DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and FGFRL1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_024309860.1	Gene:	FGFRL1 / 53834	HGNCID:	3693	Length:	527	Species:	Homo sapiens

Alignment Length:	482	Identity:	104/482 - (21%)
Similarity:	155/482 - (32%)	Gaps:	189/482 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 RTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNS 521
            ||:::....||.|.|...|.| ||..:....:.|::|...    |:|...:.:|:|.||.:.:|.
Human    68 RTVRLQCPVEGDPPPLTMWTK-DGRTIHSGWSRFRVLPQG----LKVKQVEREDAGVYVCKATNG 127

  Fly   522 FGVVQREYNVSVMD-------------------APA------------LKMSDAYV--QVGSVAR 553
            ||.:...|.:.|:|                   .||            .||....:  .|||..|
Human   128 FGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVR 192

  Fly   554 LECTVRSYPPAIVTF------FFRPCSLEP---QWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKL 609
            |:|....:|...:|:      ..||.:.||   :| |.|:.|..   |.:..||..:...|.|
Human   193 LKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKW-TLSLKNLR---PEDSGKYTCRVSNRAG-- 251

  Fly   610 SVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTI-YGFDKDHKIAKEDN 673
            ::...|:|..:                   :||.:|. ||.|....|.|: :|          ..
Human   252 AINATYKVDVI-------------------QRTRSKP-VLTGTHPVNTTVDFG----------GT 286

  Fly   674 VNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYH 738
            .:|.|:..:              |:|                      ..|....|..|.....|
Human   287 TSFQCKVRS--------------DVK----------------------PVIQWLKRVEYGAEGRH 315

  Fly   739 NDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKE 803
            |.        .||:            |||:                  ...:|...| |.:.|..
Human   316 NS--------TIDV------------GGQK------------------FVVLPTGDV-WSRPDGS 341

  Fly   804 VTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERS-FTVVISD--LPG--------- 856
            ..           :|||||.....|.|:|.|:..|.:....|| |..|:.|  .||
Human   342 YL-----------NKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSA 395

  Fly   857 ISMAW-VWFGV------ILFLILIGLC 876
            .|:.| |..|:      ||..:|:.||
Human   396 TSLPWPVVIGIPAGAVFILGTLLLWLC 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	20/66 (30%)
		IG_like	672..754	CDD:214653	11/81 (14%)
		Ig	674..739	CDD:143165	7/64 (11%)
		IGc2	779..840	CDD:197706	14/60 (23%)
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
FGFRL1	XP_024309860.1	I-set	56..139	CDD:254352	22/75 (29%)
		Ig2_FGFRL1-like	180..261	CDD:143264	23/86 (27%)
		Ig	284..378	CDD:325142	32/189 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900