DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and fgfr1a

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_009302578.1	Gene:	fgfr1a / 30705	ZFINID:	ZDB-GENE-980526-255	Length:	811	Species:	Danio rerio

Alignment Length:	840	Identity:	226/840 - (26%)
Similarity:	341/840 - (40%)	Gaps:	254/840 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 TRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNIS---ENMTIYGFD 663
            ||.|..::.:|::.     ||:.|:..|.||.         |...|....|||   |...:....
Zfish    77 TRLRNDQMEIEKVE-----PTDSGLYACFAQG---------LNSNHTEYFNISVTDEEDEVDSSS 127

  Fly   664 KDHKIAKEDN-------------------------VNFTCEALAYHFDGN----LKWFINGEDLK 699
            ::.|::.:.|                         |.|.|:|     :||    |||..||::.|
Zfish   128 EEAKLSNDQNLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQA-----NGNPTPTLKWLKNGKEFK 187

  Fly   700 ESDSVHIETSHTKYSYKSTVHITTI-----SDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSA 759
            ....:.        .:|...|:.||     ...|||.|.| ...|...::..:.::|:....|..
Zfish   188 RDQRIG--------GFKVREHMWTIIMESVVPSDRGNYTC-LVENRHGSINHTYQLDVVERSPHR 243

  Fly   760 PQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESK-----------LRHII 813
            |....|.....:.:   :...:|.||...:.|...::|.| ..||..|:           |::..
Zfish   244 PILQAGLPANRTAV---VGSDVEFECKVFSDPQPHIQWLK-HIEVNGSRYGPDGLPYVRALKNSG 304

  Fly   814 EKESKLLITHLYPGDE---GVYKCVVENRLDRIERS--FTVV-------ISDLPG---ISMAWVW 863
            ...|...:..||...|   |.|.|.|.|.:.:..:|  .|||       .:.||.   :.:....
Zfish   305 VNSSDTQVLTLYNVTEEQSGEYICKVSNYIGQANQSAWLTVVKHLQAVPPTQLPNQTYLEVLIYC 369

  Fly   864 FGVILFLILIGLCVF---------------LAVRYQKEHK--------RHLALKAAGLANFEEGA 905
            .|..|..:::|..|.               |||     ||        |.:.:.....::...|.
Zfish   370 VGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAV-----HKLAKSIPLRRQVTVSVDSSSSMHSGG 429

  Fly   906 VGHINPDLTLDEQAELLPYNREFEFP--------RENLKLGKQLGAGAFGVVLKGEAKGIRREEP 962
            : .:.|.......:.:|....|:|.|        |:.|.|||.||.|.||.|:..||.|:.:|:|
Zfish   430 M-LVRPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKP 493

  Fly   963 T--TTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFG 1025
            .  |.|||||:|:.|..:.:..|:||:::|..:|:|.|::|||||.|::   ..|.||||:...|
Zfish   494 NRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEFAAKG 555

  Fly  1026 NIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPH 1090
            |::.:|...|
Zfish   556 NLREYLRVRR------------------------------------------------------- 565

  Fly  1091 NNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAW 1155
                 ||                              .|:.|
Zfish   566 -----PP------------------------------GMEYC----------------------- 572

  Fly  1156 RSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLAR 1220
               |..|......::..||:|.|:||||||:||:|||.:|.||||||:|:.||||:||.||||||
Zfish   573 ---YNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR 634

  Fly  1221 SMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELF 1285
            .::..|.|||:.||:||:||:|.|:|.|.:::..|||||:|::|||:|:|...||||: |.:|||
Zfish   635 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELF 698

  Fly  1286 NKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLN 1345
            ..|.:|:||::|.....|||.:|.:||...|..||.|.:|.:.....|.......||||:
Zfish   699 KLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLDLS 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	24/115 (21%)
		Ig	674..739	CDD:143165	21/73 (29%)
		IGc2	779..840	CDD:197706	19/74 (26%)
		PKc_like	927..1332	CDD:304357	139/414 (34%)
		Pkinase_Tyr	935..1329	CDD:285015	135/395 (34%)
fgfr1a	XP_009302578.1	Ig	28..116	CDD:416386	14/52 (27%)
		Ig strand A	28..31	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	47..57	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..71	CDD:409353
		Ig strand D	76..80	CDD:409353	2/2 (100%)
		Ig strand E	83..88	CDD:409353	0/4 (0%)
		Ig strand F	94..103	CDD:409353	3/8 (38%)
		Ig strand G	106..116	CDD:409353	3/9 (33%)
		Ig	142..236	CDD:416386	22/107 (21%)
		Ig strand A	142..145	CDD:409353	0/2 (0%)
		Ig strand A'	153..158	CDD:409353	0/4 (0%)
		Ig strand B	162..170	CDD:409353	4/12 (33%)
		Ig strand C	176..181	CDD:409353	3/4 (75%)
		Ig strand C'	184..186	CDD:409353	0/1 (0%)
		Ig strand D	195..198	CDD:409353	1/2 (50%)
		Ig strand E	202..207	CDD:409353	2/4 (50%)
		Ig strand F	216..223	CDD:409353	2/7 (29%)
		Ig strand G	226..236	CDD:409353	0/9 (0%)
		Ig	244..345	CDD:416386	22/104 (21%)
		Ig strand A	244..247	CDD:409353	1/2 (50%)
		Ig strand A'	251..255	CDD:409353	0/3 (0%)
		Ig strand B	263..270	CDD:409353	3/6 (50%)
		Ig strand C	274..281	CDD:409353	2/7 (29%)
		Ig strand D	296..301	CDD:409353	0/4 (0%)
		Ig strand E	311..316	CDD:409353	0/4 (0%)
		Ig strand F	324..332	CDD:409353	4/7 (57%)
		Ig strand G	335..343	CDD:409353	1/7 (14%)
		FGFR3_TM	358..387	CDD:407957	5/28 (18%)
		PTKc_FGFR1	452..753	CDD:270678	139/420 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910