DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and flt4

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_571020.2	Gene:	flt4 / 30121	ZFINID:	ZDB-GENE-980526-326	Length:	1368	Species:	Danio rerio

Alignment Length:	1661	Identity:	400/1661 - (24%)
Similarity:	660/1661 - (39%)	Gaps:	488/1661 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDN------TEDP---------- 95
            |.:...|..::::|..:..:.|.....:.|...:.....|:..|.      |:.|
Zfish    30 PTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKEC 94

  Fly    96 ----ARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDP 156
                .:|:...|.|....|:....|.|.    :..|       :|:|:...   |:||:|:|.||
Zfish    95 QGVAGKPYCKILILTNAQANDSGYYRCF----YKDI-------KAVIDGTT---AASIFVFVRDP 145

  Fly   157 DTKLV-----DSHNVVTARQYTDVVIPCKPAMPDTEVLL-------ETSNGEMHSSKSVGRYDPQ 209
            :...:     |...:......|.:.:||..:.||.:|.|       |..:|      ||..::.:
Zfish   146 EHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDG------SVVTWNNK 204

  Fly   210 RGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGD 274
            :|::|                   |.:..:.||..:.|..: :.:..:|.|:.:|
Zfish   205 KGWSI-------------------PRHIIQNTSTFIGFYCS-ISVQNSQHTSSIY---------- 239

  Fly   275 DEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEH 339
              |:.|.........|.                                   |...||
Zfish   240 --VVQVIGLKFYEFKLF-----------------------------------PEDSPV------- 260

  Fly   340 HVFTDTNFTLDCEQSAYVESVYGM--EWFTPSRDENRIFASQ---SRTDPKTRNSTHQTGRSTLT 399
            .:....:..|:|  :|.|:...|:  :|..|.:.|||:.:.|   :..|..|..|      |.|:
Zfish   261 ELMQGESLVLNC--TALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEIS------SILS 317

  Fly   400 VLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTAN 464
            :.|....|:|.|.|.    :|....:......|:...:.::::...:|.....:...::::::..
Zfish   318 IRNIHLDDSGYYTCW----ANTLEMKRELTTVVIVHEKPFISLDYRNGSVIEAKEGQKSVRLSVK 378

  Fly   465 FEGFPTPSFSWFKPDGTEVRQSENNFKILSTELST-------MLQVLNAQLQDSGTYVLRGSNSF 522
            ...:|:|...|:|           |.|::|::.|:       .||:.:...||:|.|:|...||.
Zfish   379 VSAYPSPEIQWYK-----------NGKLISSKNSSRFKVQQHSLQIRDVCKQDAGEYMLVLKNSP 432

  Fly   523 GVVQREYNVS-VMDAP-------ALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFR---PCSLE 576
            ..:::..|.: :::.|       |...::.|.: |:...|.||....|||.:::.:|   ||.||
Zfish   433 AALEKRLNFTLIVNVPPQIHEKEAAPPTNLYGK-GTRQILTCTADGSPPASISWQWRPWSPCDLE 496

  Fly   577 ------------PQWPTCSVLNQNFSLPSEQ-----EKYQFQTRPRPGK-LSVERIYEVSFLPTE 623
                        .|.|.|   :....|..|.     |.....|:...|| .:|.|:  |....:.
Zfish   497 RTRRALRRRGGRDQSPFC---HNWMDLDPEHAVNPIESIDTLTQMVDGKEKTVGRV--VIQNASV 556

  Fly   624 PGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIA----KEDNVNFTCEALAYH 684
            |.:..|:|:|.: ||:.|.:   :..:..|.|     |||.:.:.:    ::|.|...|.|..:.
Zfish   557 PAMYKCLAENKV-GKDERLI---YFYVTTIPE-----GFDIEMEPSEDPLEQDLVQLKCNADNFT 612

  Fly   685 FDGNLKWF-INGEDLK---ESDSVH---------IETSHTKYSYKSTVHITTISDRDRGTYECRA 736
            :: ||:|: ::.:.:.   :..|:|         :....|..::...::||.|..:|.|.|.|..
Zfish   613 YE-NLRWYRLDPQTVPPELDCKSLHQYATFLEGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEV 676

  Fly   737 YHNDKDAVYSSR--------EIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVA 793
            .:......:..|        |...|.|:|     ||     |:.   .:|::|::.|.....|..
Zfish   677 QNRRTGVKHCHRKYIPVKAMEAPRYRHNP-----TN-----HTV---NVSESLQMNCDVEGTPFP 728

  Fly   794 IVRWFKDDKEVTESKLRHIIEKESK--LLITHLYPGDEGVYKCVVENRLDRIERSFTVVI--SD- 853
            .:.||||::.:  .::..|:.::|.  |.|..:...|.|:|.|...|:...::.|.||.:  ||
Zfish   729 QLSWFKDNQPL--HQISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSVIGSDD 791

  Fly   854 --------LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHI- 909
                    |.|..:..::|.|:|.:|...                  :|....|:.:.|.:..|
Zfish   792 KTNVEIVILIGTGVIAIFFWVLLLVIFCN------------------VKRVNPADIKTGYLSIIM 838

  Fly   910 NP-DLTLDEQAELLPY-NREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVK 972
            :| ::.|:||.|.||| :.::|..|:.|:|||.||.||||.|::....|..::....||||||:|
Zfish   839 DPGEVPLEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLK 903

  Fly   973 ATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKC 1037
            ..|.....:||:|||||::|:|.||||||||||.||  ....||||||||::||:.|||...|:.
Zfish   904 EGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEYCKYGNLSNFLRAKREF 966

  Fly  1038 FINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRN 1102
            |:       .:.|.|..||.     ::.|....|                :...:..||.|   :
Zfish   967 FL-------PYRDRSPKTQS-----QVRRMIEAG----------------QASQSEHQPST---S 1000

  Fly  1103 SDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAM 1167
            |.|.||                              |..||          .|::
Zfish  1001 STNPPR------------------------------VTVDD----------LWKT---------- 1015

  Fly  1168 TVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSE 1232
            .:|..|||.::|||||||::|:|:|.:|.|||||||||.|:||||||||||||.:|:..:|.:..
Zfish  1016 PLTIEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKG 1080

  Fly  1233 NGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKP 1297
            |.:||:||:|.||:.|.|:::.|||||:|::|||:|||...|||||..:::...:|.||.||..|
Zfish  1081 NARLPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAP 1145

  Fly  1298 KFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTD 1362
            ..|:.|:|.|||.||:..|..||.|..|.:...::|.|:
Zfish  1146 DNASPEIYGIMLACWQGEPRERPTFPALVEILGDLLQEN-------------------------- 1184

  Fly  1363 YLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFP 1427
                                          .||:....:|:.|:.|.                |.
Zfish  1185 ------------------------------SLPEIPFNVSQSSEDDG----------------FS 1203

  Fly  1428 DFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAP-----------EEIPM-L 1480
            ..||.     |.:::...|:.|     :.|.|..|.:|........|           ||:|| :
Zfish  1204 QASSR-----PPSQEEIRLACN-----TLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEM 1258

  Fly  1481 HRSSTGSDGSPEQG--------RRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNMKPPRKN 1537
            ....|..|...:.|        .||....:...:|       |..|   |:.:|..:       :
Zfish  1259 TSHKTQHDSQTDSGMVLASDELERFEHKHRGAMLT-------HATT---GQSTERLI-------S 1306

  Fly  1538 IPGKTTTGGGGAA------AGASTEAFSNPSYQPLS 1567
            .|..:::|.||..      ...|.:.|.|..|..||
Zfish  1307 CPSVSSSGSGGGLLRPVFFTQLSGQTFYNNEYGHLS 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	22/90 (24%)
		Ig	<363..432	CDD:299845	17/73 (23%)
		Ig	466..533	CDD:299845	18/74 (24%)
		IG_like	672..754	CDD:214653	19/102 (19%)
		Ig	674..739	CDD:143165	16/77 (21%)
		IGc2	779..840	CDD:197706	16/62 (26%)
		PKc_like	927..1332	CDD:304357	160/404 (40%)
		Pkinase_Tyr	935..1329	CDD:285015	158/393 (40%)
flt4	NP_571020.2	IG_like	258..348	CDD:214653	25/108 (23%)
		Ig1_VEGFR	265..350	CDD:143270	23/96 (24%)
		IG_like	362..445	CDD:214653	18/93 (19%)
		Ig	373..445	CDD:299845	18/82 (22%)
		Ig	602..685	CDD:143165	16/83 (19%)
		IG	602..678	CDD:214652	16/76 (21%)
		I-set	705..786	CDD:254352	24/95 (25%)
		IGc2	714..776	CDD:197706	16/63 (25%)
		PKc_like	858..1184	CDD:304357	161/408 (39%)
		Pkinase_Tyr	866..1177	CDD:285015	158/393 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1007		10/82 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1212		7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1729
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	1	1.000	-	-		otm25366
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970