DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and kita

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	1176	Identity:	305/1176 - (25%)
Similarity:	479/1176 - (40%)	Gaps:	335/1176 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 LAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENR 374
            :.|..:.|:..|  :|..|..|:.           :||:|.|:.::.|      .|    :.|||
Zfish    16 IQPGRSRPTITP--EGPRLTVPLY-----------SNFSLHCQSNSTV------RW----QHENR 57

  Fly   375 IFASQSRTDPKTRNSTHQTGRSTLTVLN-AQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNES 438
                    ..:|.....:.|:.|:..:| |.|...|.|.|    ...:..::::..:.|    ::
Zfish    58 --------PMRTLKEEQRQGQQTILKVNRAGPQHLGKYSC----REEKTGEKSSIYVYV----KA 106

  Fly   439 YLNVGEPSGHYNVQEYANRTIQM-TANFEGFPT-----------PSFSWFKPDGTEVRQSENNFK 491
            :|: .:|...:      .|||.. ....||..|           .:.:..|.||    |...|..
Zfish   107 FLS-ADPENPF------RRTIVFDIVAAEGDTTVIPCLATDPDMKNLNLQKCDG----QPLPNSL 160

  Fly   492 ILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLEC 556
            ..|..|.|.:.|...:.:..|.||.              |..:||..:|.          .|.:.
Zfish   161 RYSASLETGVSVEKVRKEFEGCYVC--------------VGTLDAATVKS----------GRYQL 201

  Fly   557 TVRSYPPAIVTFFFRPCSL-EPQWP----------TCSVLNQNFSL-----------PSEQEKYQ 599
            |||..|.|.     .|.:| :||..          :||..|.|..:           ||..:...
Zfish   202 TVRLVPDAP-----PPITLGQPQRVLLTQGEKLSLSCSTSNVNSDIAVKWKAPNGVNPSVHQNSH 261

  Fly   600 FQTRP----RPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIY 660
            ..|.|    |...||:.     |....:.|..:|.|.|     |:.|..|.  :..||.|.
Zfish   262 LLTEPITHVRTAILSLS-----SVTMQDAGNYSCEAIN-----EKGTTAKP--VWVNIYEK---- 310

  Fly   661 GF-------DKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTK-YSYKS 717
            ||       :...::...::::......||.......|..:|..|..:.. |:.||.|. .||.|
Zfish   311 GFINITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSWSYSGVKLTNTTD-HVITSRTHGNSYTS 374

  Fly   718 TVHITTISDRDRG--TYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTN--GGQEGHSKIKRKLS 778
            .:.:..:...:.|  |:.|.    ::||....   ...||..|.||..:  |..:|
Zfish   375 ELKLVRLKVSESGIYTFSCL----NRDATIRQ---TFEVHVISKPQIVSYEGPIDG--------- 423

  Fly   779 QTLELECASTAVPVAIVRWFKDDKEVTESKLRHII----EKESKLLITHLYP--GDEGVYKCVVE 837
               ::.|.:...|...::|:..|  :..|:..:::    |:|..:.:|...|  |     |..||
Zfish   424 ---QVRCVAEGYPTPQIKWYYCD--LPHSRCSNLLNATQEEEDVVTVTMTNPPFG-----KGAVE 478

  Fly   838 NRLDRIERSFTV----------VISDLPGIS-------------MAWVWFGVILFLILIGLCVFL 879
            :||:..:.::..          ::..|..||             :.:|...|||.||||    .|
Zfish   479 SRLNITKNNYATLECVASANGEIVYTLFSISENTVPHELFTPLLIGFVAAAVILVLILI----VL 539

  Fly   880 AVRYQKEHKRHLALKAAGLANFEEGAVG----HINPDLTLDEQAELLPYNREFEFPRENLKLGKQ 940
            ..:|.::.|..:..|..      ||..|    :|:|        ..|||:.::||||:.|:.||.
Zfish   540 TYKYMQKPKYQIQWKVI------EGIHGNNYVYIDP--------TQLPYDHQWEFPRDKLRFGKT 590

  Fly   941 LGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGA 1005
            ||:||||.|::..|.|:.:.:...||||||:|.:|......||:||||::.:||.|:|:||||||
Zfish   591 LGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATEKEALMSELKVLSYLGNHINIVNLLGA 655

  Fly  1006 VTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNG 1070
            .|   .....:||.|||.||::.|||.|.|..|                          :..|.|
Zfish   656 CT---VGGPTLVITEYCCFGDLLNFLRRRRVYF--------------------------YYTTLG 691

  Fly  1071 GGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATV 1135
            ....|.||...     :||               ||.|:|                        .
Zfish   692 EDAYYRNVMMQ-----SEP---------------NDSRNG------------------------Y 712

  Fly  1136 MTTVPEDDQIMSNNSVQPAWRSNYKTDS--------TEAMTVTTVDLISWAFQVARGMDYLSSKK 1192
            ||..|....|:|:.:.:...:.:..:||        .:.:|:.|.||:|:::|||:|||:|:||.
Zfish   713 MTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMDFLASKN 777

  Fly  1193 VLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDV 1257
            .:|.|||||||||.:..|.|||||||||.:....||....|.:||:||::.||:.:.|::..|||
Zfish   778 CIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSPESIFECVYTFESDV 842

  Fly  1258 WSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF 1322
            |||||:|||:|||...||||:..:.:.:..:.:|||||.|:|:..|:|:||..||..:|..||.|
Zfish   843 WSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSF 907

  Fly  1323 AELEKRFANMLG---------------------EDVASHYLDLNN---------PYMQSNIEYMK 1357
            :::.::....:.                     |:.:||...||:         |.:.||..::.
Zfish   908 SKIVEKIEQQISDSTKHIYLNFSSRLPAAPGPREESSSHVHRLNSVGSHSTATQPLLSSNDVFLD 972

  Fly  1358 KQSTDY 1363
            :.|..:
Zfish   973 RSSPSH 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	18/86 (21%)
		Ig	<363..432	CDD:299845	13/69 (19%)
		Ig	466..533	CDD:299845	16/77 (21%)
		IG_like	672..754	CDD:214653	17/84 (20%)
		Ig	674..739	CDD:143165	15/67 (22%)
		IGc2	779..840	CDD:197706	13/66 (20%)
		PKc_like	927..1332	CDD:304357	151/412 (37%)
		Pkinase_Tyr	935..1329	CDD:285015	147/401 (37%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653	20/107 (19%)
		IG_like	218..307	CDD:214653	21/100 (21%)
		ig	218..297	CDD:278476	19/88 (22%)
		Ig	311..410	CDD:299845	21/106 (20%)
		IG_like	325..408	CDD:214653	18/90 (20%)
		PTKc_Kit	549..918	CDD:270682	160/455 (35%)
		Pkinase_Tyr	585..914	CDD:285015	147/401 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1456
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25366
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820