DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and PDGFRB

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_002600.1 Gene:PDGFRB / 5159 HGNCID:8804 Length:1106 Species:Homo sapiens


Alignment Length:1566 Identity:365/1566 - (23%)
Similarity:588/1566 - (37%) Gaps:522/1566 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTT 65
            :|:...|:||.|||:|....|..:                       ::||....::|:..::..
Human    10 LALKGELLLLSLLLLLEPQISQGL-----------------------VVTPPGPELVLNVSSTFV 51

  Fly    66 LKCEDDEPMSW--WTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIA 128
            |.|....|:.|  .:.:......|:.|.|      |.:.|.|..:|......|:|....     :
Human    52 LTCSGSAPVVWERMSQEPPQEMAKAQDGT------FSSVLTLTNLTGLDTGEYFCTHND-----S 105

  Fly   129 KEEQSDEAMIELVNQGYASSIYVYVNDPDTKLV--DSHNV-VTARQYTDVVIPCKPAMPDTEVLL 190
            :..::||          ...:|::|.||....:  |:..: :...:.|::.|||:...|...|.|
Human   106 RGLETDE----------RKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTL 160

  Fly   191 ETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIP 255
            ....|::.....   ||.||||:    .|.:...|.|:            |:|..|.:       
Human   161 HEKKGDVALPVP---YDHQRGFS----GIFEDRSYICK------------TTIGDREV------- 199

  Fly   256 RTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPR 320
               .::..|.|...|:..:..|..|.       .::|.|:                         
Human   200 ---DSDAYYVYRLQVSSINVSVNAVQ-------TVVRQGE------------------------- 229

  Fly   321 PGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPK 385
                                     |.||.|  ......|...||..|.::..|:.  :..||..
Human   230 -------------------------NITLMC--IVIGNEVVNFEWTYPRKESGRLV--EPVTDFL 265

  Fly   386 TRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYN 450
            .....|.  ||.|.:.:|:..|:|.|.|..|::.|.:.......|.|::.....| :||......
Human   266 LDMPYHI--RSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRL-LGEVGTLQF 327

  Fly   451 VQEYANRTIQMTANFEGFPTPSFSWFKPDGT-------EVRQSENNFKILSTELSTMLQVLNAQL 508
            .:.:.:||:|:.  ||.:|.|:..|||.:.|       |:..|..|  :..|...:.|.::..::
Human   328 AELHRSRTLQVV--FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRN--VSETRYVSELTLVRVKV 388

  Fly   509 QDSGTYVLRGSNSFGVVQREYNVSV-MDAPALKMSDAYVQVGSVARLECTVRSYP-PAIVTFFFR 571
            .::|.|.:|..:....||..:.:.: :....|::|:::...|. ..:.|..|..| |.|:     
Human   389 AEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGE-QTVRCRGRGMPQPNII----- 447

  Fly   572 PCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIID 636
                   |..|..|.:   .|.|                         ||.              
Human   448 -------WSACRDLKR---CPRE-------------------------LPP-------------- 463

  Fly   637 GKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKES 701
                       .||||.||          .:...|.||.:              |    |:.:|.
Human   464 -----------TLLGNSSE----------EESQLETNVTY--------------W----EEEQEF 489

  Fly   702 DSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGG 766
            :.|            ||:               |..|.|:                         
Human   490 EVV------------STL---------------RLQHVDR------------------------- 502

  Fly   767 QEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESK--LLITHLYPGDE 829
                         .|.:.|.                      ||:.:.::::  :::.|..|   
Human   503 -------------PLSVRCT----------------------LRNAVGQDTQEVIVVPHSLP--- 529

  Fly   830 GVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALK 894
              :|              .||||.:    :|.|...:|..:|||.|       :||:.:..:..|
Human   530 --FK--------------VVVISAI----LALVVLTIISLIILIML-------WQKKPRYEIRWK 567

  Fly   895 AAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRR 959
            .....:.:.....:::|        ..|||:..:|.||:.|.||:.||:||||.|::..|.|:..
Human   568 VIESVSSDGHEYIYVDP--------MQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH 624

  Fly   960 EEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRF 1024
            .:.|..|||||:|:||.:...:||:||||||.|||.||||||||||.||.   ..:.:|.||||:
Human   625 SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKG---GPIYIITEYCRY 686

  Fly  1025 GNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYAN---VGFPIHSYI 1086
            |::.::|.||:..|:..      |.|     :|...:.||          |:|   ||.|:.|::
Human   687 GDLVDYLHRNKHTFLQH------HSD-----KRRPPSAEL----------YSNALPVGLPLPSHV 730

  Fly  1087 NEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDD-------- 1143
                                    :..|.:..|....|.|..:|       .||..|        
Human   731 ------------------------SLTGESDGGYMDMSKDESVD-------YVPMLDMKGDVKYA 764

  Fly  1144 QIMSNNSVQPAWRSNY----------KTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDL 1198
            .|.|:|.:.|  ..||          .|...|:..::.:||:.:::|||.||::|:||..:|.||
Human   765 DIESSNYMAP--YDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDL 827

  Fly  1199 AARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIV 1263
            ||||:|:||..:||||||||||.:.|..||....:..||:||:|.||:.:.:::|.|||||:||:
Human   828 AARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGIL 892

  Fly  1264 LWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKR 1328
            |||:|:|...|||.:..|::.:|.:..||||.:|..|:.|:||||.:||.:..|.||.|::|...
Human   893 LWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLL 957

  Fly  1329 FANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYV--------NGHI 1385
            ...:|||.....|..::..:::|:...:.:.........|....|..::..|.        |.:|
Human   958 LERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYI 1022

  Fly  1386 VPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNL 1450
            :|      |||...|:: |..|           |||.    |..:|.|.             |.:
Human  1023 IP------LPDPKPEVA-DEGP-----------LEGS----PSLASSTL-------------NEV 1052

  Fly  1451 NSGSS----KPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPS 1511
            |:.|:    .||..::          .||..|.|...   .:..||        |:|...:..|:
Human  1053 NTSSTISCDSPLEPQD----------EPEPEPQLELQ---VEPEPE--------LEQLPDSGCPA 1096

  Fly  1512 PRHHVE 1517
            ||...|
Human  1097 PRAEAE 1102

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 23/85 (27%)
Ig <363..432 CDD:299845 18/68 (26%)
Ig 466..533 CDD:299845 17/73 (23%)
IG_like 672..754 CDD:214653 11/81 (14%)
Ig 674..739 CDD:143165 8/64 (13%)
IGc2 779..840 CDD:197706 7/62 (11%)
PKc_like 927..1332 CDD:304357 160/425 (38%)
Pkinase_Tyr 935..1329 CDD:285015 157/414 (38%)
PDGFRBNP_002600.1 ig 37..114 CDD:278476 17/97 (18%)
IG 40..110 CDD:214652 14/80 (18%)
IG_like 222..310 CDD:214653 25/150 (17%)
Ig1_PDGFR-alphabeta 228..312 CDD:143269 25/139 (18%)
Ig4_PDGFR-alpha 314..415 CDD:143267 24/105 (23%)
Ig 425..523 CDD:299845 35/278 (13%)
PTKc_PDGFR_beta 562..953 CDD:133238 164/455 (36%)
Pkinase_Tyr 600..953 CDD:285015 156/409 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1106 32/140 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41363
orthoMCL 1 0.900 - - OOG6_106773
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4986
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.750

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