DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Pdgfrl

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_081116.3	Gene:	Pdgfrl / 68797	MGIID:	1916047	Length:	375	Species:	Mus musculus

Alignment Length:	480	Identity:	86/480 - (17%)
Similarity:	151/480 - (31%)	Gaps:	178/480 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCE--- 69
            :||.|||:                  .:::|:.||::......|.:........|:...|.:
Mouse     5 LLLGLLLL------------------HEALEDVGGQHSPKNKRPKEQGENRIKPTNKKAKPKIPK 51

  Fly    70 -DDEPMSWWTSQSQYVHVKSFDN--TEDPARPF----GTSLHL----IEVTADYVAAYYCVKTSK 123
             .|...:..|::||.:.:::..|  .:.||...    |.:|.|    .:|...| .||  :.|.|
Mouse    52 VKDRDSTDSTAKSQSIMMQAMGNGRFQRPAATVSLLAGQTLELRCKGSKVEWSY-PAY--LDTFK 113

  Fly   124 FSQIAKEEQSDEAMIELVN----------------QGY--------ASSIYVYVNDPDTKLVDS- 163
            .|::..::......:.|||                .||        ..|.|::..:.....|.|
Mouse   114 DSRLTVKQSERYGQLTLVNSTAADTGEFSCWEQLCNGYICRRDEAKTGSTYIFFTEKGELFVPSP 178

  Fly   164 --HNVVTARQYTDVVIPCKPAMPDTEVLL--ETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGD 224
              .:||........|:||:...|..:|.|  |....|:.::.:...||.:|||.
Mouse   179 SYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPANGTDIVYDMKRGFV----------- 232

  Fly   225 YYCRPNPPFPHNEEE-----------MTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVL 278
             |.:     ||::.:           .:.|.|::....:::|         :..|..|     :|
Mouse   233 -YLQ-----PHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVP---------SGPPSTT-----IL 277

  Fly   279 TVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFT 343
            ..:|:       :||||
Mouse   278 ASSNK-------VRGGD------------------------------------------------ 287

  Fly   344 DTNFTLDC----EQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQT--GRSTLTVLN 402
              :.::.|    |....||    ..|..|.:.:.|....|.......|...|.|  .:|.:.|.:
Mouse   288 --DISVLCTVLGEPDVEVE----FRWLFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVIIVED 346

  Fly   403 AQPSDTGLYKCVTTDNSNQNVQRAT 427
            .:..|.|.|.|..     ||::..|
Mouse   347 FETIDAGYYICTA-----QNLRGQT 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	20/88 (23%)
		Ig	<363..432	CDD:299845	16/67 (24%)
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
Pdgfrl	NP_081116.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..63		7/42 (17%)
		Ig	80..143	CDD:299845	15/65 (23%)
		IG_like	83..>143	CDD:214653	13/62 (21%)
		I-set	272..373	CDD:254352	28/166 (17%)
		Ig	293..372	CDD:299845	20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900