DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Y50D4B.6

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_503375.2	Gene:	Y50D4B.6 / 3565593	WormBaseID:	WBGene00021745	Length:	421	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	129/565 - (22%)
Similarity:	220/565 - (38%)	Gaps:	191/565 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 IERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGL--------- 898
            |:|:..|:...:..|:::.:::.|..|..|          .::||:...:|::..:
Worm     2 IDRNILVIFYCIVVIALSVLFYYVWKFYYL----------RKEEHEETRSLESGIIHSSSQKTPS 56

  Fly   899 ----------ANFEEGAVG-------HINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAF 946
                      ||.|...:|       .|..:|..||:.| :..|: |.|  .||..   ||.|.:
Worm    57 SVRENESLLQANEENVPIGLETEPINAIIKNLKFDERFE-IDVNK-FSF--YNLSF---LGNGYY 114

  Fly   947 GVVL-----KGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAV 1006
            |.|.     |.:..|:..|. :..||||......|....:.:..||.:|..:|:|.|::.|:..:
Worm   115 GKVFKERMHKKQKNGLDSEN-SLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRWI 178

  Fly  1007 TKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGG 1071
            ..|    |::::.|:...|::..:|...|:.|    |.|...::         ||..|
Worm   179 RTN----EILIVSEFVEKGDLVEYLRARRRYF----NKDIVCVE---------DNGRL------- 219

  Fly  1072 GLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVM 1136
                                                                       .|.|
Worm   220 -----------------------------------------------------------LCPT-- 223

  Fly  1137 TTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAAR 1201
                                                ||:|:|||:|.||.:|.:...:|.|||.|
Worm   224 ------------------------------------DLLSFAFQIANGMKFLGNVACVHRDLALR 252

  Fly  1202 NILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLA-----LESLSDHV-FSTYSDVWSY 1260
            |:.:..:.:::|.||||||.....:.|:|..:...|:||||     .|...::: |.:.||:|||
Worm   253 NVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSY 317

  Fly  1261 GIVLWEMFSLAKVPYPGID--PN--QELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPL 1321
            |:.|:|:|||...||.|:|  |:  |.|...:.||.::..|:..:.::||.|..||..||:.||:
Worm   318 GVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPV 382

  Fly  1322 FAELEKRFANMLGEDVASHYLDLNNPYMQS---NIEYMKKQSTDY 1363
            |:|....|..:|.:        ::.|:.::   .|:..:|..|.|
Worm   383 FSECRDFFQKLLQQ--------VSKPFFENLLKEIQNEEKLQTSY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357	103/419 (25%)
		Pkinase_Tyr	935..1329	CDD:285015	99/408 (24%)
Y50D4B.6	NP_503375.2	PTKc	109..391	CDD:270623	98/403 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820