DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and ROR1

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:1251 Identity:260/1251 - (20%)
Similarity:394/1251 - (31%) Gaps:482/1251 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   419 SNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEV 483
            |.:.|..:::.|......:|||.:.||..  |:.....:|.::.....|.|.|:..|||.|...|
Human    37 SAELVPTSSWNISSELNKDSYLTLDEPMN--NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVV 99

  Fly   484 RQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQV 548
             |........||...:.|::.|....|:|.:....:|...||.   :..|:          :|:.
Human   100 -QEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVS---STGVL----------FVKF 150

  Fly   549 GSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVER 613
            |            ||                ||.|        |...::|:              
Human   151 G------------PP----------------PTAS--------PGYSDEYE-------------- 165

  Fly   614 IYEVSFLPTEPGIL--------TCIAQNI-IDGKERRTLTKAHVLLGNISE-----------NMT 658
              |..|.....||.        |...::: :.|:....:|.|..::|..|.           ::.
Human   166 --EDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLC 228

  Fly   659 IYGF---DKDHKIAK-EDNVNFTCEAL-------AYHFDGNLKWFI------NGEDLKESDSVH- 705
            .|.|   |:...:.| .|.....||.|       .|.|..:....:      |.|||.:.:|.. 
Human   229 HYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEA 293

  Fly   706 -------------IETSHTKYS-----YKSTVHIT----------------------TISDRDRG 730
                         |..:|..|:     |:.||.:|                      ...:.:.|
Human   294 ANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGG 358

  Fly   731 TYECRAYHNDKDAV--------YSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECAS 787
            ...||...|.|:|.        :.|...|:...|..           .||.|.|: :.|.:...|
Human   359 HSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSK-----------DSKEKNKM-EILYILVPS 411

  Fly   788 TAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVIS 852
            .|:|:||...|                                .:.||..|.    ::|     |
Human   412 VAIPLAIALLF--------------------------------FFICVCRNN----QKS-----S 435

  Fly   853 DLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDE 917
            ..|                         |:.|.:|.|...::.:.|..::               
Human   436 SAP-------------------------VQRQPKHVRGQNVEMSMLNAYK--------------- 460

  Fly   918 QAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGE--AKGIRREEPTTTVAVKMVKATADNEVV 980
                 |.::..|.|...::..::||..|||.:.||.  ..|:   :....||:|.:|...:.:..
Human   461 -----PKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGM---DHAQLVAIKTLKDYNNPQQW 517

  Fly   981 RALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPD 1045
            .....|..:|..| .|.|:|.||||||:   ::.:.::.||...|::..||:..        :|.
Human   518 TEFQQEASLMAEL-HHPNIVCLLGAVTQ---EQPVCMLFEYINQGDLHEFLIMR--------SPH 570

  Fly  1046 TDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSG 1110
            :|                              ||.                     :||.|    
Human   571 SD------------------------------VGC---------------------SSDED---- 580

  Fly  1111 TRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLI 1175
                    ||...|.|..                                            |.:
Human   581 --------GTVKSSLDHG--------------------------------------------DFL 593

  Fly  1176 SWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKW 1240
            ..|.|:|.||:||||...:|.||||||||:.|...|||.|.||:|.:|..|.|:......|||:|
Human   594 HIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRW 658

  Fly  1241 LALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELY 1305
            :..|::....||:.||:||:|:||||:||....||.|.. |||:...:.....:...:.....:|
Human   659 MPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFS-NQEVIEMVRKRQLLPCSEDCPPRMY 722

  Fly  1306 EIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSP 1370
            .:|.|||.:.|..||.|.::..|..:.  |.::||        ..|........:|...:|..||
Human   723 SLMTECWNEIPSRRPRFKDIHVRLRSW--EGLSSH--------TSSTTPSGGNATTQTTSLSASP 777

  Fly  1371 -DELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDF--PDFSSE 1432
             ..|  :.|||.|               ||..|:...|            :|:.:.|  |.....
Human   778 VSNL--SNPRYPN---------------YMFPSQGITP------------QGQIAGFIGPPIPQN 813

  Fly  1433 TTF-------------NFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSS 1484
            ..|             .||.|...||                 |.|.  |....|   |...||.
Human   814 QRFIPINGYPIPPGYAAFPAAHYQPT-----------------GPPR--VIQHCP---PPKSRSP 856

  Fly  1485 TGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKNIPGKTTTGGGGA 1549
            :.:.||...|          :||..||...:.|..:...|     :|..|  |.||         
Human   857 SSASGSTSTG----------HVTSLPSSGSNQEANIPLLP-----HMSIP--NHPG--------- 895

  Fly  1550 AAGASTEAFSNPSYQP 1565
              |.....|.|.|.:|
Human   896 --GMGITVFGNKSQKP 909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 3/12 (25%)
Ig strand C 363..366 CDD:409353
Ig strand E 396..400 CDD:409353
Ig strand F 410..415 CDD:409353
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 19/74 (26%)
Ig strand B 459..463 CDD:409353 0/3 (0%)
Ig strand C 472..476 CDD:409353 0/3 (0%)
Ig strand E 497..503 CDD:409353 1/5 (20%)
Ig strand F 513..518 CDD:409353 0/4 (0%)
Ig 671..>742 CDD:472250 22/124 (18%)
Ig strand B 674..678 CDD:409353 0/3 (0%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 2/3 (67%)
Ig strand F 731..736 CDD:409353 1/4 (25%)
Ig 779..851 CDD:472250 11/71 (15%)
Ig strand B 781..785 CDD:409570 1/3 (33%)
Ig strand C 794..798 CDD:409570 1/3 (33%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 1/4 (25%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 106/406 (26%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653 21/95 (22%)
Ig strand B 75..79 CDD:409570 0/3 (0%)
Ig strand C 88..92 CDD:409570 0/3 (0%)
Ig strand E 114..118 CDD:409570 1/3 (33%)
Ig strand F 128..133 CDD:409570 0/4 (0%)
Ig strand G 141..144 CDD:409570 0/5 (0%)
CRD_TK_ROR1 166..307 CDD:143576 25/140 (18%)
KR 311..393 CDD:214527 14/81 (17%)
PTKc_Ror1 467..749 CDD:270672 106/404 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890 20/93 (22%)
Blue background indicates that the domain is not in the aligned region.

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