DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and PDGFRL

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001359002.1	Gene:	PDGFRL / 5157	HGNCID:	8805	Length:	375	Species:	Homo sapiens

Alignment Length:	344	Identity:	62/344 - (18%)
Similarity:	101/344 - (29%)	Gaps:	115/344 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 AYYCVKTSKFSQIAKEEQSDEAMIELVN----------------QGY--------ASSIYVYVND 155
            ||  :.|.|.|:::.::......:.|||                .||        ..|.|::..:
Human   107 AY--LDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTE 169

  Fly   156 PDTKLVDS---HNVVTARQYTDVVIPCKPAMPDTEVLL--ETSNGEMHSSKSVGRYDPQRGFTIE 215
            .....|.|   .:||........|:||:..:...:|.|  |....|:.::.:...||.:|||...
Human   170 KGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL 234

  Fly   216 IRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTV 280
            .......|..|||.      .....:.|.|::....:.:|....:..:...:..|..|||..:..
Human   235 QPHSEHQGVVYCRA------EAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLC 293

  Fly   281 TNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDT 345
            |                                             .|.:|.:          :.
Human   294 T---------------------------------------------VLGEPDV----------EV 303

  Fly   346 NFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQT--GRSTLTVLNAQPSDT 408
            .||                |..|.:.:.|....|.......|...|.|  .:|.:||.:.:..|.
Human   304 EFT----------------WIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDA 352

  Fly   409 GLYKCVTTDNSNQNVQRAT 427
            |.|.|..     ||:|..|
Human   353 GYYICTA-----QNLQGQT 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	20/84 (24%)
		Ig	<363..432	CDD:299845	18/67 (27%)
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
PDGFRL	NP_001359002.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
		IG_like	83..145	CDD:214653	8/39 (21%)
		Ig	293..372	CDD:386229	23/150 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900