DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Ceacam20

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001163795.1	Gene:	Ceacam20 / 292701	RGDID:	1311281	Length:	579	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	191/506 - (37%)	Gaps:	127/506 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 TDN----SNQNVQRA-------TYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFP 469
            ||:    ||..::||       |.|.:|:.:..      :.:..|......|.||....|
  Rat    33 TDHAELLSNTQMERASLAKPILTVRQRVVTEQR------DMADFYCATNAVNATIHWVFN----- 86

  Fly   470 TPSFSWFKPDGTEVRQSENNFKILSTEL-----STMLQVLNAQLQDSGTYVLRGSNSFGVVQREY 529
                              |:..:|:..:     :..|.||..|.:|||:|:....:.|.|.:.:.
  Rat    87 ------------------NSLLVLNERMKLSADNKNLTVLVVQREDSGSYLCEVQSGFEVGRSDD 133

  Fly   530 NVSVM----DAPALKMSDAYVQVGSVARLE--------CTVRSYPPAIVTFFFRPCSLEPQWPTC 582
            .:..:    |..::|: |:.|..|.|..:.        ...:|||....|::.         ||.
  Rat   134 TLLEVNYGPDPVSIKL-DSGVATGDVVEVMEGNTVNFWVETQSYPAPTYTWYL---------PTD 188

  Fly   583 SVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAH 647
            |:                |..|..|:|::..|..     .:.|:..|:..|.:....|..:.|..
  Rat   189 SI----------------QPPPITGQLTIPAISR-----EQEGMYRCLVSNTVTNSSRLGVVKVQ 232

  Fly   648 VLLGNISENMTIYGFDKDHKIAKEDN---VNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETS 709
            ||     |.:|. .:.:...:|..:|   |..||:  ..|....:.|::.|:.|..|:  |:..|
  Rat   233 VL-----EKVTA-PYIESPTLALVENATSVMLTCK--TSHQRVGVHWYLRGQPLMPSE--HLTLS 287

  Fly   710 HTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYV-HDPSAPQWTNGGQEG-HSK 772
                |...|:.|..:...|.|.|||..::....|  .|..::|.: :.|.....|.|...| .:.
  Rat   288 ----SQNRTLTIHGLQRDDSGPYECEVWNWGSQA--RSVPLELTINYGPDQVDITQGSASGVVNT 346

  Fly   773 IKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVE 837
            |:..|:.:|.|.|.:.:.|.|...|       |......:...: :|.|..|....:|:|.|...
  Rat   347 IEATLNSSLTLHCWADSKPGARYHW-------THEHSSQVFAGD-QLNIEALRQEHQGIYSCTSS 403

  Fly   838 NRLDRIERSFTVVI--------SDLPGISMAWVWFGVILFL-ILIGLCVFL 879
            |.:..:.||.:|::        |..||: :|.:..|::..: ::|||..||
  Rat   404 NNVTGLTRSASVLVTVVGLQSSSMSPGV-IAGIVIGILAAIALVIGLGYFL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	8/26 (31%)
		Ig	<363..432	CDD:299845	8/26 (31%)
		Ig	466..533	CDD:299845	12/71 (17%)
		IG_like	672..754	CDD:214653	22/84 (26%)
		Ig	674..739	CDD:143165	18/64 (28%)
		IGc2	779..840	CDD:197706	14/60 (23%)
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
Ceacam20	NP_001163795.1	Ig	63..139	CDD:299845	17/104 (16%)
		IG_like	158..233	CDD:214653	18/104 (17%)
		IGc2	163..218	CDD:197706	14/84 (17%)
		Ig	250..327	CDD:299845	22/86 (26%)
		IG_like	255..326	CDD:214653	21/80 (26%)
		IG_like	346..417	CDD:214653	19/78 (24%)
		IGc2	352..406	CDD:197706	14/61 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000