DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and btl

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1195	Identity:	276/1195 - (23%)
Similarity:	461/1195 - (38%)	Gaps:	384/1195 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 VIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRS 396
            |..|..:.|:.:|.:.||.|.:..       .:||...:                    .|...:
  Fly    36 VENSPRQRHLLSDMDITLQCVRPM-------AKWFYEDK--------------------FQLRAT 73

  Fly   397 TLTVLNAQPSDTGLYKCVTTDNSNQNVQR------------ATYRIKV-----LKQNESYLNVGE 444
            .|.:..||..::|.|.|:.:.|...|:..            |:: :|:     |.:::.:.....
  Fly    74 LLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASF-VKLEDAPALPESDLFFQPLN 137

  Fly   445 PSGHYNVQEYANRTIQMTAN--FEGFPTP--------SFSWFKPDGTEVRQSENNFKILSTELST 499
            .|....:.:...:|:|.||.  |:...:|        :.||...| |::.......|:....|:
  Fly   138 ESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHND-TQILGGRGRIKLKRWSLT- 200

  Fly   500 MLQVLNAQLQDSGTY--------VLRGSN--SFGVVQREYNVSVMDAPALKMS---DAYVQVGSV 551
               |...|.:|:|:|        ..:.||  ...|:.|::.|     |.||..   :..:.:|..
  Fly   201 ---VGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTV-----PMLKPGYPRNTSIALGDN 257

  Fly   552 ARLECTVRSYPPAIVTFFFRPCSLEPQ--W----------PTCSVLNQNFSLPSEQEKYQFQTR- 603
            ..:||.:..            .:|||:  |          .....|.:...||.:      .||
  Fly   258 VSIECLLED------------SALEPKITWLHKGNADNIDDLLQRLREQSQLPVD------VTRL 304

  Fly   604 -PRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTI-------- 659
             .|..:..|.|:..|  |..:.|...|||:|.:.    ||:..::|.|.:.|:..|:
  Fly   305 ITRMDEPQVLRLGNV--LMEDGGWYICIAENQVG----RTVAASYVDLYSPSDTTTVRTTTTTTV 363

  Fly   660 --------YGFDKDHKI----------------AKE----------DNVNFTCEALAYHFDGNLK 690
                    .|.|.|..:                .||          :.||..|..   :...|:.
  Fly   364 ASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPV---YGKANIT 425

  Fly   691 WFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYH-------------NDKD 742
            |..:.:.|.....|:::.:.       |:.....:..|.|.|.|:..:             ||:
  Fly   426 WTKDKKPLNRELGVYVQKNW-------TLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDR- 482

  Fly   743 AVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFK-------- 799
                :|...:.|    .||        :..:  |::.:|.::|...:.....|.|.:
  Fly   483 ----TRSAPIIV----VPQ--------NQTV--KVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL 529

  Fly   800 DD-KEVTESKLRHIIEKESKLL-ITHLYPGDEGVYKCVVENRLDRIERS-FTVVISDLP------ 855
            |. |.|....|...:..:|.:| :.::....||.|.|:..:.|.|...| :..|:|.||
  Fly   530 DGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYA 594

  Fly   856 -------GISMAWVWFGVILFLILIGLCVFLAVRYQKEH-------------KRHLALKAAGLAN 900
                   |.::|.:.. |.|||:......|:..|.::|.             |:.:..:..|
  Fly   595 LLHAHPLGFTLAAITI-VALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGG--- 655

  Fly   901 FEEG---AVGHIN-PDLTLDEQAELL-------------------PYNREFEFPRENLKLGKQLG 942
             |||   :.|.:. |.:.:::|...:                   |.:..:|.||:.|.||..||
  Fly   656 -EEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILG 719

  Fly   943 AGAFGVVLKGEAKGIRR--EEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGA 1005
            .||||.|:..||:|:.|  :...|.|||||||....:..:.:||.|:::|..:|:|:|::||||.
  Fly   720 EGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGC 784

  Fly  1006 VTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNG 1070
            .::.   ..|.|||||...||:::||.:||
  Fly   785 CSQG---GPLWVIVEYAPHGNLKDFLKQNR----------------------------------- 811

  Fly  1071 GGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATV 1135
                                     |...:|.||:|                 .|
  Fly   812 -------------------------PGAPQRRSDSD-----------------GY---------- 824

  Fly  1136 MTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAA 1200
                .:|..::|...:...                  :|..:|||:||||:||:|::.:|.||||
  Fly   825 ----LDDKPLISTQHLGEK------------------ELTKFAFQIARGMEYLASRRCIHRDLAA 867

  Fly  1201 RNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLW 1265
            ||:|:.:..|:||.||||||.:...:.|:|:.||:|||||:|.|||.:..:.:.|||||||::||
  Fly   868 RNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLW 932

  Fly  1266 EMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFA 1330
            |:.:....|||.|...:||::.|..|.|||||...:..:|.:|.:||.....:||.||||.:.|.
  Fly   933 EIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFD 997

  Fly  1331 NMLGEDVASH----YLDLNNPYMQS 1351
            .:| :..:|:    ||||:.|.:::
  Fly   998 GIL-QQASSNPNDAYLDLSMPMLET 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	15/97 (15%)
		Ig	<363..432	CDD:299845	12/80 (15%)
		Ig	466..533	CDD:299845	17/84 (20%)
		IG_like	672..754	CDD:214653	15/94 (16%)
		Ig	674..739	CDD:143165	12/77 (16%)
		IGc2	779..840	CDD:197706	14/70 (20%)
		PKc_like	927..1332	CDD:304357	131/406 (32%)
		Pkinase_Tyr	935..1329	CDD:285015	127/395 (32%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	19/87 (22%)
		IGc2	157..215	CDD:197706	13/62 (21%)
		IG	247..336	CDD:214652	22/108 (20%)
		Ig	258..340	CDD:143165	23/105 (22%)
		I-set	394..479	CDD:254352	14/94 (15%)
		IGc2	408..469	CDD:197706	12/70 (17%)
		IG_like	492..583	CDD:214653	20/100 (20%)
		Ig	507..583	CDD:299845	16/75 (21%)
		PKc_like	700..1000	CDD:304357	132/411 (32%)
		TyrKc	712..996	CDD:197581	127/395 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840