DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and fgfr3

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio

Alignment Length:	924	Identity:	250/924 - (27%)
Similarity:	358/924 - (38%)	Gaps:	328/924 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 AHVLLGN----ISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHI 706
            ||:|...    :|..:.:  |.:|:.....|.|..:|....:...  :.|      .|:.|:|.
Zfish    40 AHLLSPEPTDWVSSEVEV--FLEDYVAGVGDTVVLSCTPQDFLLP--IVW------QKDGDAVS- 93

  Fly   707 ETSHTKYSYKSTVHITTISDRDRGTYECRAYH-------------------NDKDAVYSSREIDL 752
            .::.|:...|: :.|..:|..|.|.|.||..|                   :|:|  |...|.:.
Zfish    94 SSNRTRVGQKA-LRIINVSYEDSGVYSCRHAHKSMLLSNYTVKVIDSLSSGDDED--YDEDEDEA 155

  Fly   753 YVHDPSAPQWTNGGQEGHSKIKRKL-----SQTLELECASTAVPVAIVRWFKDDKEVTES----- 807
            ...:..||.||..     .::::||     :.|::..|.:...|...:.|.|:.||....
Zfish   156 GNGNAEAPYWTRS-----DRMEKKLLAVPAANTVKFRCPAAGNPTPSIHWLKNGKEFKGEQRMGG 215

  Fly   808 -KLRHIIEKESKLLITHLYPGDEGVYKCVVENR---------LDRIERS-------------FTV 849
             |||   :::..|::....|.|.|.|.|||:|:         ||.:|||             .||
Zfish   216 IKLR---DQQWSLVMESAVPSDRGNYTCVVQNKYGTIKHTYQLDVLERSPHRPILQAGLPANQTV 277

  Fly   850 VI-----------SD-------------------------------------------------- 853
            |:           ||
Zfish   278 VVGSDVEFHCKVYSDAQPHIQWLKHIEVNGSQYGPNGAPYVNVLKTAGINTTDKELEILYLTNVS 342

  Fly   854 ---------LPGISMAW----VWFGV-------------------------ILFLILIGLC---- 876
                     |.|.|:.:    .|..|                         ||.:::|.||
Zfish   343 FEDAGQYTCLAGNSIGYNHHSAWLTVLPAVEMEREDDYADILIYVTSCVLFILTMVIIILCRMWI 407

  Fly   877 ----VFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLT------------LDEQAEL-LPY 924
                ...|...||..|  ..||.....:.|..:..:.|..|.            |...:|| ||.
Zfish   408 NTQKTLPAPPVQKLSK--FPLKRQVTVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPS 470

  Fly   925 NREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPT--TTVAVKMVKATADNEVVRALVSEL 987
            :.::||.|..|.|||.||.|.||.|:..||.||.:|:|.  .||||||:|....::.:..||||:
Zfish   471 DPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEM 535

  Fly   988 KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPS 1052
            ::|..:|:|.|::|||||.|::   ..|.|:|||...||::.:|...|
Zfish   536 EMMKMIGKHKNIINLLGACTQD---GPLYVLVEYASKGNLREYLRARR----------------- 580

  Fly  1053 IMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTG 1117
                                                       ||
Zfish   581 -------------------------------------------PP-------------------- 582

  Fly  1118 SGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVA 1182
                  ..|...|||     .:|.:                         |:|..||:|.|:|||
Zfish   583 ------GMDYSFDTC-----KIPNE-------------------------TLTFKDLVSCAYQVA 611

  Fly  1183 RGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLS 1247
            |||:||:|||.:|.||||||:|:.||||:||.||||||.::..|.|||:.||:||:||:|.|:|.
Zfish   612 RGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALF 676

  Fly  1248 DHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECW 1312
            |.|::..|||||||::|||:|:|...||||| |.:|||..|.:|:||:||.....|||.||.|||
Zfish   677 DRVYTHQSDVWSYGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHELYMIMRECW 740

  Fly  1313 RKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQST----DYLALMGSPDEL 1373
            ...|..||.|.:|.:....:|.......||||:.|:.|.:.......||    |.......|...
Zfish   741 HAVPSQRPTFRQLVEDHDRVLSMTSTDEYLDLSVPFEQYSPTCPDSNSTCSSGDDSVFAHDPLPE 805

  Fly  1374 APAAPR--YVNGHI 1385
            .|..|:  :.||.|
Zfish   806 EPCLPKHHHSNGVI 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	21/100 (21%)
		Ig	674..739	CDD:143165	16/83 (19%)
		IGc2	779..840	CDD:197706	19/75 (25%)
		PKc_like	927..1332	CDD:304357	148/406 (36%)
		Pkinase_Tyr	935..1329	CDD:285015	145/395 (37%)
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706	14/63 (22%)
		Ig2_FGFR	173..257	CDD:143265	22/86 (26%)
		Ig3_FGFR-2	280..369	CDD:143266	6/88 (7%)
		PTKc_FGFR3	468..801	CDD:173652	160/452 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810