DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and RET

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens


Alignment Length:1103 Identity:261/1103 - (23%)
Similarity:432/1103 - (39%) Gaps:339/1103 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   434 KQNESYLNVGEPSGHYNV-QEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTEL 497
            :|.|.|..|...:.|... :|.......:|...|....|:|    |.|.:...:...||.....:
Human   232 EQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTF----PAGVDTASAVVEFKRKEDTV 292

  Fly   498 STMLQVLNAQ-LQDSGTYVLRGSNSF--GVVQREYNVSVMDAPALKMSDAYVQV-GSVARLECTV 558
            ...|:|.:|. :..||..|.|.:::.  |....:....|...|    ::..||. ||..|  .||
Human   293 VATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWP----NETSVQANGSFVR--ATV 351

  Fly   559 RSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQ---------FQTRPRPGKLSVERI 614
            ..|.                    .|||:|.|: ||....|         || .|..|.|.:.  
Human   352 HDYR--------------------LVLNRNLSI-SENRTMQLAVLVNDSDFQ-GPGAGVLLLH-- 392

  Fly   615 YEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCE 679
            :.||.||....:.:..:.: :..:.||                    |.:..|:..|:     |:
Human   393 FNVSVLPVSLHLPSTYSLS-VSRRARR--------------------FAQIGKVCVEN-----CQ 431

  Fly   680 ALAYHFDG-NLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDA 743
            |    |.| |:::.:                |:..:..||:.:.|.::...|.    .:.||..|
Human   432 A----FSGINVQYKL----------------HSSGANCSTLGVVTSAEDTSGI----LFVNDTKA 472

  Fly   744 VYSSREIDLYVHDPSAPQWTNGGQEGHSKI--------------------KRKLSQTLELECAST 788
            :...:..:|:....:..|.|:...:....:                    ||:|...   ||...
Human   473 LRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECE---ECGGL 534

  Fly   789 AVPVAIVRWFKDDK----------------------EVTESKLRHIIEKE---SKLLITH----- 823
            ..|.....|.:.|.                      :|.|::..:|..::   ..::..|     
Human   535 GSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEP 599

  Fly   824 -----------LYPGDEGVYKCVVENRLDRI--ERSFTVVISDLPGISMAWVWFGVILFLILIGL 875
                       .:|.:|..: |..|:..|.:  |...||:        .|.|.|..|:.::|...
Human   600 RGIKAGYGTCNCFPEEEKCF-CEPEDIQDPLCDELCRTVI--------AAAVLFSFIVSVLLSAF 655

  Fly   876 CVFLAVRYQK-EHKRHLA------LKAAGLANFEEGAVGHINPDL-TLDEQAELLPY----NREF 928
            |:..   |.| .||..::      .:.|........:.|...|.| :::.|..:..:    :.::
Human   656 CIHC---YHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW 717

  Fly   929 EFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHL 993
            ||||:||.|||.||.|.||.|:|..|..::.....|||||||:|..|....:|.|:||..::..:
Human   718 EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV 782

  Fly   994 GQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRM 1058
             .|.:|:.|.||.:::   ..|::||||.::|:::.||..:||     :.|              
Human   783 -NHPHVIKLYGACSQD---GPLLLIVEYAKYGSLRGFLRESRK-----VGP-------------- 824

  Fly  1059 SDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATY 1123
                                                                   |..|||.:  
Human   825 -------------------------------------------------------GYLGSGGS-- 832

  Fly  1124 SYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYL 1188
                                            |::...|..:...:|..||||:|:|:::||.||
Human   833 --------------------------------RNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865

  Fly  1189 SSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFST 1253
            :..|::|.||||||||:.|...:||.||||:|.:|..|:|.|...|::|:||:|:|||.||:::|
Human   866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930

  Fly  1254 YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPES 1318
            .|||||:|::|||:.:|...|||||.| :.|||.|..|:|||:|...::|:|.:||:||::.|:.
Human   931 QSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDK 994

  Fly  1319 RPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEY---MKKQSTDYLALMGSPDELAPAAPRY 1380
            ||:||::.|....|:.:  ...||||.......::.|   :.::.|..:....:|      .|| 
Human   995 RPVFADISKDLEKMMVK--RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP------LPR- 1050

  Fly  1381 VNGHIVPDIRIEELPDDYME-----MSRDSDPDACTAIFSP---TRLEGESSDFPDFSSETTF 1435
                        .||..::|     ||..:.|..     ||   ||.:|.::.||.:.:::.:
Human  1051 ------------ALPSTWIENKLYGMSDPNWPGE-----SPVPLTRADGTNTGFPRYPNDSVY 1096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652
Ig <363..432 CDD:299845
Ig 466..533 CDD:299845 15/69 (22%)
IG_like 672..754 CDD:214653 14/82 (17%)
Ig 674..739 CDD:143165 10/65 (15%)
IGc2 779..840 CDD:197706 13/101 (13%)
PKc_like 927..1332 CDD:304357 133/404 (33%)
Pkinase_Tyr 935..1329 CDD:285015 128/393 (33%)
RETNP_066124.1 Cadherin 172..261 CDD:278457 6/28 (21%)
PTKc_RET 723..1012 CDD:173631 130/403 (32%)
Pkinase_Tyr 724..1005 CDD:285015 128/393 (33%)
Inhibitors binding 805..807 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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