DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and PDGFRA

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_001334757.1 Gene:PDGFRA / 5156 HGNCID:8803 Length:1114 Species:Homo sapiens


Alignment Length:1518 Identity:355/1518 - (23%)
Similarity:572/1518 - (37%) Gaps:519/1518 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MLPRLILLPLLLILRISWSDAVPLQQFSPDPDD------------------SIENCGGENGAPLM 49
            |||||:|        .||:..:.|.|....|..                  |:..|  :...|.:
Human     1 MLPRLVL--------NSWAQMICLPQLPKFPRAMGTSHPAFLVLGCLLTGLSLILC--QLSLPSI 55

  Fly    50 TPCKSAIILDAQTSTTLKCEDDEPMSWW----TSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTA 110
            .|.::..::...:|.:|:|..:..:||.    ..:|..|.::   |.|:.:..|.|.|.:...:|
Human    56 LPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIR---NEENNSGLFVTVLEVSSASA 117

  Fly   111 DYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVD---SHNVVTARQY 172
            .:...|.|.    ::....||          |:.....||:||.|||...|.   :..:|.....
Human   118 AHTGLYTCY----YNHTQTEE----------NELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDD 168

  Fly   173 TDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGF--TIEIRSIVDGGDYYCRPNPPFPH 235
            ...:|||:...|:|.|.|..|.|.:.:|     ||.::||  |..:      |.|.|        
Human   169 DSAIIPCRTTDPETPVTLHNSEGVVPAS-----YDSRQGFNGTFTV------GPYIC-------- 214

  Fly   236 NEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSR 300
               |.|....:|        :|...|:....|....|.:.|.|                      
Human   215 ---EATVKGKKF--------QTIPFNVYALKATSELDLEMEAL---------------------- 246

  Fly   301 ERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEW 365
                                         |.|.:|.        ....:.|  :.:...|..::|
Human   247 -----------------------------KTVYKSG--------ETIVVTC--AVFNNEVVDLQW 272

  Fly   366 FTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRI 430
            ..|...:.:...........:....:     ||||..|...|:|.|:|.        .::||..:
Human   273 TYPGEVKGKGITMLEEIKVPSIKLVY-----TLTVPEATVKDSGDYECA--------ARQATREV 324

  Fly   431 KVLKQ------NESYLNVGEPS----GHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQ 485
            |.:|:      .:.::.: :|:    ...|:.|..:..:::.|    :|.|..||.|        
Human   325 KEMKKVTISVHEKGFIEI-KPTFSQLEAVNLHEVKHFVVEVRA----YPPPRISWLK-------- 376

  Fly   486 SENNFKILS--TELST------------MLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDA 536
              ||..::.  ||::|            .|:::.|:.:|||.|.:                    
Human   377 --NNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTI-------------------- 419

  Fly   537 PALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQ 601
                          ||:.|..|:||     ||                                 
Human   420 --------------VAQNEDAVKSY-----TF--------------------------------- 432

  Fly   602 TRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDH 666
                                   .:||.:..:|:|            |:            |..|
Human   433 -----------------------ELLTQVPSSILD------------LV------------DDHH 450

  Fly   667 KIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGT 731
            .......|..|.|....   .:::|.| .:|:|:.::   |||.|..:...:..||.|..|||.|
Human   451 GSTGGQTVRCTAEGTPL---PDIEWMI-CKDIKKCNN---ETSWTILANNVSNIITEIHSRDRST 508

  Fly   732 YECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVR 796
            .|.|...                                    .|:.:|:.:.|.:         
Human   509 VEGRVTF------------------------------------AKVEETIAVRCLA--------- 528

  Fly   797 WFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAW 861
                         ::::..|::.|            |.|...    :....||..:.|       
Human   529 -------------KNLLGAENREL------------KLVAPT----LRSELTVAAAVL------- 557

  Fly   862 VWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPD----LTLDEQAELL 922
                |:|.:::|.|.|.:.:..||..           .......:..|:||    :.:|...  |
Human   558 ----VLLVIVIISLIVLVVIWKQKPR-----------YEIRWRVIESISPDGHEYIYVDPMQ--L 605

  Fly   923 PYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSEL 987
            ||:..:||||:.|.||:.||:||||.|::|.|.|:.|.:|...|||||:|.||.:...:||:|||
Human   606 PYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 670

  Fly   988 KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPS 1052
            |||.|||.|||:||||||.||:   ..:.:|.|||.:|::.|:|.:||..|::. :|:....:..
Human   671 KIMTHLGPHLNIVNLLGACTKS---GPIYIITEYCFYGDLVNYLHKNRDSFLSH-HPEKPKKELD 731

  Fly  1053 IMTQRMSD----NYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQ--PPTHRRNSDNDPRSGT 1111
            |.....:|    :|.:        |.:.|.|    .|::....:.||  |...|:.         
Human   732 IFGLNPADESTRSYVI--------LSFENNG----DYMDMKQADTTQYVPMLERKE--------- 775

  Fly  1112 RAGRTGSGTATYS------YDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVT 1170
                    .:.||      |||.    |:.......|.::          ::....|::|.:|: 
Human   776 --------VSKYSDIQRSLYDRP----ASYKKKSMLDSEV----------KNLLSDDNSEGLTL- 817

  Fly  1171 TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGK 1235
             :||:|:.:||||||::|:||..:|.||||||:||.:..:||||||||||.:....||....:..
Human   818 -LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF 881

  Fly  1236 LPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFA 1300
            ||:||:|.||:.|::::|.||||||||:|||:|||...||||:..:...:||:..||||.||..|
Human   882 LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHA 946

  Fly  1301 NQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTD--- 1362
            ..|:||||::||...||.||.|..|.:...|:|.......|..::..:::|:...:.:...|   
Human   947 TSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDN 1011

  Fly  1363 -YLALM------------GSPDELAPAAPRYVNGHIVPDIRIEELP--DDYMEMSRDSDPDACTA 1412
             |:.:.            |..||...:|.   :|:|:|...|:.:|  :|..:.:|.|...:   
Human  1012 AYIGVTYKNEEDKLKDWEGGLDEQRLSAD---SGYIIPLPDIDPVPEEEDLGKRNRHSSQTS--- 1070

  Fly  1413 IFSPTRLEGESSDFPDFSSETTF 1435
                     |.|.....||.:||
Human  1071 ---------EESAIETGSSSSTF 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 15/85 (18%)
Ig strand C 363..366 CDD:409353 0/2 (0%)
Ig strand E 396..400 CDD:409353 2/3 (67%)
Ig strand F 410..415 CDD:409353 2/4 (50%)
Ig strand G 425..428 CDD:409353 1/2 (50%)
Ig 458..533 CDD:472250 17/88 (19%)
Ig strand B 459..463 CDD:409353 0/3 (0%)
Ig strand C 472..476 CDD:409353 1/3 (33%)
Ig strand E 497..503 CDD:409353 2/17 (12%)
Ig strand F 513..518 CDD:409353 1/4 (25%)
Ig 671..>742 CDD:472250 20/70 (29%)
Ig strand B 674..678 CDD:409353 1/3 (33%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 0/3 (0%)
Ig strand F 731..736 CDD:409353 2/4 (50%)
Ig 779..851 CDD:472250 8/71 (11%)
Ig strand B 781..785 CDD:409570 0/3 (0%)
Ig strand C 794..798 CDD:409570 0/3 (0%)
Ig strand E 816..821 CDD:409570 1/4 (25%)
Ig strand F 831..836 CDD:409570 1/4 (25%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 163/416 (39%)
PDGFRANP_001334757.1 Ig_3 53..125 CDD:464046 16/74 (22%)
IgI_PDGFR-alphabeta 237..335 CDD:409447 23/171 (13%)
Ig strand A 237..241 CDD:409447 0/3 (0%)
Ig strand A' 248..252 CDD:409447 1/3 (33%)
Ig strand B 254..263 CDD:409447 1/10 (10%)
Ig strand C 268..273 CDD:409447 0/4 (0%)
Ig strand C' 276..278 CDD:409447 0/1 (0%)
Ig strand D 282..290 CDD:409447 0/7 (0%)
Ig strand E 294..302 CDD:409447 2/12 (17%)
Ig strand F 312..318 CDD:409447 2/13 (15%)
Ig strand G 323..329 CDD:409447 1/5 (20%)
Ig4_PDGFR 338..438 CDD:409445 30/209 (14%)
PTKc_PDGFR_alpha 580..981 CDD:173653 172/451 (38%)

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