DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Pdgfrl

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001011921.1	Gene:	Pdgfrl / 290771	RGDID:	1308028	Length:	375	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	86/445 - (19%)
Similarity:	139/445 - (31%)	Gaps:	171/445 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GENG-APLMTPCKSAI--ILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDN--TEDPARPF-- 99
            |||. .|.....|..|  |.|..|:      |..|      :||.:.:::.||  .:.||...
  Rat    34 GENRIKPTNKKAKPKIPKIKDRDTA------DSAP------KSQSIMMQAMDNGRFQKPAATVSL 86

  Fly   100 --GTSLHL----IEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVN---------------- 142
              |.|:.|    .:|...| .||  :.|.|.|::..::......:.|||
  Rat    87 MAGQSVELRCKGSKVEWSY-PAY--LDTFKDSRLTVKQNERYGQLTLVNSTTADTGEFSCWERLC 148

  Fly   143 QGY--------ASSIYVYVNDPDTKLVDS---HNVVTARQYTDVVIPCKPAMPDTEVLL--ETSN 194
            .||        ..|.|::..:.....|.|   .:||........|:||:...|..:|.|  |...
  Rat   149 NGYICRRDEARTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPA 213

  Fly   195 GEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEE-----------MTSIEVRFI 248
            .|:.::.:...||.:|||.            |.:     ||::.:           .:.|.|::.
  Rat   214 KEIPANGTDIVYDMKRGFV------------YLQ-----PHSDHQGVVYCKAEAGGKSQISVKYQ 261

  Fly   249 ATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPM 313
            ...:::|         :..|..|     :|..:|:       :||||
  Rat   262 LLYVEVP---------SGPPSTT-----ILASSNK-------VRGGD------------------ 287

  Fly   314 NASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDC----EQSAYVESVYGMEWFTPSRDENR 374
                                            :.::.|    |....||    ..|..|.:.:.|
  Rat   288 --------------------------------DISVLCTVLGEPDVEVE----FRWIFPGQKDER 316

  Fly   375 IFASQSRTDPKTRNSTHQT--GRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRAT 427
            ....|.......|...|.|  .:|.:||.:.:..|.|.|.|..     ||::..|
  Rat   317 PVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTA-----QNLRGQT 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	21/88 (24%)
		Ig	<363..432	CDD:299845	17/67 (25%)
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
Pdgfrl	NP_001011921.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..63		11/40 (28%)
		Ig	79..143	CDD:299845	15/66 (23%)
		IG_like	83..>143	CDD:214653	13/62 (21%)
		I-set	272..373	CDD:254352	29/166 (17%)
		Ig	293..372	CDD:299845	21/83 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900