DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and KDR

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1587 Identity:397/1587 - (25%)
Similarity:636/1587 - (40%) Gaps:409/1587 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTAD 111
            |.::..|..:.:.|.|:..:.|.....:.|....:|....:..:.||.....|..:|.:.:|..:
Human    32 PRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGN 96

  Fly   112 YVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLV----DSHNVV--TAR 170
            ...||.|.          ..::|          .||.|||||.|..:..:    |.|.||  |..
Human    97 DTGAYKCF----------YRETD----------LASVIYVYVQDYRSPFIASVSDQHGVVYITEN 141

  Fly   171 QYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGR--YDPQRGFTIEIRSIVDGGDYYCRPNPPF 233
            :...|||||..::.:..|.|.....|........|  :|.::||||....|...|..:|...   
Human   142 KNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAK--- 203

  Fly   234 PHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGV--TDGDDEVLTVTNQSTGNLALIRGGDG 296
             .|:|...||....:..|..|     .::|.:.:.|:  :.|:..||..|               
Human   204 -INDESYQSIMYIVVVVGYRI-----YDVVLSPSHGIELSVGEKLVLNCT--------------- 247

  Fly   297 TLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVY 361
                       ||                                 |:.|..:|           
Human   248 -----------AR---------------------------------TELNVGID----------- 257

  Fly   362 GMEWFTPSRDE------NRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSN 420
             ..|..||...      ||...:||.::.|       ...||||:.....||.|||.|..:..  
Human   258 -FNWEYPSSKHQHKKLVNRDLKTQSGSEMK-------KFLSTLTIDGVTRSDQGLYTCAASSG-- 312

  Fly   421 QNVQRATYRIKVLKQNESYLNVGEP------SGHYN-VQEYANRTIQMTANFEGFPTPSFSWFKP 478
                      .:.|:|.:::.|.|.      ||..: |:......:::.|.:.|:|.|...|:| 
Human   313 ----------LMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYK- 366

  Fly   479 DGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVM--------D 535
            :|..:   |:|..|.:..:.|:::|..   :|:|.|.:..:|.....::.:.||::        :
Human   367 NGIPL---ESNHTIKAGHVLTIMEVSE---RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGE 425

  Fly   536 APALKMSDAYVQVGSVARLECTVRSYPPAIVTFFF----RPCSLEPQWPTCSVLNQNFSLPSEQ- 595
            ...:...|:| |.|:...|.|||.:.||.....::    ..|:.||. ...||.|   ..|.|: 
Human   426 KSLISPVDSY-QYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPS-QAVSVTN---PYPCEEW 485

  Fly   596 ---EKYQFQTRPRPGK----LSVERIYEVSFLPTE----PGILTCIAQNIIDGKERRTLTKAHVL 649
               |.:|...:....|    |...:...||.|..:    ..:..|.|.|.:...||  :...||.
Human   486 RSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGER--VISFHVT 548

  Fly   650 LGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHI-------- 706
            .|   ..:|:   ..|.:..::::|:..|.|....|: ||.|:..|   .:...:|:        
Human   549 RG---PEITL---QPDMQPTEQESVSLWCTADRSTFE-NLTWYKLG---PQPLPIHVGELPTPVC 603

  Fly   707 ETSHTKYSYKSTVHITTISD-----------RDRGTYECRAYHNDKDAVYSSREI---DLYVHDP 757
            :...|.:...:|:...:.:|           :|:|.|.|.|    :|.....|..   .|.|.:.
Human   604 KNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLA----QDRKTKKRHCVVRQLTVLER 664

  Fly   758 SAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLIT 822
            .||..| |..|..:   ..:.:::|:.|.::..|...:.||||::.:.|.....:.:....|.|.
Human   665 VAPTIT-GNLENQT---TSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIR 725

  Fly   823 HLYPGDEGVYKC---------------VVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLIL 872
            .:...|||:|.|               ::|...::......:::    |.::..::|.::|.:||
Human   726 RVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILV----GTAVIAMFFWLLLVIIL 786

  Fly   873 IGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHI----NPD-LTLDEQAELLPYN-REFEFP 931
                        :..||         ||..|...|::    :|| |.|||..|.|||: .::|||
Human   787 ------------RTVKR---------ANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFP 830

  Fly   932 RENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQH 996
            |:.|||||.||.||||.|::.:|.||.:.....||||||:|..|.:...|||:|||||::|:|.|
Human   831 RDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHH 895

  Fly   997 LNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDN 1061
            |||||||||.||  ....||||||:|:|||:..:|...|..|:                      
Human   896 LNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRSKRNEFV---------------------- 936

  Fly  1062 YELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYD 1126
                        .|...|                             :..|.|:...|.......
Human   937 ------------PYKTKG-----------------------------ARFRQGKDYVGAIPVDLK 960

  Fly  1127 RQMDTCATVMTTVPE---DDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYL 1188
            |::|:..:..::...   :::.:|:...:.|....||.      .:|...||.::||||:||::|
Human   961 RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKD------FLTLEHLICYSFQVAKGMEFL 1019

  Fly  1189 SSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFST 1253
            :|:|.:|.|||||||||.|.||||||||||||.:|:..:|.:..:.:||:||:|.|::.|.|::.
Human  1020 ASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTI 1084

  Fly  1254 YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPES 1318
            .|||||:|::|||:|||...||||:..::|...:|.:|.||..|.:...|:|:.||:||...|..
Human  1085 QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQ 1149

  Fly  1319 RPLFAELEKRFANML-------GEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSP----DE 1372
            ||.|:||.:...|:|       |:|    |:.|  |..    |.:..:....|:|..||    :|
Human  1150 RPTFSELVEHLGNLLQANAQQDGKD----YIVL--PIS----ETLSMEEDSGLSLPTSPVSCMEE 1204

  Fly  1373 LAPAAPRY---------------------VNGHIVPDIRIEE-----LPDDYMEMSRDSDPDACT 1411
            .....|::                     |:.....||.:||     :|||     ..:|.....
Human  1205 EEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDD-----NQTDSGMVL 1264

  Fly  1412 AIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPT--VDVADQAP 1474
            |......||..:...|.|.        |...|.:..:..:.||::....::|..:  .|....:.
Human  1265 ASEELKTLEDRTKLSPSFG--------GMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSS 1321

  Fly  1475 EEIPML-------HRSSTGSDGSPEQG 1494
            ||..:|       ...||.....|:.|
Human  1322 EEAELLKLIEIGVQTGSTAQILQPDSG 1348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 20/91 (22%)
Ig <363..432 CDD:299845 18/74 (24%)
Ig 466..533 CDD:299845 16/66 (24%)
IG_like 672..754 CDD:214653 20/103 (19%)
Ig 674..739 CDD:143165 17/83 (20%)
IGc2 779..840 CDD:197706 16/75 (21%)
PKc_like 927..1332 CDD:304357 152/407 (37%)
Pkinase_Tyr 935..1329 CDD:285015 148/396 (37%)
KDRNP_002244.1 Ig 41..109 CDD:299845 13/77 (17%)
IG_like 231..324 CDD:214653 30/182 (16%)
Ig1_VEGFR 239..326 CDD:143270 30/176 (17%)
IG_like 340..417 CDD:214653 19/83 (23%)
Ig2_VEGFR-2 348..417 CDD:143272 18/75 (24%)
Ig_2 551..661 CDD:290606 22/120 (18%)
IG 565..661 CDD:214652 20/103 (19%)
I-set 667..754 CDD:254352 19/90 (21%)
IGc2 680..744 CDD:197706 15/63 (24%)
PTKc_VEGFR2 826..1167 CDD:270681 154/411 (37%)
Pkinase_Tyr 834..1160 CDD:285015 148/396 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 8/51 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 310 1.000 Domainoid score I1325
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 413 1.000 Inparanoid score I1854
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 1 1.000 - - FOG0001573
OrthoInspector 1 1.000 - - otm41363
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X787
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.830

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