DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and PDGFRA

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_001334757.1 Gene:PDGFRA / 5156 HGNCID:8803 Length:1114 Species:Homo sapiens


Alignment Length:1518 Identity:355/1518 - (23%)
Similarity:572/1518 - (37%) Gaps:519/1518 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MLPRLILLPLLLILRISWSDAVPLQQFSPDPDD------------------SIENCGGENGAPLM 49
            |||||:|        .||:..:.|.|....|..                  |:..|  :...|.:
Human     1 MLPRLVL--------NSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILC--QLSLPSI 55

  Fly    50 TPCKSAIILDAQTSTTLKCEDDEPMSWW----TSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTA 110
            .|.::..::...:|.:|:|..:..:||.    ..:|..|.::   |.|:.:..|.|.|.:...:|
Human    56 LPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIR---NEENNSGLFVTVLEVSSASA 117

  Fly   111 DYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVD---SHNVVTARQY 172
            .:...|.|.    ::....||          |:.....||:||.|||...|.   :..:|.....
Human   118 AHTGLYTCY----YNHTQTEE----------NELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDD 168

  Fly   173 TDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGF--TIEIRSIVDGGDYYCRPNPPFPH 235
            ...:|||:...|:|.|.|..|.|.:.:|     ||.::||  |..:      |.|.|        
Human   169 DSAIIPCRTTDPETPVTLHNSEGVVPAS-----YDSRQGFNGTFTV------GPYIC-------- 214

  Fly   236 NEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSR 300
               |.|....:|        :|...|:....|....|.:.|.|                      
Human   215 ---EATVKGKKF--------QTIPFNVYALKATSELDLEMEAL---------------------- 246

  Fly   301 ERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEW 365
                                         |.|.:|.        ....:.|  :.:...|..::|
Human   247 -----------------------------KTVYKSG--------ETIVVTC--AVFNNEVVDLQW 272

  Fly   366 FTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRI 430
            ..|...:.:...........:....:     ||||..|...|:|.|:|.        .::||..:
Human   273 TYPGEVKGKGITMLEEIKVPSIKLVY-----TLTVPEATVKDSGDYECA--------ARQATREV 324

  Fly   431 KVLKQ------NESYLNVGEPS----GHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQ 485
            |.:|:      .:.::.: :|:    ...|:.|..:..:::.|    :|.|..||.|        
Human   325 KEMKKVTISVHEKGFIEI-KPTFSQLEAVNLHEVKHFVVEVRA----YPPPRISWLK-------- 376

  Fly   486 SENNFKILS--TELST------------MLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDA 536
              ||..::.  ||::|            .|:::.|:.:|||.|.:                    
Human   377 --NNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTI-------------------- 419

  Fly   537 PALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQ 601
                          ||:.|..|:||     ||                                 
Human   420 --------------VAQNEDAVKSY-----TF--------------------------------- 432

  Fly   602 TRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDH 666
                                   .:||.:..:|:|            |:            |..|
Human   433 -----------------------ELLTQVPSSILD------------LV------------DDHH 450

  Fly   667 KIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGT 731
            .......|..|.|....   .:::|.| .:|:|:.::   |||.|..:...:..||.|..|||.|
Human   451 GSTGGQTVRCTAEGTPL---PDIEWMI-CKDIKKCNN---ETSWTILANNVSNIITEIHSRDRST 508

  Fly   732 YECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVR 796
            .|.|...                                    .|:.:|:.:.|.:         
Human   509 VEGRVTF------------------------------------AKVEETIAVRCLA--------- 528

  Fly   797 WFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAW 861
                         ::::..|::.|            |.|...    :....||..:.|       
Human   529 -------------KNLLGAENREL------------KLVAPT----LRSELTVAAAVL------- 557

  Fly   862 VWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPD----LTLDEQAELL 922
                |:|.:::|.|.|.:.:..||..           .......:..|:||    :.:|...  |
Human   558 ----VLLVIVIISLIVLVVIWKQKPR-----------YEIRWRVIESISPDGHEYIYVDPMQ--L 605

  Fly   923 PYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSEL 987
            ||:..:||||:.|.||:.||:||||.|::|.|.|:.|.:|...|||||:|.||.:...:||:|||
Human   606 PYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 670

  Fly   988 KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPS 1052
            |||.|||.|||:||||||.||:   ..:.:|.|||.:|::.|:|.:||..|::. :|:....:..
Human   671 KIMTHLGPHLNIVNLLGACTKS---GPIYIITEYCFYGDLVNYLHKNRDSFLSH-HPEKPKKELD 731

  Fly  1053 IMTQRMSD----NYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQ--PPTHRRNSDNDPRSGT 1111
            |.....:|    :|.:        |.:.|.|    .|::....:.||  |...|:.         
Human   732 IFGLNPADESTRSYVI--------LSFENNG----DYMDMKQADTTQYVPMLERKE--------- 775

  Fly  1112 RAGRTGSGTATYS------YDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVT 1170
                    .:.||      |||.    |:.......|.::          ::....|::|.:|: 
Human   776 --------VSKYSDIQRSLYDRP----ASYKKKSMLDSEV----------KNLLSDDNSEGLTL- 817

  Fly  1171 TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGK 1235
             :||:|:.:||||||::|:||..:|.||||||:||.:..:||||||||||.:....||....:..
Human   818 -LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF 881

  Fly  1236 LPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFA 1300
            ||:||:|.||:.|::::|.||||||||:|||:|||...||||:..:...:||:..||||.||..|
Human   882 LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHA 946

  Fly  1301 NQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTD--- 1362
            ..|:||||::||...||.||.|..|.:...|:|.......|..::..:::|:...:.:...|   
Human   947 TSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDN 1011

  Fly  1363 -YLALM------------GSPDELAPAAPRYVNGHIVPDIRIEELP--DDYMEMSRDSDPDACTA 1412
             |:.:.            |..||...:|.   :|:|:|...|:.:|  :|..:.:|.|...:   
Human  1012 AYIGVTYKNEEDKLKDWEGGLDEQRLSAD---SGYIIPLPDIDPVPEEEDLGKRNRHSSQTS--- 1070

  Fly  1413 IFSPTRLEGESSDFPDFSSETTF 1435
                     |.|.....||.:||
Human  1071 ---------EESAIETGSSSSTF 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 15/85 (18%)
Ig <363..432 CDD:299845 13/68 (19%)
Ig 466..533 CDD:299845 16/80 (20%)
IG_like 672..754 CDD:214653 20/81 (25%)
Ig 674..739 CDD:143165 20/64 (31%)
IGc2 779..840 CDD:197706 6/60 (10%)
PKc_like 927..1332 CDD:304357 163/416 (39%)
Pkinase_Tyr 935..1329 CDD:285015 159/405 (39%)
PDGFRANP_001334757.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 310 1.000 Domainoid score I1325
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41363
orthoMCL 1 0.900 - - OOG6_106773
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6217
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

Return to query results.
Submit another query.