DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_954545.1	Gene:	Fgfrl1 / 360903	RGDID:	735156	Length:	529	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	115/603 - (19%)
Similarity:	189/603 - (31%)	Gaps:	238/603 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 RTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNS 521
            ||:::....||.|.|...|.| ||..:....:.|::|...    |:|...:.:|:|.||.:.:|.
  Rat    41 RTVRLQCPVEGDPPPLTMWTK-DGRTIHSGWSRFRVLPQG----LKVKEVEAEDAGVYVCKATNG 100

  Fly   522 FGVVQREYNVSVMD---------APALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEP 577
            ||.:...|.:.:||         .|.          ||....|..|                 ..
  Rat   101 FGSLSVNYTLIIMDDISPGKENPGPG----------GSSGGQEDPV-----------------SQ 138

  Fly   578 QWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQ-----NIIDG 637
            ||     ....|:.||:..:   :...||...||.              |.|:|.     :|:..
  Rat   139 QW-----ARPRFTQPSKMRR---RVIARPVGSSVR--------------LKCVASGHPRPDIMWM 181

  Fly   638 KERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESD 702
            |:.:|||:...               .:|:                    ..||.::.::||..|
  Rat   182 KDDQTLTRLEA---------------SEHR--------------------KKKWTLSLKNLKPED 211

  Fly   703 SVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTN--- 764
            |                          |.|.||. .|...|:.::.::|:.....|.|..|.
  Rat   212 S--------------------------GKYTCRV-SNRAGAINATYKVDVIQRTRSKPVLTGTHP 249

  Fly   765 -------GGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKE------ 816
                   ||             |...:|...:....:::|.|..:..:|.:....|:..
  Rat   250 VNTTVDFGG-------------TTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVV 301

  Fly   817 ---------------SKLLITHLYPGDEGVYKCVVENRLDRIERS-FTVVISD--LPG------- 856
                           :||||:.....|.|:|.|:..|.:....|| |..|:.|  .||
  Rat   302 LPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVAHSS 366

  Fly   857 --ISMAW-VWFGV------ILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPD 912
              .|:.| |..|:      ||..:|:.||         :.|:.....|:.|.     ..||..|.
  Rat   367 STTSLPWPVVIGIPAGAVFILGTVLLWLC---------QTKKKPCAPASTLP-----VPGHRPPG 417

  Fly   913 LTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKA---T 974
            .:.:...:                  |.|.:.|.|:.          ||..:|:|.:.:.|   |
  Rat   418 TSRERSGD------------------KDLPSLAVGIC----------EEHGSTMAPQHILAPGST 454

  Fly   975 ADNEVVRALVSELKIMVH 992
            |..::...|.:::....|
  Rat   455 AGPKLYPKLYTDVHTHTH 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	20/66 (30%)
		IG_like	672..754	CDD:214653	13/81 (16%)
		Ig	674..739	CDD:143165	10/64 (16%)
		IGc2	779..840	CDD:197706	15/81 (19%)
		PKc_like	927..1332	CDD:304357	13/69 (19%)
		Pkinase_Tyr	935..1329	CDD:285015	13/61 (21%)
Fgfrl1	NP_954545.1	I-set	29..112	CDD:400151	22/75 (29%)
		Ig strand A'	35..38	CDD:409353
		Ig strand B	41..50	CDD:409353	2/8 (25%)
		Ig strand C	56..61	CDD:409353	1/4 (25%)
		Ig strand C'	64..67	CDD:409353	0/2 (0%)
		Ig strand D	72..77	CDD:409353	1/4 (25%)
		Ig strand E	78..84	CDD:409353	2/9 (22%)
		Ig strand F	91..99	CDD:409353	3/7 (43%)
		Ig strand G	102..112	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..152		10/66 (15%)
		IgI_2_FGFRL1-like	143..234	CDD:409442	28/169 (17%)
		Ig strand B	164..168	CDD:409442	2/17 (12%)
		Ig strand C	177..181	CDD:409442	1/3 (33%)
		Ig strand E	200..204	CDD:409442	1/3 (33%)
		Ig strand F	214..219	CDD:409442	2/4 (50%)
		Ig strand G	227..230	CDD:409442	0/2 (0%)
		Ig	242..350	CDD:416386	22/120 (18%)
		Ig strand A	242..245	CDD:409353	1/2 (50%)
		Ig strand A'	249..253	CDD:409353	0/3 (0%)
		Ig strand B	261..268	CDD:409353	1/6 (17%)
		Ig strand C	272..279	CDD:409353	1/6 (17%)
		Ig strand D	304..309	CDD:409353	0/4 (0%)
		Ig strand E	317..322	CDD:409353	3/4 (75%)
		Ig strand F	330..338	CDD:409353	3/7 (43%)
		Ig strand G	341..349	CDD:409353	2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		5/44 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900