:|||..|..||.||::..:...||  :.
Human  1052 TPYCGM-TCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML--EA 1113

  Fly  1338 ASHYLDLN 1345
            ...|::::
Human  1114 RKAYVNMS 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	24/80 (30%)
		IG_like	672..754	CDD:214653	13/98 (13%)
		Ig	674..739	CDD:143165	9/81 (11%)
		IGc2	779..840	CDD:197706	10/60 (17%)
		PKc_like	927..1332	CDD:304357	117/408 (29%)
		Pkinase_Tyr	935..1329	CDD:285015	115/394 (29%)
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248	4/7 (57%)
		ig	356..441	CDD:278476	24/87 (28%)
		fn3	452..536	CDD:278470	23/88 (26%)
		fn3	548..632	CDD:278470	9/92 (10%)
		FN3	644..736	CDD:238020	19/115 (17%)
		PTKc_Tie1	836..1132	CDD:270671	119/415 (29%)
		TyrKc	839..1107	CDD:197581	115/394 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810