DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and KIT

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001372213.1	Gene:	KIT / 3815	HGNCID:	6342	Length:	977	Species:	Homo sapiens

Alignment Length:	1374	Identity:	315/1374 - (22%)
Similarity:	489/1374 - (35%)	Gaps:	478/1374 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEP 73
            |..|||:||:....:.|  ..||          ||...|.:.|.||.:|:.......|.|.|...
Human    11 LCVLLLLLRVQTGSSQP--SVSP----------GEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGF 63

  Fly    74 MSWW---------TSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAK 129
            :.|.         ..|::::..|:                    .|.....|.|  |:|
Human    64 VKWTFEILDETNENKQNEWITEKA--------------------EATNTGKYTC--TNK------ 100

  Fly   130 EEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYTDVVIPCKPAMPD-TEVLLETS 193
                         .|.::||||:|.|| .||......:..::..|.::.|....|: |...|:..
Human   101 -------------HGLSNSIYVFVRDP-AKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGC 151

  Fly   194 NGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPH---NEEEMTSIEVRFIATGLDIP 255
            .|:..........||:.|  |.|:|:.......|.      |   ::|..:.:..:||.
Human   152 QGKPLPKDLRFIPDPKAG--IMIKSVKRAYHRLCL------HCSVDQEGKSVLSEKFIL------ 202

  Fly   256 RTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPR 320
               .....:...|        |::|:..|    .|:|.|:
Human   203 ---KVRPAFKAVP--------VVSVSKAS----YLLREGE------------------------- 227

  Fly   321 PGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPK 385
                                     .||:.|.......|||. .|    :.||   :.|::...|
Human   228 -------------------------EFTVTCTIKDVSSSVYS-TW----KREN---SQQTKLQEK 259

  Fly   386 TRNSTHQ-----TGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEP 445
             .||.|.     ..::|||:.:|:.:|:|::.|..  |:.......|..::|:  ::.::|:
Human   260 -YNSWHHGDFNYERQATLTISSARVNDSGVFMCYA--NNTFGSANVTTTLEVV--DKGFINI--- 316

  Fly   446 SGHYNVQEYAN--RTIQMTANFEGFPTPSF-SW------FKPDGTEVRQSEN--NFKILSTELST 499
            ....|...:.|  ..:.:...:|.||.|.. .|      |.....:..:|||  |.:.:|.
Human   317 FPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSE---- 377

  Fly   500 MLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPA 564
             |.:...:..:.|||....|||.......:||.|...|.:...|..|.    ..|:|....:|..
Human   378 -LHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVN----GMLQCVAAGFPEP 437

  Fly   565 IVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTC 629
            .:.::|.|                                     ..|:....|.||.:.
Human   438 TIDWYFCP-------------------------------------GTEQRCSASVLPVDV----- 460

  Fly   630 IAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFIN 694
                       :||..:....|               |:..:.:
Human   461 -----------QTLNSSGPPFG---------------KLVVQSS--------------------- 478

  Fly   695 GEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSA 759
                       |::|..|::               ||.||:|| ||             |...||
Human   479 -----------IDSSAFKHN---------------GTVECKAY-ND-------------VGKTSA 503

  Fly   760 PQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHL 824
              :.|...:|::|                                 |....|       .|.|.|
Human   504 --YFNFAFKGNNK---------------------------------EQIHPH-------TLFTPL 526

  Fly   825 YPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKR 889
            ..|                   |.:|.             |::..:::|     |..:|.::...
Human   527 LIG-------------------FVIVA-------------GMMCIIVMI-----LTYKYLQKPMY 554

  Fly   890 HLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEA 954
            .:..|          .|..||.:..:......|||:.::||||..|..||.|||||||.|::..|
Human   555 EVQWK----------VVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATA 609

  Fly   955 KGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIV 1019
            .|:.:.:...||||||:|.:|......||:||||::.:||.|:|:||||||.|   .....:||.
Human   610 YGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT---IGGPTLVIT 671

  Fly  1020 EYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRM-------SDNYELHRDTNGGGLKYAN 1077
            |||.:|::.|||.|.|..||  .:...||.:.::....:       ||:...:.|...|
Human   672 EYCCYGDLLNFLRRKRDSFI--CSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPG------ 728

  Fly  1078 VGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPED 1142
                 .||:         .||..     |.|...|.|         || .:.|....:|    ||
Human   729 -----VSYV---------VPTKA-----DKRRSVRIG---------SY-IERDVTPAIM----ED 760

  Fly  1143 DQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCE 1207
            |:                      :.:...||:|:::|||:||.:|:||..:|.|||||||||..
Human   761 DE----------------------LALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 803

  Fly  1208 DNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAK 1272
            ..:.|||||||||.:....||....|.:||:||:|.||:.:.|::..||||||||.|||:|||..
Human   804 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGS 868

  Fly  1273 VPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV 1337
            .||||:..:.:.:..:.:|:||..|:.|..|:|:||..||..:|..||.|.::.:.....:.|..
Human   869 SPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 933

  Fly  1338 ASHYLDLNN 1346
            ...|.:|.|
Human   934 NHIYSNLAN 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	23/90 (26%)
		Ig	<363..432	CDD:299845	17/73 (23%)
		Ig	466..533	CDD:299845	20/75 (27%)
		IG_like	672..754	CDD:214653	11/81 (14%)
		Ig	674..739	CDD:143165	9/64 (14%)
		IGc2	779..840	CDD:197706	6/60 (10%)
		PKc_like	927..1332	CDD:304357	150/411 (36%)
		Pkinase_Tyr	935..1329	CDD:285015	146/400 (37%)
KIT	NP_001372213.1	Ig strand A	212..215	CDD:409353	2/10 (20%)
		ig	216..306	CDD:395002	28/154 (18%)
		Ig strand B	229..239	CDD:409353	3/9 (33%)
		Ig strand C'	250..252	CDD:409353	1/4 (25%)
		Ig strand D	260..263	CDD:409353	1/2 (50%)
		Ig strand E	267..280	CDD:409353	3/12 (25%)
		Ig strand F	287..294	CDD:409353	2/8 (25%)
		Ig strand G	300..308	CDD:409353	1/7 (14%)
		IgI_4_SCFR	312..412	CDD:409446	24/107 (22%)
		Ig strand B	332..336	CDD:409446	0/3 (0%)
		Ig strand C	346..350	CDD:409446	0/3 (0%)
		Ig strand E	376..380	CDD:409446	2/8 (25%)
		Ig strand F	390..395	CDD:409446	2/4 (50%)
		Ig strand G	403..406	CDD:409446	0/2 (0%)
		Ig	427..503	CDD:409353	25/204 (12%)
		Ig strand C	438..442	CDD:409353	0/3 (0%)
		Ig strand E	471..479	CDD:409353	2/54 (4%)
		Ig strand F	489..494	CDD:409353	3/4 (75%)
		PTKc_Kit	554..929	CDD:270682	157/450 (35%)
		Important for interaction with phosphotyrosine-binding proteins	569..571		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41363
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820