DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and NTRK3

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:XP_016877743.1 Gene:NTRK3 / 4916 HGNCID:8033 Length:850 Species:Homo sapiens


Alignment Length:1058 Identity:215/1058 - (20%)
Similarity:367/1058 - (34%) Gaps:368/1058 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   377 ASQSRTDPKTRN--STHQTGRSTLTVLNAQPSD--TGLYKCVTTDNSNQNVQ-RATYRIKVLKQN 436
            ||.:.|| .:||  |.|.....:|..|||...:  |||.|....::..:::| ||..:...|:  
Human    69 ASINITD-ISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLR-- 130

  Fly   437 ESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTM- 500
              |:|:.           :||          ..|.|:..|:.......|.|.||...|.::..| 
Human   131 --YINLS-----------SNR----------LTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQ 172

  Fly   501 --LQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPP 563
              .:...|:|.....|.:....|...:.| .|:|..|.|.:          ||:.:..|||....
Human   173 LWQEQGEAKLNSQNLYCINADGSQLPLFR-MNISQCDLPEI----------SVSHVNLTVREGDN 226

  Fly   564 AIVTFFFRPCS------LEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPT 622
            |::|     |:      .:..|....:.:.|          ..||......:....:..|:....
Human   227 AVIT-----CNGSGSPLPDVDWIVTGLQSIN----------THQTNLNWTNVHAINLTLVNVTSE 276

  Fly   623 EPGI-LTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDK-----DHKIAKEDNVNFTCEAL 681
            :.|. |||||:|::.             :.|.|..:|:|...:     :.::..|..:.|...  
Human   277 DNGFTLTCIAENVVG-------------MSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVR-- 326

  Fly   682 AYHFDGN----LKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKD 742
                 ||    |.|..||:.|:||..:|:|     |..:..:           :..|..:  :|.
Human   327 -----GNPPPTLHWLHNGQPLRESKIIHVE-----YYQEGEI-----------SEGCLLF--NKP 368

  Fly   743 AVYSSREIDLYVHDP--SAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVT 805
            ..|::....|...:|  :|.|..||                                        
Human   369 THYNNGNYTLIAKNPLGTANQTING---------------------------------------- 393

  Fly   806 ESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLP-----GISMAWVWFG 865
                 |.:::          |..|.....::   .|.:..:..:.::..|     |:|:|   .|
Human   394 -----HFLKE----------PFPESTDNFIL---FDEVSPTPPITVTHKPEEDTFGVSIA---VG 437

  Fly   866 VILFLILIGLCVFLAV-RYQKEHKRHLALKAAGLANFEEGA--VGHINPDLTLDEQAELLP---- 923
            :..|..::.:.:|:.: :|.:..|..:....|.::..|:.|  :.|||..:|.....:..|    
Human   438 LAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVV 502

  Fly   924 -------------YNRE-----------FEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTT 964
                         |.|:           ....|.::.|.::||.||||.|...|...:...:...
Human   503 IGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM 567

  Fly   965 TVAVKMVK---ATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGN 1026
            .||||.:|   ..|..:..|    |.:::.:| ||.::|...|.....   ..|:::.||.:.|:
Human   568 LVAVKALKDPTLAARKDFQR----EAELLTNL-QHEHIVKFYGVCGDG---DPLIMVFEYMKHGD 624

  Fly  1027 IQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHN 1091
            :..||..:        .||.     .|:.                                    
Human   625 LNKFLRAH--------GPDA-----MILV------------------------------------ 640

  Fly  1092 NNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWR 1156
                        |..||..  .|..|..                                     
Human   641 ------------DGQPRQA--KGELGLS------------------------------------- 654

  Fly  1157 SNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARS 1221
                            .::..|.|:|.||.||:|:..:|.|||.||.|:..:.:|||.|||::|.
Human   655 ----------------QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRD 703

  Fly  1222 MYRGDNYKKSENGK-------------------------LPIKWLALESLSDHVFSTYSDVWSYG 1261
            :|..|.|::....|                         |||:|:..||:....|:|.|||||:|
Human   704 VYSTDYYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFG 768

  Fly  1262 IVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELE 1326
            ::|||:|:..|.|:..:. |.|:...:..|..:|:|:...:|:|::||.||::.|:.|....|:.
Human   769 VILWEIFTYGKQPWFQLS-NTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIY 832

  Fly  1327 KRFANMLGEDVASHYLDL 1344
            | ..:.||: ....|||:
Human   833 K-ILHALGK-ATPIYLDI 848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 19/59 (32%)
Ig strand C 363..366 CDD:409353
Ig strand E 396..400 CDD:409353 1/3 (33%)
Ig strand F 410..415 CDD:409353 2/4 (50%)
Ig strand G 425..428 CDD:409353 2/2 (100%)
Ig 458..533 CDD:472250 15/77 (19%)
Ig strand B 459..463 CDD:409353 0/3 (0%)
Ig strand C 472..476 CDD:409353 1/3 (33%)
Ig strand E 497..503 CDD:409353 1/8 (13%)
Ig strand F 513..518 CDD:409353 1/4 (25%)
Ig 671..>742 CDD:472250 15/74 (20%)
Ig strand B 674..678 CDD:409353 1/3 (33%)
Ig strand C 687..691 CDD:409353 3/7 (43%)
Ig strand E 717..721 CDD:409353 0/3 (0%)
Ig strand F 731..736 CDD:409353 1/4 (25%)
Ig 779..851 CDD:472250 4/71 (6%)
Ig strand B 781..785 CDD:409570 0/3 (0%)
Ig strand C 794..798 CDD:409570 0/3 (0%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 0/4 (0%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 98/443 (22%)
NTRK3XP_016877743.1 LRR_8 103..160 CDD:404697 17/81 (21%)
leucine-rich repeat 105..128 CDD:275378 5/22 (23%)
leucine-rich repeat 129..151 CDD:275378 8/46 (17%)
leucine-rich repeat 152..164 CDD:275378 4/11 (36%)
LRRCT_2 163..208 CDD:465313 9/45 (20%)
ig 214..299 CDD:395002 21/112 (19%)
Ig strand B 227..231 CDD:409568 2/8 (25%)
Ig strand C 240..244 CDD:409568 0/3 (0%)
Ig strand E 266..270 CDD:409568 0/3 (0%)
Ig strand F 281..286 CDD:409568 3/4 (75%)
Ig strand G 294..297 CDD:409568 1/2 (50%)
IgI_TrKABC_d5 304..396 CDD:409360 24/161 (15%)
Ig strand A 305..311 CDD:409360 0/5 (0%)
Ig strand A' 313..316 CDD:409360 0/2 (0%)
Ig strand B 319..327 CDD:409360 1/14 (7%)
Ig strand C 330..337 CDD:409360 2/6 (33%)
Ig strand C' 340..343 CDD:409360 0/2 (0%)
Ig strand D 348..354 CDD:409360 3/10 (30%)
Ig strand E 358..366 CDD:409360 1/20 (5%)
Ig strand F 374..382 CDD:409360 1/7 (14%)
Ig strand G 385..393 CDD:409360 2/7 (29%)
PTKc_TrkC 532..843 CDD:270676 100/437 (23%)
Blue background indicates that the domain is not in the aligned region.

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