Protein Alignment Pvr and TEK

DIOPT Version :9

• Sequence 1: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Sequence 2: NP_000450.3
• Gene: TEK / 7010
• HGNCID: 11724
• Length: 1124
• Species: Homo sapiens
• Alignment Length: 992
• Identity: 232/992 - (23%)
• Similarity: 375/992 - (37%)
• Gaps: 313/992 - (31%)

  Fly   421 QNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPS---FSWFKPDGTE 482
            :.:||.|.:|..|   ..::.|.  ||.:|          ......|:|.|:   .:..|||||.
Human   343 EGIQRMTPKIVDL---PDHIEVN--SGKFN----------PICKASGWPLPTNEEMTLVKPDGTV 392

  Fly   483 VRQSE-NNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYV 546
            :...: |:....|..:.|:.::|.   .|||.:|...:...|:|::.:|:||...|....:...:
Human   393 LHPKDFNHTDHFSVAIFTIHRILP---PDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVI 454

  Fly   547 QVG-SVARLECTVRSY----PPAIVTFFFRPCSLEPQWPTCSVLNQ----NFSLPSEQEKYQFQT 602
            ..| :.|.:..:...|    |.......::|.:....|....|.|:    |:..|..:.:...|.
Human   455 DTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQL 519

  Fly   603 RPR-------PGKLSVERIYEVSF-LPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTI 659
            ..|       ||  .|.|....|. ||...|:      |::. |.:.||
Human   520 VRRGEGGEGHPG--PVRRFTTASIGLPPPRGL------NLLP-KSQTTL---------------- 559

  Fly   660 YGFDKDHKIAKEDNVNFTCEALAYHFDGNLKW---FINGED----------LKESDSVHIETSHT 711
                                        ||.|   |.:.||          :::||..:|:..
Human   560 ----------------------------NLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVP-- 594

  Fly   712 KYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLY-VHDPSAPQWTNGGQEGHSKIKR 775
              ...::|.:..:..|::  |..||..|.|.....|.::..: :.|...||..|
Human   595 --GNLTSVLLNNLHPREQ--YVVRARVNTKAQGEWSEDLTAWTLSDILPPQPEN----------- 644

  Fly   776 KLSQTLELECASTAVPVAIVRW-FKDDKEVTESKLR----------HIIEKESKLLITH-----L 824
                   ::.::.....|::.| ..|...::...:|          |:..|.....||.     |
Human   645 -------IKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGL 702

  Fly   825 YPGDEGVYKCVV--ENRLDRIERSFTVVISDLP-GISMAWVWFGVILFLILIG---------LCV 877
            .|  |..|:..:  ||.:.....:|:..:..|| ..:.|.:..|.:|.:.::|         |..
Human   703 EP--ETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLA 765

  Fly   878 FLAVRYQKEH--KRHLA-----LKAAGLANFEEGAVG-----HINPDLTLDEQAELLPYNREFEF 930
            ||.:...|..  :|.:|     ::......|..|.:.     ..|||.|:   ..:|.:|
Human   766 FLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTI---YPVLDWN----- 822

  Fly   931 PRENLKLGKQLGAGAFGVVLKGEAK--GIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHL 993
               ::|....:|.|.||.|||...|  |:|.:     .|:|.:|..|..:..|....||:::..|
Human   823 ---DIKFQDVIGEGNFGQVLKARIKKDGLRMD-----AAIKRMKEYASKDDHRDFAGELEVLCKL 879

  Fly   994 GQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRM 1058
            |.|.|::|||||...   :..|.:.:||...||:.:||.::|
Human   880 GHHPNIINLLGACEH---RGYLYLAIEYAPHGNLLDFLRKSR----------------------- 918

  Fly  1059 SDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATY 1123
                                                                             
Human   919 ----------------------------------------------------------------- 918

  Fly  1124 SYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYL 1188
                       |:.|.|.                 :...::.|.|:::..|:.:|..||||||||
Human   919 -----------VLETDPA-----------------FAIANSTASTLSSQQLLHFAADVARGMDYL 955

  Fly  1189 SSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFST 1253
            |.|:.:|.||||||||:.|:.|.||.||||:|..   :.|.|...|:||::|:|:|||:..|::|
Human   956 SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1017

  Fly  1254 YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPES 1318
            .|||||||::|||:.||...||.|: ...||:.||..|||:|||...:.|:|::|.:|||:.|..
Human  1018 NSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYE 1081

  Fly  1319 RPLFAELEKRFANMLGE 1335
            ||.||::......||.|
Human  1082 RPSFAQILVSLNRMLEE 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	4/10 (40%)
		Ig	<363..432	CDD:299845	4/10 (40%)
		Ig	466..533	CDD:299845	19/70 (27%)
		IG_like	672..754	CDD:214653	17/95 (18%)
		Ig	674..739	CDD:143165	14/77 (18%)
		IGc2	779..840	CDD:197706	14/78 (18%)
		PKc_like	927..1332	CDD:304357	118/406 (29%)
		Pkinase_Tyr	935..1329	CDD:285015	118/395 (30%)
TEK	NP_000450.3	Ig_Tie2_1	24..118	CDD:402176
		EGF_Lam	230..275	CDD:238012
		EGF_Lam	314..>342	CDD:238012
		IgI_Tie2	348..439	CDD:409556	25/108 (23%)
		Ig strand B	366..370	CDD:409556	1/13 (8%)
		Ig strand C	382..386	CDD:409556	0/3 (0%)
		Ig strand E	407..411	CDD:409556	0/3 (0%)
		Ig strand F	421..426	CDD:409556	1/4 (25%)
		Ig strand G	434..437	CDD:409556	0/2 (0%)
		fn3	445..520	CDD:394996	12/74 (16%)
		fn3	544..626	CDD:394996	22/138 (16%)
		FN3	639..731	CDD:238020	18/111 (16%)
		PTKc_Tie2	816..1118	CDD:133219	123/419 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810