DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Kdr

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus

Alignment Length:	1576	Identity:	395/1576 - (25%)
Similarity:	636/1576 - (40%)	Gaps:	423/1576 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PDDSIENCGGENGAPLMTPCKSAIILDAQTSTTLKCEDDEPMSW-W-----TSQSQYVHVKSFDN 91
            |.||:.       .|.::..|..:.:.|.|:..:.|.....:.| |     .|:.:.:..:..|:
  Rat    25 PGDSLH-------PPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNTPRDSEERVLVTECGDS 82

  Fly    92 TEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDP 156
            .      |..:|.:..|..:...||.|...                    :...:|.:||||.|.
  Rat    83 I------FCKTLTVPRVVGNDTGAYKCFYR--------------------DTDVSSIVYVYVQDH 121

  Fly   157 DTKLV----DSHNVV--TARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGR--YDPQRGFT 213
            .:..:    |.|.:|  |..:...|||||:.::.:..|.|.....|........|  :|.::|||
  Rat   122 RSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEKGFT 186

  Fly   214 IEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVL 278
            |....|...|..:|...    .|:|...||....:..|..|           |        |.||
  Rat   187 IPSYMISYAGMVFCEAK----INDETYQSIMYIVLVVGYRI-----------Y--------DVVL 228

  Fly   279 TVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFT 343
                                       ||.....::|.            .|.|:..:..    |
  Rat   229 ---------------------------SPPHEIELSAG------------EKLVLNCTAR----T 250

  Fly   344 DTNFTLDCEQSAYVESVYGMEWFTPS--RDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPS 406
            :.|..||            ..|..||  ....:|.....::.|.|   ..:...||||:.:...|
  Rat   251 ELNVGLD------------FSWQFPSSKHQHKKIVNRDVKSLPGT---VAKMFLSTLTIDSVTKS 300

  Fly   407 DTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNV-GEP-----SGHYN-VQEYANRTIQMTAN 464
            |.|.|.|            ..|...:.|:|::::.| .:|     ||..: |:......:::...
  Rat   301 DQGEYTC------------TAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVK 353

  Fly   465 FEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREY 529
            :..:|.|...|:: :|   |..|:|:.::..:..|:::|..   :|:|.|.:..:|...:.::.:
  Rat   354 YLSYPAPDIKWYR-NG---RPIESNYTMIVGDELTIMEVSE---RDAGNYTVILTNPISMEKQSH 411

  Fly   530 NVS-VMDAP-------ALKMSDAYVQVGSVARLECTVRSYPPA--IVTFF-------FRPCSLEP 577
            .|| |::.|       .:...|:| |.|::..|.|||.:.||.  |..::       :||....|
  Rat   412 MVSLVVNVPPQIGEKALISPMDSY-QYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPSQTNP 475

  Fly   578 QWPTCSVLN--QNFSLPSEQEKYQFQTRPRPGK-----------LSVERIYEVSFLPTEPGILTC 629
            .  ||....  ::|...::.|..:.|.....||           .:|..:|:            |
  Rat   476 Y--TCKEWRHVKDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYK------------C 526

  Fly   630 IAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFIN 694
            .|.|.....||  :...||:.|   ..:|:....:.   .::::|:..|.|....|: ||.|:..
  Rat   527 EAINKAGRGER--VISFHVIRG---PEITVQPATQP---TEQESVSLLCTADRNTFE-NLTWYKL 582

  Fly   695 GEDLKESDSVHIETSHTK--------YSYKSTVHITTISD-----------RDRGTYECRAYHND 740
            |   .::.|||:..|.|.        :....||...:.:|           :|:|.|.|.|
  Rat   583 G---SQATSVHMGESLTPVCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSA---- 640

  Fly   741 KDAVYSSREI---DLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDK 802
            :|.....|..   .|.:.:..||..| |..|..:   ..:.:|:|:.|.::..|..::.||||::
  Rat   641 QDKKTKKRHCLVKQLVILERMAPMIT-GNLENQT---TTIGETIEVVCPTSGNPTPLITWFKDNE 701

  Fly   803 EVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLD--RIERSF-----------TVVISDL 854
            .:.|.....:.:....|.|..:...|.|:|.|...|.|.  |.|..|           .|:|  |
  Rat   702 TLVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVII--L 764

  Fly   855 PGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHI----NPD-LT 914
            .|.::..::|.::|.::|            :..||         ||..|...|::    :|| |.
  Rat   765 VGTAVIAMFFWLLLVIVL------------RTVKR---------ANEGELKTGYLSIVMDPDELP 808

  Fly   915 LDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNE 978
            |||:.|.|||: .::||||:.|||||.||.||||.|::.:|.||.:.....||||||:|..|.:.
  Rat   809 LDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHS 873

  Fly   979 VVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQIN 1043
            ..|||:|||||::|:|.||||||||||.||  ....||||||:|:|||:..:|...|..|:
  Rat   874 EHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRGKRNEFV---- 932

  Fly  1044 PDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPR 1108
                                          .|.:.|
  Rat   933 ------------------------------PYKSKG----------------------------- 938

  Fly  1109 SGTRAGRTGSGTATYSYDRQMDTCATVMTTVPE---DDQIMSNNSVQPAWRSNYKTDSTEAMTVT 1170
            :..|:|:...|..:....|::|:..:..::...   :::.:|:...:.|....||.      .:|
  Rat   939 ARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKD------FLT 997

  Fly  1171 TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGK 1235
            ...||.::||||:||::|:|:|.:|.|||||||||.|.||||||||||||.:|:..:|.:..:.:
  Rat   998 LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR 1062

  Fly  1236 LPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFA 1300
            ||:||:|.|::.|.|::..|||||:|::|||:|||...||||:..::|...:|.:|.||..|.:.
  Rat  1063 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYT 1127

  Fly  1301 NQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLA 1365
            ..|:|:.||:||.::|..||.|:||.:...|:|                |:|.:   :...||:.
  Rat  1128 TPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLL----------------QANAQ---QDGKDYIV 1173

  Fly  1366 L-------MGSPDELA-PAAPRYVNGHIVPDIRIEELPD------------DYMEMSRDSDPDAC 1410
            |       |.....|: |.:|       |..:..||:.|            .|::.|:.......
  Rat  1174 LPMSETLSMEEDSGLSLPTSP-------VSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVS 1231

  Fly  1411 TAIFSPTRL-EGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQAP 1474
            ...|....| |.|....||.|...:.....:.:..||.:.     :|......||
  Rat  1232 VKTFEDIPLEEPEVKVIPDDSQTDSGMVLASEELKTLEDR-----NKLSPSFGGM---------- 1281

  Fly  1475 EEIPMLHRSSTGSDGS 1490
              :|...|.|..|:||
  Rat  1282 --MPSKSRESVASEGS 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	19/87 (22%)
		Ig	<363..432	CDD:299845	16/70 (23%)
		Ig	466..533	CDD:299845	15/67 (22%)
		IG_like	672..754	CDD:214653	24/103 (23%)
		Ig	674..739	CDD:143165	21/83 (25%)
		IGc2	779..840	CDD:197706	16/60 (27%)
		PKc_like	927..1332	CDD:304357	152/407 (37%)
		Pkinase_Tyr	935..1329	CDD:285015	148/396 (37%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386	31/178 (17%)
		Ig strand A	224..228	CDD:409353	2/11 (18%)
		Ig strand A'	234..238	CDD:409353	0/3 (0%)
		Ig strand B	240..249	CDD:409353	2/8 (25%)
		Ig strand C	256..261	CDD:409353	2/16 (13%)
		Ig strand C'	264..266	CDD:409353	1/1 (100%)
		Ig strand D	270..278	CDD:409353	1/7 (14%)
		Ig strand E	286..294	CDD:409353	3/7 (43%)
		Ig strand F	304..310	CDD:409353	2/17 (12%)
		Ig strand G	315..321	CDD:409353	2/5 (40%)
		Ig	329..417	CDD:416386	18/94 (19%)
		Ig strand A	329..332	CDD:409353	0/2 (0%)
		Ig strand A'	339..343	CDD:409353	1/3 (33%)
		Ig strand B	345..356	CDD:409353	0/10 (0%)
		Ig strand C	360..366	CDD:409353	2/5 (40%)
		Ig strand C'	368..371	CDD:409353	2/5 (40%)
		Ig strand D	376..379	CDD:409353	0/2 (0%)
		Ig strand E	381..386	CDD:409353	1/4 (25%)
		Ig strand F	394..402	CDD:409353	2/7 (29%)
		Ig strand G	408..417	CDD:409353	2/8 (25%)
		Ig_3	547..641	CDD:404760	22/104 (21%)
		IGc2	676..740	CDD:197706	16/63 (25%)
		Ig strand B	680..684	CDD:409353	1/3 (33%)
		Ig strand C	693..697	CDD:409353	0/3 (0%)
		Ig strand E	716..720	CDD:409353	1/3 (33%)
		Ig strand F	730..735	CDD:409353	2/4 (50%)
		VEGFR-2_TMD	755..789	CDD:375470	9/56 (16%)
		PTKc_VEGFR2	822..1163	CDD:270681	155/427 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314		11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1517
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1779
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870