DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Nrk

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	167/770 - (21%)
Similarity:	262/770 - (34%)	Gaps:	285/770 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 IIDGKERRTL---TKAHVLLGNISE-----------NMTIYGFDKDHKIAKEDNVNFTCEALAYH 684
            :|:.|:.|.:   ::.|..|.|.|.           |.:..|..:    .||..|::.|.
  Fly   165 LIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTE----LKESEVSYDCR----- 220

  Fly   685 FDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSRE 749
             :||.::::...::.:| .:..:...|:|.:|.............|...||
  Fly   221 -NGNGRFYMGTMNVSKS-GIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCR-------------- 269

  Fly   750 IDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIE 814
                         ..||:|.|     ....|::          ..|||...|
  Fly   270 -------------NAGGEEPH-----PWCYTVD----------ESVRWQHCD------------- 293

  Fly   815 KESKLLITHLYPGDEGVYKC---VVENRLD-----RIERSFTVVISDLPGISMAWVWFGV-ILFL 870
                            :..|   |..|.:|     ::|:.||.        ||.::..|: .:.:
  Fly   294 ----------------IPMCPDYVDPNAVDLNTPIKMEKFFTP--------SMIFLLAGIGFVAI 334

  Fly   871 ILIGLCVFLAVRYQKEHKRHLALKAAGLANFE------------------------EGAV----- 906
            :.:.|.:.|..:..| ||.:  .:.||.|..|                        .|..
  Fly   335 VTLHLMILLVYKLSK-HKDY--SQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAK 396

  Fly   907 -GHINPDLTLDEQAELL-------------PYNR--EFEFPRENLKLGKQLGAGAFGVVLKGEAK 955
             |.|....|:......|             |..|  :.|:||.::...:.||.||||.|.:..|.
  Fly   397 WGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAP 461

  Fly   956 GIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVE 1020
            |:..::....|||||:|..|.:::......|..::... .|.|:|.|||.....   |.:.::.|
  Fly   462 GLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEF-DHPNIVRLLGVCALG---RPMCLLFE 522

  Fly  1021 YCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSY 1085
            |...|::..||   |.|     :|                              ||
  Fly   523 YMAPGDLSEFL---RAC-----SP------------------------------YA--------- 540

  Fly  1086 INEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNS 1150
                        ||:                                      .|..|::..|.
  Fly   541 ------------THQ--------------------------------------APTQDRLQLNE- 554

  Fly  1151 VQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICD 1215
                                 :.|:..|..:|.||.|||.:|.:|.|||.||.|:.|...|||.|
  Fly   555 ---------------------LHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIAD 598

  Fly  1216 FGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDP 1280
            |||:..:|..|.||..||..:||:|:.|||:..:.||..||||:|||.|||:||.|..||.|: .
  Fly   599 FGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGL-T 662

  Fly  1281 NQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGE 1335
            ::|:...:.:|..:..|......:|.:|..||.:.|..||.|||:.....:.:.|
  Fly   663 HEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAE 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	11/81 (14%)
		Ig	674..739	CDD:143165	11/64 (17%)
		IGc2	779..840	CDD:197706	8/63 (13%)
		PKc_like	927..1332	CDD:304357	109/404 (27%)
		Pkinase_Tyr	935..1329	CDD:285015	106/393 (27%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	9/50 (18%)
		KR	217..299	CDD:214527	20/159 (13%)
		PTKc_Musk	435..713	CDD:133181	109/401 (27%)
		Pkinase_Tyr	441..707	CDD:285015	105/389 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940