DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and ret

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	1048	Identity:	252/1048 - (24%)
Similarity:	398/1048 - (37%)	Gaps:	368/1048 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 VRQSENNFKI-LSTELSTMLQ--VLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDA 544
            ||.:.:.:|: ||..||...|  .|...|.:..|:    ....|.|...:||:|:..| ::.|:
Zfish   332 VRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTF----PGPEGTVLLHFNVTVLPVP-IRFSN- 390

  Fly   545 YVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKL 609
                                 ||:                   :|::..:...|.     :.||:
Zfish   391 ---------------------VTY-------------------SFTVSQKATTYS-----QIGKV 410

  Fly   610 SVERIYEVSFLPTEPGILTCIAQNIIDGK---ERRTLTKAHVLLGNISENMTIYGFDKDHKIAKE 671
            .||...:..      ||.......|:|..   |.::...|..|..|.::|..:. :..|.|:.:.
Zfish   411 CVENCQKFK------GIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPNDNTGVL-YVNDTKVLRR 468

  Fly   672 DNVNFTCEALAY-------------------HFDGNLKWFINGEDLKESDSVHIETSHTKYSYKS 717
            ..    |:.|.|                   .|.|            |:||  ::|...::.
Zfish   469 PE----CQELEYVVIAQEQQNKLQAKTQLTVSFQG------------EADS--LKTDEPRFP--- 512

  Fly   718 TVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAP----QWTNGGQEGHSK------ 772
                .....|.||  :|.|          :|.:       .||    ||..|..:|.||
Zfish   513 ----ACAEKRQRG--DCEA----------TRGL-------GAPTGRCQWRQGRDKGISKRYSTCS 554

  Fly   773 -------------IKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHL 824
                         |:.|.......:|:|.    ||:..::.|                      |
Zfish   555 PNLGTCPDGYCDAIESKNISICPQDCSSE----AIIGGYERD----------------------L 593

  Fly   825 Y---PGDEGVY----KCVVENRLDRIERSFTVVISDLPGISMAWVWFGVIL-FLILIGLCVFLAV 881
            |   .|....|    ||..|.  |..|..   :.:|:....:|   .|:|| |::.:.|..:...
Zfish   594 YGIKAGHGTCYCFEGKCFCER--DEPEDD---ICNDMCKTVIA---TGIILSFIVSVLLSSYFIH 650

  Fly   882 RYQKEHKRHLALKAA--------------GLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPR 932
            ||.|...:.....|.              ...|....::..:...:.:|  ...:|.:.::||||
Zfish   651 RYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAID--TFKIPEDPKWEFPR 713

  Fly   933 ENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHL 997
            :||.|||.||.|.||.|:|..|..::.:...|||||||:|..|.:..:|.|:||..::..: .|.
Zfish   714 KNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQV-NHP 777

  Fly   998 NVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNY 1062
            :|:.:.||.:::   ..|.:||||.::|:::|||..:||            :.||.|....:.|
Zfish   778 HVIKMYGACSQD---GPLYLIVEYAKYGSLRNFLRESRK------------VGPSYMGNDANRN- 826

  Fly  1063 ELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDR 1127
                                .||:..|                |.|:
Zfish   827 --------------------SSYLENP----------------DERA------------------ 837

  Fly  1128 QMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKK 1192
                                                     :|..||||:|:|::|||.||:..|
Zfish   838 -----------------------------------------LTMGDLISFAWQISRGMQYLAEMK 861

  Fly  1193 VLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDV 1257
            ::|.||||||:|:.|...:||.||||:|.:|..|:|.|...|::|:||:|:|||.||:::|.|||
Zfish   862 LVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDV 926

  Fly  1258 WSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF 1322
            ||:|::|||:.:|...|||||.| :.|||.|..|||||||:....|:|.:||.||::..:.||.|
Zfish   927 WSFGVLLWEIVTLGGNPYPGIAP-ERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF 990

  Fly  1323 AELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGS--------PDELAPAAPR 1379
            :::.|                        .:|.|..:|.|||.|..|        .|.|:.....
Zfish   991 SDISK------------------------ELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTP 1031

  Fly  1380 YVNGHIVPDIRIEELPDDYME-----MSRDSDPDACTAIFSP---TRLEGESSDFPDFSSETTFN 1436
            .|:....|..|  .||..::|     ||..:.|:.     ||   .||:..:..|..:::::.:.
Zfish  1032 LVDCSNAPLPR--TLPSTWIENKLYGMSYPNWPEK-----SPVPLNRLDATNPVFTRYANDSVYA 1089

  Fly  1437 FPGARQSP 1444
            ...|..||
Zfish  1090 NWMALHSP 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	15/52 (29%)
		IG_like	672..754	CDD:214653	15/100 (15%)
		Ig	674..739	CDD:143165	14/83 (17%)
		IGc2	779..840	CDD:197706	12/67 (18%)
		PKc_like	927..1332	CDD:304357	135/404 (33%)
		Pkinase_Tyr	935..1329	CDD:285015	130/393 (33%)
ret	NP_858048.2	CA	186..256	CDD:214520
		PTKc_RET	715..1004	CDD:173631	133/425 (31%)
		Pkinase_Tyr	716..997	CDD:285015	130/417 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810