DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and STYK1

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_060893.2 Gene:STYK1 / 55359 HGNCID:18889 Length:422 Species:Homo sapiens


Alignment Length:593 Identity:129/593 - (21%)
Similarity:207/593 - (34%) Gaps:218/593 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   834 CVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRH-------- 890
            ||::      |:.:.|:|  :|.:.       |.:||||:|:.::|.:|.|:..::.        
Human    17 CVIQ------EKQYEVII--VPTLL-------VTIFLILLGVILWLFIREQRTQQQRSGPQGIAP 66

  Fly   891 ------------------LALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENL-K 936
                              |.||...:.||    :|...|.|.            :.:.|||.| :
Human    67 VPPPRDLSWEAGHGGNVALPLKETSVENF----LGATTPALA------------KLQVPREQLSE 115

  Fly   937 LGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVN 1001
            :.:|:.:|:.|.:.:.........:| .:|.:|.:|..|....|:..:..::...:||:|.|:|.
Human   116 VLEQICSGSCGPIFRANMNTGDPSKP-KSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQ 179

  Fly  1002 LLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHR 1066
            |.|..|:   |..|.:::|....|::.:||...|:               .:||.          
Human   180 LEGCCTE---KLPLYMVLEDVAQGDLLSFLWTCRR---------------DVMTM---------- 216

  Fly  1067 DTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDT 1131
                .||.|                                                        
Human   217 ----DGLLY-------------------------------------------------------- 221

  Fly  1132 CATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHG 1196
                                          |.||.      .:.....||...:::|..|.:.||
Human   222 ------------------------------DLTEK------QVYHIGKQVLLALEFLQEKHLFHG 250

  Fly  1197 DLAARNILLCEDNVVKICDFGLARSMY-RGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSY 1260
            |:||||||:..|...|:|..|||..:| ||   ..|....:|:||||.|.|.....|..:||||:
Human   251 DVAARNILMQSDLTAKLCGLGLAYEVYTRG---AISSTQTIPLKWLAPERLLLRPASIRADVWSF 312

  Fly  1261 GIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAEL 1325
            ||:|:||.:|...|||.:.|. .:...|.....|::|......:|.||..|||.....||...||
Human   313 GILLYEMVTLGAPPYPEVPPT-SILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPREL 376

  Fly  1326 EKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIR 1390
            ..|....:                         ::.|..|::..|:.:.|.....|.|     ||
Human   377 RLRLEAAI-------------------------KTADDEAVLQVPELVVPELYAAVAG-----IR 411

  Fly  1391 IEELPDDY 1398
            :|.|..:|
Human   412 VESLFYNY 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653
Ig strand C 363..366 CDD:409353
Ig strand E 396..400 CDD:409353
Ig strand F 410..415 CDD:409353
Ig strand G 425..428 CDD:409353
Ig 458..533 CDD:472250
Ig strand B 459..463 CDD:409353
Ig strand C 472..476 CDD:409353
Ig strand E 497..503 CDD:409353
Ig strand F 513..518 CDD:409353
Ig 671..>742 CDD:472250
Ig strand B 674..678 CDD:409353
Ig strand C 687..691 CDD:409353
Ig strand E 717..721 CDD:409353
Ig strand F 731..736 CDD:409353
Ig 779..851 CDD:472250 4/16 (25%)
Ig strand B 781..785 CDD:409570
Ig strand C 794..798 CDD:409570
Ig strand E 816..821 CDD:409570
Ig strand F 831..836 CDD:409570 1/1 (100%)
Ig strand G 844..847 CDD:409570 1/2 (50%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 95/406 (23%)
STYK1NP_060893.2 Protein Kinases, catalytic domain 118..381 CDD:473864 91/391 (23%)
Blue background indicates that the domain is not in the aligned region.

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