DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and kdr

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001019824.2	Gene:	kdr / 554230	ZFINID:	ZDB-GENE-041001-112	Length:	1357	Species:	Danio rerio

Alignment Length:	1617	Identity:	394/1617 - (24%)
Similarity:	653/1617 - (40%)	Gaps:	418/1617 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDD 71
            |:||.:||...:  :.|:.| :|.|||             |.:...:..|.::|..:..:.|...
Zfish     8 LLLLDILLTFNV--AKAIEL-RFVPDP-------------PTLNITEKTIKINASDTLQITCRGR 56

  Fly    72 EPMSWWTSQ---SQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQS 133
            :.:.|.|..   |....:...|.:.|..  |.::|.|.:..|:....|.|.    :....||:
Zfish    57 QILEWSTPHNRTSSETRLTISDCSGDGL--FCSTLTLSKAVANETGEYRCF----YKSPPKED-- 113

  Fly   134 DEAMIELVNQGYAS-SIYVYVND---PDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSN 194
                      |..| ::||::.|   |..::...::||..|:...|||||..::.|..|.|.|..
Zfish   114 ----------GKTSVAVYVFIQDYRTPFVRIAQDYDVVFIREGEQVVIPCLVSVEDLNVTLYTKY 168

  Fly   195 --GEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRT 257
              .|:.:......:|.:|||.:..|.:...|..||
Zfish   169 PVKELSTDGKEVIWDSRRGFILPSRVVSYAGVVYC------------------------------ 203

  Fly   258 QTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRG---GDGTLSRERARRSPARLAPMNASPSP 319
            |||                :...|.||:..:..:.|   .|.|||.:..|.:......:|.:
Zfish   204 QTT----------------IRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCT--- 249

  Fly   320 RPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDP 384
                                 ..|:.|..:|            .:|..| .::..:..|.|.:..
Zfish   250 ---------------------AHTERNVGID------------FQWTFP-HEKRSVNGSMSTSRY 280

  Fly   385 KTRNSTHQTGRS-----TLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGE 444
            ||.::..:...|     ||||.|...:|||.|.|..:....|.:.:|:    ::...:.::.:.:
Zfish   281 KTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQAS----LIVYEKPFIALSD 341

  Fly   445 PSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQ 509
            ........:..:...::...:..:|.|:..|:|.|...|.:.....|...   ...|.:.....:
Zfish   342 QLWQTVEAKAGDAEAKILVKYYAYPEPAVRWYKNDQLIVLRDGYRMKFYR---GVHLTIYGVTEK 403

  Fly   510 DSGTYVLRGSNSFGVVQ--REYNVSVMDAPALKMSDAYV-----QVGSVARLECTVRSYPPAIVT 567
            |:|.|.:..:|.....:  |.:.:.|.|.|.:...|..:     ..||...|.||.....
Zfish   404 DAGNYTVVMTNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGS----- 463

  Fly   568 FFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQ 632
               .|.:::.||           :|.|....:|..:..|.....::..|:|   ...|....|:|
Zfish   464 ---SPVTIKWQW-----------MPREDCPVRFLPKSDPSMAKCDKWREMS---NNTGKNPLISQ 511

  Fly   633 NIIDGKERRTLT-----KA--HVLLGNISENMTIYGFDKDHKI-------------------AKE 671
            ..:|.:..:|::     ||  |.|...|:.|.    ..:|.::                   .:.
Zfish   512 TSVDERTLKTISTLKIQKAVDHALYRCIATNK----MGQDQRVIVFQVTRFLNLSVLPSSSPIEG 572

  Fly   672 DNVNFTCEA--LAYHFDGNLKWF----INGEDLKESDSVHIETSHTKYSYKSTVHITTISD---- 726
            .:|...|.|  |.|:   ||:|:    :...|...: :|..:|....:.::..|.::.:..
Zfish   573 QDVIMRCVADRLLYY---NLRWYRVANVANHDPPPA-AVPCDTLTLSHLHQPNVTVSGLQGTNVT 633

  Fly   727 ----------RDRGTYECRAY---HNDKDAVYSS---REIDLYVHDPSAPQWTNGGQEGHSKIKR 775
                      .|:|.|.|:..   .|:|..:..:   |.:::                  |:|..
Zfish   634 LDMPIPNATMMDQGLYACQVEIVGTNEKTCLLHNLRLRALEM------------------SRIVT 680

  Fly   776 KL-------SQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESK--LLITHLYPGDEGV 831
            .|       |.:..|.|..:..|...:.|.||::.|.|..  .:|.|.|.  |.|..:...|.|:
Zfish   681 NLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGS--GVILKRSNRVLTIQRVKKEDSGL 743

  Fly   832 YKCVVENR-----------LDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQK 885
            |.|...|:           :|..|....|.:. :|        .|.::..:.:.|.:...:|.:|
Zfish   744 YICTACNQQGCESSEARISVDGAEEKMNVELI-MP--------IGAVVIAMFLWLLIVFVIRNRK 799

  Fly   886 EHKRHLALKAAGLANFEEGAVGHI-----NPDLTLDEQAELLPYN-REFEFPRENLKLGKQLGAG 944
            .            .|..:...|::     :.|:.:||..|.|.|: .::||||:.||||:.||.|
Zfish   800 R------------PNDGDLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRG 852

  Fly   945 AFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKN 1009
            |||.|::..|.||.:....|||||||:|..|.:...|||:|||||::|:|.||||||||||.||.
Zfish   853 AFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQ 917

  Fly  1010 IAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLK 1074
              ...||||||||:.||:.::|...|.                                     :
Zfish   918 --GGPLMVIVEYCKHGNLSSYLKSKRG-------------------------------------E 943

  Fly  1075 YANVGFPIHSYINEPHNNNTQPPTHRR--NSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMT 1137
            |:            |:...|....:||  ..|.|||.|.    .|.||:|     ::|.|.....
Zfish   944 YS------------PYKKRTPRMPNRREVQQDEDPREGD----LGLGTST-----RLDICTGTAV 987

  Fly  1138 TVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARN 1202
            .....:|  ::.::|.      :.:|::...:|..||||::||||:||::|:|:|.:|.||||||
Zfish   988 CTRTGEQ--TSTTLQD------EQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARN 1044

  Fly  1203 ILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEM 1267
            |||.|::|||||||||||.:|:..:|.:..:.:||:||:|.|::.|.|::|.|||||:|::|||:
Zfish  1045 ILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEI 1109

  Fly  1268 FSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANM 1332
            |||...||||:..::....:|.:|.||..|.:|..|:|:.||:||...|..||.|.:|.:...|:
Zfish  1110 FSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNL 1174

  Fly  1333 L-------GEDVASHYLDLNNPYMQS-----NIEYMKKQS-----TDYLALMGSPDELAPAAPRY 1380
            |       |:|    |:.|.|..|:.     ::....|:|     |:.....|:...|  ..|:.
Zfish  1175 LQASAQQDGKD----YIPLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYGNAPPL--GFPQQ 1233

  Fly  1381 VNGHIVP-------DIRIEE--LPDDYME----MSRDS----DPDACTAI-FSP-TRLEGESSDF 1426
            :|...||       ||.:|.  :.|.:::    :||:.    |..|...: ||| .|.:.:.|..
Zfish  1234 INSSGVPVNMTGFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESLA 1298

  Fly  1427 PDFSSETTFNFPGAR----QSPTLSNN---LNSGSSK--PLRKKNGMPTVDVADQAP 1474
            .:.|::|:....|..    ::|..:|.   |.....|  ||.|:|...:.:|...||
Zfish  1299 SESSNQTSGYQSGYHSDDAEAPIYANEEMILKRDIRKKPPLPKRNDKFSAEVRYSAP 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	21/90 (23%)
		Ig	<363..432	CDD:299845	19/73 (26%)
		Ig	466..533	CDD:299845	13/68 (19%)
		IG_like	672..754	CDD:214653	19/107 (18%)
		Ig	674..739	CDD:143165	16/87 (18%)
		IGc2	779..840	CDD:197706	18/73 (25%)
		PKc_like	927..1332	CDD:304357	160/406 (39%)
		Pkinase_Tyr	935..1329	CDD:285015	156/395 (39%)
kdr	NP_001019824.2	Ig_2	143..221	CDD:290606	25/123 (20%)
		IG_like	233..331	CDD:214653	24/138 (17%)
		Ig	241..335	CDD:299845	23/134 (17%)
		IG_like	345..429	CDD:214653	13/86 (15%)
		Ig2_VEGFR-2	356..429	CDD:143272	13/75 (17%)
		IG	571..654	CDD:214652	16/86 (19%)
		Ig	571..654	CDD:299845	16/86 (19%)
		I-set	677..763	CDD:254352	21/87 (24%)
		IGc2	691..753	CDD:197706	18/63 (29%)
		PKc_like	835..1178	CDD:304357	162/410 (40%)
		Pkinase_Tyr	843..1171	CDD:285015	156/395 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..975		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1357		15/60 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1456
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1729
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	1	1.000	-	-		otm25366
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830