DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and tek

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_009299388.1	Gene:	tek / 30747	ZFINID:	ZDB-GENE-990415-56	Length:	1117	Species:	Danio rerio

Alignment Length:	931	Identity:	208/931 - (22%)
Similarity:	352/931 - (37%)	Gaps:	249/931 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 NRTIQMTAN--FEGFPTP---SFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYV 515
            |..::::.|  ..|.|.|   ..:....:.|.:...:.:  .|:.:.:::.:|...::..:|.:.
Zfish   359 NTGVELSVNCSASGRPAPLHGDITLITANRTTIAAVDTH--TLNDQSTSVFRVQQVRVSSAGRWR 421

  Fly   516 LRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVAR---LECTVRSY----PPAIVTFFFRPC 573
            .:.:|:...|:.|:.|.|...|  :..:..|..||..|   |......|    |.|..|..:||.
Zfish   422 CQVNNTHAQVEDEFTVEVKVPP--RPQNPPVLQGSGPRHLLLLLNTEPYSGDGPIATTTLLYRPA 484

  Fly   574 SLEPQWPTCS----VLNQNFSLPSEQEKYQFQ-TRPRPGKLSVERIYEVSFLPTEPGILTCIAQN 633
            |.. .|.:.:    ::..:...|..|...|.| :||.||...            :.|.....:..
Zfish   485 SAH-TWSSFTAHGPLVRLDNLYPMTQYLTQVQLSRPGPGGAG------------QAGPAATFSTQ 536

  Fly   634 IIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIA-KEDNVNFTCEALAYHFDGNLKWFINGED 697
            :::       ....|.|..:|:...:..:|    || .|.:..:....|.....|.|:.|   :.
Zfish   537 VLE-------LPVGVKLSAVSQTALLLSWD----IAPAEQHCTYEVSCLQAGAPGTLRTF---QL 587

  Fly   698 LKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQW 762
            ...|.::|:.....::.|:.||..:           |....|                .|||..|
Zfish   588 PSNSSAMHLSDLKPRHKYQCTVRSS-----------CGVGQN----------------HPSASAW 625

  Fly   763 TNGGQE-----GHSKIKRKLSQTLELECA---STAVPVAIVRWFKDDKEVTESKLRHIIEKESKL 819
            |....|     .:..|......:..|..|   ..:|..|::|:    ::|.:::.|..:|...:.
Zfish   626 TLSDPELPPPPANISIWNISDTSAVLTWAVAEGESVSRAVIRF----QQVEQAQYRQQVELPVQT 686

  Fly   820 LITH-------LYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVW-------------- 863
            ...|       |.|......:....|.:.....|..|.:..||....:.::
Zfish   687 QQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQESSALFAAHGHLLLYAILGS 751

  Fly   864 FGVILFLILIGLCVFLAVRYQKEHKR-HLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNRE 927
            .|:....:|:..|:.|.::.....:| |..|:.....:|......|....:.          :|.
Zfish   752 AGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEPAVHFSSAPPPHRRSAVV----------SRS 806

  Fly   928 FEFPR---ENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKI 989
            ..||.   .:::....||.|.||.|||..   ||::......|||.:|..|..:..|....||::
Zfish   807 LVFPALQWSDIQFQDVLGEGNFGQVLKAR---IRKDGLRMDAAVKRMKDYASQDDHRDFAGELEV 868

  Fly   990 MVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIM 1054
            :..||.|.|:::||||...   :..|.:.:|:...||:.:||.::|
Zfish   869 LCRLGPHKNIIHLLGACEH---RGYLYLAIEFAPHGNLLDFLRKSR------------------- 911

  Fly  1055 TQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSG 1119

Zfish   912 ----------------------------------------------------------------- 911

  Fly  1120 TATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARG 1184
                               |.|.|         ||:...::|    |.|:::..|::::..||||
Zfish   912 -------------------VLETD---------PAFAIAHRT----ASTLSSQQLLAFSADVARG 944

  Fly  1185 MDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDH 1249
            |.|||.|:.:|.||||||:|:.|:.|.||.||||:|..   :.|.|...|:||::|:|:|||:..
Zfish   945 MSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLSRGQ---EVYVKKTMGRLPVRWMAIESLNYS 1006

  Fly  1250 VFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRK 1314
            |::|.|||||||::|||:.||...||.|: ...||:.||..|:|:|||...:.|:||:|.:|||:
Zfish  1007 VYTTNSDVWSYGVLLWEVVSLGGTPYCGM-TCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWRE 1070

  Fly  1315 NPESRPLFAELEKRFANMLGE 1335
            .|..||.|:::......||.|
Zfish  1071 KPFERPSFSQILLSLGRMLEE 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	11/69 (16%)
		IG_like	672..754	CDD:214653	11/81 (14%)
		Ig	674..739	CDD:143165	10/64 (16%)
		IGc2	779..840	CDD:197706	12/70 (17%)
		PKc_like	927..1332	CDD:304357	117/407 (29%)
		Pkinase_Tyr	935..1329	CDD:285015	115/393 (29%)
tek	XP_009299388.1	Ig_Tie2_1	25..121	CDD:287411
		EGF_2	224..255	CDD:285248
		IG_like	354..439	CDD:214653	13/81 (16%)
		fn3	541..621	CDD:278470	18/113 (16%)
		FN3	633..717	CDD:214495	13/87 (15%)
		PTKc_Tie2	809..1111	CDD:133219	120/409 (29%)
		STYKc	817..1085	CDD:214568	115/393 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810