DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Tie

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	1367	Identity:	272/1367 - (19%)
Similarity:	433/1367 - (31%)	Gaps:	492/1367 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 EEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRE 301
            :::...::::..||..|   .::.|....::||..|...:..|....|..|...|...:....||
  Fly   115 QQQQLQLQLQLNATAGD---GESRNSAEIFSPGDVDVVGDKPTTYRPSGANRPSIAPLNSAQDRE 176

  Fly   302 R-------ARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVES 359
            |       |||:.........    |.|..|:....|                      ||.|||
  Fly   177 RKLMNVLAARRTALHRGGFRT----RIGTTGRTAISP----------------------SAAVES 215

  Fly   360 VYGMEWFTPSRDENRIFASQSRTDPKT---RNSTHQ-TGRSTLTVLN--------AQPSDTGLYK 412
                             .|::.:||::   ||.|.. |.|:|.:.:.        |.||
  Fly   216 -----------------TSKAPSDPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMPS------ 257

  Fly   413 CVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEY----------------ANRTIQM 461
                 |.|.:|        |||.:.| |....|:|..:..|.                .|.|:..
  Fly   258 -----NGNSSV--------VLKGSAS-LKAAAPAGDRDTNEILFSDESSHGLFVVAKEQNGTLNH 308

  Fly   462 TAN-------FEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGS 519
            .|:       .:|.|:.:.|.    ..:|.:.|:..|                     .||.
  Fly   309 IADGTKPAVMGKGIPSKTNSM----EDDVEEEEDELK---------------------PYVY--- 345

  Fly   520 NSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTV-RSYPPAIVTFFFRPCSLEPQWPTCS 583
              ||..........:...|.:..|.:.:|     ||.:| :|..|.|.|....|..:....||.|
  Fly   346 --FGAKLPPIRPGGLTIKAAEGDDDHPRV-----LEVSVAQSTTPTITTTSTTPAPVSSTRPTAS 403

  Fly   584 VLNQNFSLPSEQEKYQFQTRPR------------PGKLSVERI-YEVSFLPT------------- 622
            .......:...:.||::..|.|            |....|.|. |..|..||
  Fly   404 TRRPLTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDSIQDLKQT 468

  Fly   623 ----------------EPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKE 671
                            .|...|.:...::..:|..|:.:...|..:.|...|    .......|.
  Fly   469 ESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTT----STTTTTEKP 529

  Fly   672 DNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITT-----------IS 725
            .....|............|.......|..:::....||.|..|..:|...:|           |.
  Fly   530 STTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSII 594

  Fly   726 DRDR------GTYECRAYHNDKDA----VYSSREIDLYV--HDPSAPQWTNGGQEGHSKIKR--- 775
            ::|:      |....|..:.| ||    |:.:...|..|  ...:.|..|.   :...||.|
  Fly   595 EKDKELIRALGPALTREINID-DANNLIVFCNNTSDCGVTPRTQTQPSHTT---DSSPKILRTTV 655

  Fly   776 ----------KLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEG 830
                      :.:.|......:|..|.|:.   ....||...    |:|..|.     ..|.|
  Fly   656 LTSIRSTVHPRPTSTSTTTSTTTTAPPAVT---APSNEVYIG----IVESSSS-----ASPAD-- 706

  Fly   831 VYKCVVENRLD-----RIERSFTVVISDLPGISMAWVWFGVILFLI-------------LIGLCV 877
            :...|:.|..|     |.....|:|:..:..|.:|    .:||:|:             :..:|:
  Fly   707 ISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLA----AIILYLVRNFVIRRRAKQSEVFDVCI 767

  Fly   878 F----------LAVRYQ----------------------KEHKRHLALKAAGLANFEEGAVGHIN 910
            .          :..:||                      :.|:.|...:|..::...:....| |
  Fly   768 TDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANH-N 831

  Fly   911 PDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRRE-EPTTTVAVKMVKAT 974
            .....|::..|.....:||  |.|::|...||.|.||.|.|.||..:... ..|..||||.::|.
  Fly   832 RYGNNDDKTSLASEFHDFE--RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRAC 894

  Fly   975 ADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFI 1039
            :...   :|..|..||..||.|.|||.||||.   :.....|:|:||...|.:.:.|
  Fly   895 SAQV---SLKDEANIMRKLGSHQNVVTLLGAC---VESEPHMLIMEYAMRGRLLSLL-------- 945

  Fly  1040 NQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSD 1104

  Fly   946 ----------------------------------------------------------------- 945

  Fly  1105 NDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTV 1169
                   ||.|:.:.              .:..:||      ...|:.|               :
  Fly   946 -------RAARSATN--------------ILPASVP------GGRSLAP---------------L 968

  Fly  1170 TTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGL---------------- 1218
            :...|..:|..:|.||:|::.::::|.||||||:||..:.:.||||||:
  Fly   969 SPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKN 1033

  Fly  1219 -ARSMYR----------GDNY--------------------------KKSENG--------KLPI 1238
             |..:.|          |..|                          |||.:|        .|||
  Fly  1034 AANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPI 1098

  Fly  1239 KWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQE 1303
            :|:|.|||..|:|:|.:|:|::||||||:.:|...||..: ..:|:..::..|.|.:.||.:..|
  Fly  1099 RWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRHE 1162

  Fly  1304 LYEIMLECWRKNPESRPLFA----ELEKRFANMLGED-VASHYLDLN--NPYMQSNIEYMKKQST 1361
            .|.:|..||.|.|..||.||    |:.:.....:.:| .||.|:|::  :..::..:.|...:.:
  Fly  1163 FYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNHRIS 1227

  Fly  1362 DY 1363
            ::
  Fly  1228 EF 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	20/97 (21%)
		Ig	<363..432	CDD:299845	15/80 (19%)
		Ig	466..533	CDD:299845	10/66 (15%)
		IG_like	672..754	CDD:214653	18/102 (18%)
		Ig	674..739	CDD:143165	13/81 (16%)
		IGc2	779..840	CDD:197706	13/60 (22%)
		PKc_like	927..1332	CDD:304357	115/470 (24%)
		Pkinase_Tyr	935..1329	CDD:285015	111/459 (24%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	109/450 (24%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	109/448 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840