Protein Alignment Pvr and htl

DIOPT Version :10

• Sequence 1: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Sequence 2: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 814
• Identity: 222/814 - (27%)
• Similarity: 320/814 - (39%)
• Gaps: 263/814 - (32%)

  Fly   616 EVSFLPTEPG----ILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNF 676
            ::|||.|.|.    .|.|.|                  |||...|:|.|         :...|::
  Fly   108 KMSFLQTRPSGSLLTLNCHA------------------LGNPEPNITWY---------RNGTVDW 145

  Fly   677 TCEALAYHFDGNLK---WFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECR--- 735
            |   ..|   |:||   |.:..|||...|.                          |.|.|:
  Fly   146 T---RGY---GSLKRNRWTLTMEDLVPGDC--------------------------GNYTCKVCN 178

  Fly   736 ---AYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRW 797
               ...:|...:.|.|    ..|.|..       ..|...:...::.|..:.|...:...:...|
  Fly   179 SLGCIRHDTQVIVSDR----VNHKPIL-------MTGPLNLTLVVNSTGSMHCKYLSDLTSKKAW 232

  Fly   798 -FKDDKEVTE-SKLRHII-EKESKLLITHLYPGDEGVYKCVVENRLD--------RIERSFTVV- 850
             |.....:|. |..|.|| |.:.:|...::....||.|.||..|.|.        |:.||..|:
  Fly   233 IFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLE 297

  Fly   851 ----ISDLPGISMAWVW-FGVILFLILIGLCVFLAVRYQKEH--------------KRHLALKAA 896
                ...|...|..::: ||.::|:.:..|.||.|:|..|..              |:.:..|..
  Fly   298 AGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPE 362

  Fly   897 GLANFEEGAVGHINPDLTLDEQA--------ELLPYNREFEF--------PRENLKLGKQLGAGA 945
            |..:........|.|.:.:.:|.        |..|:| |:||        ||.:|.||..||.||
  Fly   363 GGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EYEFPLDSNWELPRSHLVLGATLGEGA 426

  Fly   946 FGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNI 1010
            ||.|:..|..       ...|||||||....::.:.:||.|:::|..:|:|:|::||||..::|
  Fly   427 FGRVVMAEVN-------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN- 483

  Fly  1011 AKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKY 1075
              ..|.|||||...||:::||.:||     ....|.|                  ||
  Fly   484 --GPLYVIVEYAPHGNLKDFLYKNR-----PFGRDQD------------------RD-------- 515

  Fly  1076 ANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVP 1140
                             ::|||
  Fly   516 -----------------SSQPP------------------------------------------- 520

  Fly  1141 EDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILL 1205
                                 .|..|..:|..|||.:|.|:|||||||:|::.:|.||||||:|:
  Fly   521 ---------------------PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLV 564

  Fly  1206 CEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSL 1270
            .:|.|:||.||||||.:...|.|:|:.||:|||||:|.|||.:..:.:.||||||||:|||:.:.
  Fly   565 SDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTY 629

  Fly  1271 AKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGE 1335
            .:.|||.|...:||:..|..|.|||||...:..:|.:|.:||..|.:.||.|.|:.:....:|
  Fly   630 GQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLL-- 692

  Fly  1336 DVASHYLD-----LNNPYMQSNIEYMKKQSTDYL 1364
            .....|||     |:.|...|:.|   :..||.|
  Fly   693 QTKEDYLDVDIANLDTPPSTSDEE---EDETDNL 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653
		Ig strand C	363..366	CDD:409353
		Ig strand E	396..400	CDD:409353
		Ig strand F	410..415	CDD:409353
		Ig strand G	425..428	CDD:409353
		Ig	458..533	CDD:472250
		Ig strand B	459..463	CDD:409353
		Ig strand C	472..476	CDD:409353
		Ig strand E	497..503	CDD:409353
		Ig strand F	513..518	CDD:409353
		Ig	671..>742	CDD:472250	15/79 (19%)
		Ig strand B	674..678	CDD:409353	1/3 (33%)
		Ig strand C	687..691	CDD:409353	3/6 (50%)
		Ig strand E	717..721	CDD:409353	0/3 (0%)
		Ig strand F	731..736	CDD:409353	2/10 (20%)
		Ig	779..851	CDD:472250	22/87 (25%)
		Ig strand B	781..785	CDD:409570	0/3 (0%)
		Ig strand C	794..798	CDD:409570	1/4 (25%)
		Ig strand E	816..821	CDD:409570	1/4 (25%)
		Ig strand F	831..836	CDD:409570	2/4 (50%)
		Ig strand G	844..847	CDD:409570	1/2 (50%)
		Protein Kinases, catalytic domain	927..1332	CDD:473864	135/412 (33%)
htl	NP_524394.2	Ig	101..191	CDD:472250	29/141 (21%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	2/3 (67%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	19/95 (20%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	132/409 (32%)