DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and csf1ra

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_571747.1 Gene:csf1ra / 64274 ZFINID:ZDB-GENE-001205-1 Length:977 Species:Danio rerio


Alignment Length:1313 Identity:294/1313 - (22%)
Similarity:469/1313 - (35%) Gaps:462/1313 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 IILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVK 120
            :||::.:...|.||.|.|:::....::  |.:.........|.|    .:.:.|.|:...|.||.
Zfish    36 VILESGSPLQLVCEGDGPVTFLPRLAK--HKRYISKEVGKIRSF----RVEKTTVDFTGTYKCVY 94

  Fly   121 TSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVND-------PDTKLVDSHNVVTARQYTDVVIP 178
            .:         .:|..:        :||::|:|.|       |.|.|     ....::..|:::|
Zfish    95 MN---------GNDSNL--------SSSVHVFVRDSRVLFVSPSTSL-----RYVRKEGEDLLLP 137

  Fly   179 CKPAMPD-TEVLLETSNGEMHSSKSVG---RYDPQRGFTIEIRSIVDG--GDYYCRPNPPFPHNE 237
            |....|: |:......||   |:...|   .|||::|  :.||::..|  .||.|..........
Zfish   138 CLLTDPEATDFTFRMDNG---SAAPYGMNITYDPRKG--VLIRNVHPGFNADYICCARIGGAEKV 197

  Fly   238 EEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRER 302
            .::.||.:        |.|.:....||                         |.|.....|..||
Zfish   198 SKIFSINI--------IQRLRFPPYVY-------------------------LKRNEYVKLVGER 229

  Fly   303 ARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFT 367
            .:.|.....|                                 ||            .|.:.|  
Zfish   230 LQISCTTNNP---------------------------------NF------------YYNVTW-- 247

  Fly   368 PSRDENRIFASQSRTDPKTRNSTHQTG-----RSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRAT 427
                     ...||..||....:...|     .|.||:.:.|.|.||...|  |..:......:|
Zfish   248 ---------THSSRMLPKAEEKSTMEGDRLAIESILTIPSVQLSHTGNITC--TGQNEAGANSST 301

  Fly   428 YRIKVLKQNESYLNVGEPSGH------YNVQEYANRTIQMTANFEGF-PTPSFSWFKPDGTEVRQ 485
            .::.|::  |.|:.:......      .:::......:.:....|.: |..|..|..|.......
Zfish   302 TQLLVVE--EPYIRLSPKLSSKLTHRGLSIEVSEGDDVDLGVLIEAYPPLTSHKWETPTSHNASL 364

  Fly   486 SENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGS 550
            .||.|...:.....:|.:.....::.|.|.|...||.......:::.:...|.     |.|:..:
Zfish   365 PENRFFNHNDRYEALLLLKRLNFEEIGQYTLNVKNSMKSASITFDIKMYTKPV-----ARVKWEN 424

  Fly   551 VARLECTVRSYP-PAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERI 614
            |..|.|....|| |:|:            |..|:                               
Zfish   425 VTTLSCRSYGYPAPSIL------------WYQCT------------------------------- 446

  Fly   615 YEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCE 679
                      ||.|...:|..|.:..:|.|                             |.|..|
Zfish   447 ----------GIRTTCPENTTDLQPIQTQT-----------------------------VEFQKE 472

  Fly   680 ALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAV 744
            :..                    :|.:|:            :.|:....|.|..|.|::      
Zfish   473 SFG--------------------AVGVES------------VLTVGPNRRMTVVCVAFN------ 499

  Fly   745 YSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKL 809
                                        :..:.|.|..:|.:                       
Zfish   500 ----------------------------LVGQGSDTFSMEVS----------------------- 513

  Fly   810 RHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIG 874
                                           |:|   ||   |.:.|.::|.|..|::|      
Zfish   514 -------------------------------DQI---FT---SAMCGSTVAMVVLGLLL------ 535

  Fly   875 LCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGK 939
              :|:..:|:::.:..:..|.....|         ..:.|..:..: ||||.::||||:.|||||
Zfish   536 --IFMIYKYKQKPRYEIRWKIIEATN---------GNNYTFIDPTQ-LPYNEKWEFPRDKLKLGK 588

  Fly   940 QLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLG 1004
            .|||||||.|::..|.|:.:|:..|.|||||:||:|..:...||:|||||:.|||||.|:|||||
Zfish   589 TLGAGAFGKVVEATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLG 653

  Fly  1005 AVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQI-------NPDTDHIDPSIMTQRMSDNY 1062
            |.|..   ..::||.|||..|::.|||....:.|:|.:       .|.||:  .::.|:||    
Zfish   654 ACTHG---GPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDY--KNVSTERM---- 709

  Fly  1063 ELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDR 1127
                                  ::                            |:.||.::...|.
Zfish   710 ----------------------FV----------------------------RSDSGISSTCSDH 724

  Fly  1128 QMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKK 1192
            .:|  ...:|:.|.:..:.|::..|           .::..:...||:.::.|||:|:|:|::|.
Zfish   725 YLD--MRPVTSRPTNSALDSSSECQ-----------EDSWPLDMDDLLRFSSQVAQGLDFLAAKN 776

  Fly  1193 VLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDV 1257
            .:|.|:||||:||....|.|||||||||.:....||....|.:||:||:|.||:.:.|::..|||
Zfish   777 CIHRDVAARNVLLTNSRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDV 841

  Fly  1258 WSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF 1322
            |||||:|||:|||.|.|||.|..:.:.:..:..||:|.:|.||..|:|.||..||..:...||.|
Zfish   842 WSYGIMLWEIFSLGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTF 906

  Fly  1323 AELEKRFANMLGE 1335
            :::.:....||||
Zfish   907 SKISQMIQRMLGE 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 19/90 (21%)
Ig strand C 363..366 CDD:409353 0/2 (0%)
Ig strand E 396..400 CDD:409353 2/3 (67%)
Ig strand F 410..415 CDD:409353 1/4 (25%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 14/75 (19%)
Ig strand B 459..463 CDD:409353 0/3 (0%)
Ig strand C 472..476 CDD:409353 1/3 (33%)
Ig strand E 497..503 CDD:409353 1/5 (20%)
Ig strand F 513..518 CDD:409353 2/4 (50%)
Ig 671..>742 CDD:472250 10/70 (14%)
Ig strand B 674..678 CDD:409353 2/3 (67%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 0/3 (0%)
Ig strand F 731..736 CDD:409353 2/4 (50%)
Ig 779..851 CDD:472250 6/71 (8%)
Ig strand B 781..785 CDD:409570 0/3 (0%)
Ig strand C 794..798 CDD:409570 0/3 (0%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 0/4 (0%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 147/411 (36%)
csf1raNP_571747.1 Ig_2 41..110 CDD:464026 17/91 (19%)
IG_like 126..200 CDD:214653 19/78 (24%)
Ig 226..306 CDD:472250 23/137 (17%)
Ig strand B 230..234 CDD:409551 0/3 (0%)
Ig strand C 244..248 CDD:409551 1/14 (7%)
Ig strand E 272..276 CDD:409551 2/3 (67%)
Ig strand F 286..291 CDD:409551 1/6 (17%)
Ig strand G 299..302 CDD:409551 0/2 (0%)
Ig 311..410 CDD:472250 15/98 (15%)
Ig strand B 337..341 CDD:409364 0/3 (0%)
Ig strand C 351..354 CDD:409364 1/2 (50%)
Ig strand E 378..382 CDD:409364 1/3 (33%)
Ig strand F 392..397 CDD:409364 2/4 (50%)
Ig strand G 405..408 CDD:409364 0/2 (0%)
Regulatory juxtamembrane domain. /evidence=ECO:0000250 544..576 7/41 (17%)
PTKc_CSF-1R 545..918 CDD:133237 155/454 (34%)
Activation loop. /evidence=ECO:0000250 799..821 9/21 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..977 1/1 (100%)

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