DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Flt1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	1533	Identity:	406/1533 - (26%)
Similarity:	629/1533 - (41%)	Gaps:	362/1533 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPA----RPFGTSLHLIEVTADYVAAYY 117
            ::.|..:..|||..:...||....:.....|....|....    |.|.::|.|....|::...|.
  Rat    42 VMQAGQTLFLKCRGEAAHSWSLPTTVSQEDKKLSVTRSACGRNNRQFCSTLTLNMAQANHTGLYS 106

  Fly   118 CVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHN----VVTARQYTDVVIP 178
            |....|  ..:||::.:            |:||::|:|..:..::.|:    :|...:..:::||
  Rat   107 CRYLPK--STSKEKKME------------SAIYIFVSDAGSPFIEMHSDIPKLVHMTEGRELIIP 157

  Fly   179 CKPAMPDTEVLLE-------TSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHN 236
            |:...|:..|.|:       |.:|:..:      :|.:|||.|
  Rat   158 CRVTSPNITVTLKKFPFDALTPDGQRIA------WDSRRGFII---------------------- 194

  Fly   237 EEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRE 301
                                   .|..|          .|:..:|.::|.|..|.:      :..
  Rat   195 -----------------------ANATY----------KEIGLLTCEATVNGHLYQ------TSY 220

  Fly   302 RARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWF 366
            ...|....:..:..||           |.||       .........|:|..:..:.:...|.|.
  Rat   221 LTHRQTNTILDVQISP-----------PSPV-------RFLRGQTLVLNCTVTTDLNTRVQMSWN 267

  Fly   367 TPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIK 431
            .|.:...|....| |.|....:|  ....|.|.:.|.:..|.|||.|.....|:..    |:...
  Rat   268 YPGKATKRASIRQ-RIDQSNPHS--NVFHSVLKINNVESRDKGLYTCRVKSGSSFR----TFNTS 325

  Fly   432 VLKQNESYLNVGEPSGHYNVQE--YANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILS 494
            |....:.:::|....  ..|||  ...|:.:::...:.||:|...|.| ||....:....:.:..
  Rat   326 VHVYEKGFISVKHRK--QQVQETIAGKRSHRLSMKVKAFPSPEVVWLK-DGVPATEKSARYSVHG 387

  Fly   495 TELSTMLQVLNAQLQDSGTYV----LRGSNSF---------GVVQREYNVSVMDAPALKMSDAYV 546
            ..|.    :.:...:|:|.|.    ::.|..|         .|..:.|..||...|    |....
  Rat   388 YSLI----IKDVTAEDAGDYTILLGIKQSKLFRNLTATLIVNVKPQIYEKSVSSLP----SPPLY 444

  Fly   547 QVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSV 611
            .:||...|.|||...|...:.:.:.||....     |....:|...|| |.:...:....|. .:
  Rat   445 PLGSRQVLTCTVYGIPQPTIKWLWHPCHYNH-----SKERNDFCFGSE-ESFILDSSSNIGN-RI 502

  Fly   612 ERIYE-----------VSFL----PTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIY- 660
            |.|.:           ||.|    ...|||.:|               ||...:|.:..::..|
  Rat   503 EGITQRMMVIEGTNKTVSTLVVADSRTPGIYSC---------------KAFNKIGTVERDIRFYV 552

  Fly   661 -----GFDKD-HKIAKE-DNVNFTCEALAYHFDGNLKWF----INGEDLKESDSVHIETSHTKYS 714
                 ||... .||..| :::..:|....:.: .::.|.    :|...:..|.|.....:...||
  Rat   553 TDVPNGFHVSLEKIPTEGEDLKLSCVVSKFLY-RDITWILLRTVNNRTMHHSISKQKMATTQDYS 616

  Fly   715 YKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREI----DLYVHDPSAPQWTNGGQEGHSKIKR 775
            ....:.|..:|..|.|||.|||.:     :|:..||    ::.|.|..||...    :..|..:.
  Rat   617 ITLNLVIKNVSLEDSGTYACRARN-----IYTGEEILRKTEVLVRDLEAPLLL----QNLSDHEV 672

  Fly   776 KLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKE---------SKLLITHLYPGDEGV 831
            .:|.:..|:|.:..||...:.|||::         |.|::|         |.|.|..:...||||
  Rat   673 SISGSTTLDCQARGVPAPQITWFKNN---------HKIQQEPGIILGPGNSTLFIERVTEEDEGV 728

  Fly   832 YKCVVENRLDRIERSFTVVI------SDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKR- 889
            |:|...|:...:|.|..:.:      |:|..|::........||.:|:.|.:....|...|.|.
  Rat   729 YRCRATNQKGVVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTD 793

  Fly   890 HLALKAAGLANFEEGAVGHINPD-LTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKG 952
            :|::              .::|| :.||||.|.|||: .::||.||.|||||.||.||||.|::.
  Rat   794 YLSI--------------IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQA 844

  Fly   953 EAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMV 1017
            .|.||::.....||||||:|..|.....:||::||||:.|:|.||||||||||.||.  ...|||
  Rat   845 SAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQ--GGPLMV 907

  Fly  1018 IVEYCRFGNIQNFLLRNRKCFINQINPDTD-HIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFP 1081
            |||||::||:.|:|...|..|.  :|.|.. |::|.  .:::
  Rat   908 IVEYCKYGNLSNYLKSKRDFFC--LNKDAALHMEPK--KEKL----------------------- 945

  Fly  1082 IHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIM 1146
                  ||.....|.|  |.:|.:...|.|.:|        :..|:.:...        |..:..
  Rat   946 ------EPDLEQDQKP--RLDSVSSSESFTSSG--------FQEDKSVSDV--------EGGEDY 986

  Fly  1147 SNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVV 1211
            |..|.||               :|..||||::|||||||::|||:|.:|.|||||||||.|:|||
  Rat   987 SEISKQP---------------LTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVV 1036

  Fly  1212 KICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYP 1276
            |||||||||.:|:..:|.:..:.:||:||:|.||:.|.|:||.|||||||::|||:|||...|||
  Rat  1037 KICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYP 1101

  Fly  1277 GIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV---A 1338
            |:..:::..::|.:|.||..|::|..|:|:|||:||.|:|:.||.||||.::..::|..:|   .
  Rat  1102 GVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDG 1166

  Fly  1339 SHYLDLN-----NPYMQSNI-----EYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIR--- 1390
            ..|:.||     |.....::     ::.|...||.....||.|::     ||||......:.
  Rat  1167 KDYIPLNAILTRNSGFTYSVPTFSEDFFKDGFTDPKFHSGSSDDV-----RYVNAFKFMSLERIK 1226

  Fly  1391 -IEELPDDYMEMSRDSDPDACTAIFSP-------TRLEGESSDFPDFSSETTFNFPGARQSPTLS 1447
             .|||..:...|..|...|..:.:.||       |..:.::|...|....:.....|....|..|
  Rat  1227 TFEELSPNATSMFEDYHLDTSSLLTSPLLKRFTWTETKPKASMKIDLRITSKSKEAGLSDLPGPS 1291

  Fly  1448 NNLNS-GSSKPLRKKNGMPTVDVADQAPEEIPMLHRSS 1484
            ...:| |..:|:|            |..|:.|.|.:.|
  Rat  1292 FCFSSCGHIRPVR------------QEDEDDPELGKES 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	20/85 (24%)
		Ig	<363..432	CDD:299845	18/68 (26%)
		Ig	466..533	CDD:299845	15/79 (19%)
		IG_like	672..754	CDD:214653	19/89 (21%)
		Ig	674..739	CDD:143165	16/68 (24%)
		IGc2	779..840	CDD:197706	20/69 (29%)
		PKc_like	927..1332	CDD:304357	170/405 (42%)
		Pkinase_Tyr	935..1329	CDD:285015	166/394 (42%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653	21/142 (15%)
		IG_like	237..328	CDD:214653	24/104 (23%)
		Ig	245..327	CDD:299845	20/88 (23%)
		Ig	353..424	CDD:299845	13/75 (17%)
		IG_like	439..552	CDD:214653	29/138 (21%)
		Ig	451..549	CDD:143165	25/119 (21%)
		IG	568..640	CDD:214652	17/72 (24%)
		IGc2	569..640	CDD:197706	17/71 (24%)
		I-set	661..748	CDD:254352	25/99 (25%)
		IGc2	676..738	CDD:197706	20/70 (29%)
		PKc_like	819..1157	CDD:304357	170/405 (42%)
		Pkinase_Tyr	827..1154	CDD:285015	166/394 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1517
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1779
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830