DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Pdgfra

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_036934.1	Gene:	Pdgfra / 25267	RGDID:	3284	Length:	1088	Species:	Rattus norvegicus

Alignment Length:	1466	Identity:	339/1466 - (23%)
Similarity:	551/1466 - (37%)	Gaps:	511/1466 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQ----YVHVKSFDNTEDPARPFGTSLHLIE 107
            |.:.|.::..|:...:|.:|:|..:..:||....|:    .|.:::.:|.   :..|.|.|.::.
  Rat    27 PSILPNENEKIVPLSSSFSLRCFGESEVSWQHPMSEEEDPNVEIRTEENN---SSLFVTVLEVVN 88

  Fly   108 VTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVD---SHNVVTA 169
            .:|.:...|.|        .....|::|:.||      ...||:||.|||...|.   :.::|..
  Rat    89 ASAAHTGWYTC--------YYNHTQTEESEIE------GRHIYIYVPDPDMAFVPLGMTDSLVIV 139

  Fly   170 RQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGF--TIEIRSIVDGGDYYCRPNPP 232
            .:....:|||:...|||||.|. :||.:..:.    ||.::||  |..:      |.|.|
  Rat   140 EEDDSAIIPCRTTDPDTEVTLH-NNGRLVPAS----YDSRQGFNGTFSV------GPYIC----- 188

  Fly   233 FPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGT 297
                  |.|   ||        .||..|:....||...|
  Rat   189 ------EAT---VR--------GRTFKTSEFNVYALKAT-------------------------- 210

  Fly   298 LSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYV----- 357
                                                         ::.|..:|..|:.|.
  Rat   211 ---------------------------------------------SELNLEMDTRQTVYKAGETI 230

  Fly   358 --------ESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCV 414
                    ..|..::|..|....|:...........:....:     ||||..|...|:|.|:|.
  Rat   231 VVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVY-----TLTVPKATVKDSGDYECA 290

  Fly   415 TTDNSNQNVQRATYRIKVLK------QNESYLNVGEPSGH------YNVQEYANRTIQMTANFEG 467
                    .::||..:|.:|      ..:.::.:....||      :.|:|:       ....:.
  Rat   291 --------ARQATKEVKEMKTVTISVHEKGFVQIRPTFGHLETVNLHQVREF-------VVEVQA 340

  Fly   468 FPTPSFSWFKPD----------GTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSF 522
            :|||..||.|.:          .|:|::|:      .|...:.|:::.|:.:|||.|.:...|..
  Rat   341 YPTPRISWLKDNLTLIENLTEITTDVQRSQ------ETRYQSKLKLIRAKEEDSGHYTIIVQNDD 399

  Fly   523 GVVQREYNVS-VMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLN 586
            .:....:.:| ::.|..|::.|.:...|....:.||....|
  Rat   400 DMKSYTFELSTLVPASILELVDDHHGSGGGQTVRCTAEGTP------------------------ 440

  Fly   587 QNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLG 651
                                             ||
  Rat   441 ---------------------------------LP------------------------------ 442

  Fly   652 NISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYK 716
                                                |::|.| .:|:|:.::   :||.|..:..
  Rat   443 ------------------------------------NIEWMI-CKDIKKCNN---DTSWTVLASN 467

  Fly   717 STVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTL 781
            .:..||....|.|.|.|                                |:...:|::    :|:
  Rat   468 VSNIITEFHQRGRSTVE--------------------------------GRVSFAKVE----ETI 496

  Fly   782 ELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERS 846
            .:.|.:           |:|..:.        .:|.||:...|                   ...
  Rat   497 AVRCLA-----------KNDLGIG--------NRELKLVAPTL-------------------RSE 523

  Fly   847 FTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINP 911
            .||..:.|           |:|.::::.|.|.:.:..||..           .......:..|:|
  Rat   524 LTVAAAVL-----------VLLVIVIVSLIVLVVIWKQKPR-----------YEIRWRVIESISP 566

  Fly   912 D----LTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVK 972
            |    :.:|...  |||:..:||||:.|.||:.||:||||.|::|.|.|:.|.:|...|||||:|
  Rat   567 DGHEYIYVDPMQ--LPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK 629

  Fly   973 ATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKC 1037
            .||.:...:||:||||||.|||.|||:||||||.||:   ..:.:|.|||.:|::.|:|.:||..
  Rat   630 PTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKS---GPIYIITEYCFYGDLVNYLHKNRDS 691

  Fly  1038 FINQINPDTDHIDPSIMTQRMSD----NYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQ--P 1096
            |::: :|:....|..|.....:|    :|.:        |.:.|.|    .|::....:.||  |
  Rat   692 FMSR-HPEKPKKDLDIFGLNPADESTRSYVI--------LSFENNG----DYVDMKQADTTQYVP 743

  Fly  1097 PTHRRN----SDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRS 1157
            ...|:.    ||.......|       .|:|.....:|:         |...::|:
  Rat   744 MLERKEVSKYSDIQRSLYDR-------PASYKKKSMLDS---------EAKNLLSD--------- 783

  Fly  1158 NYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSM 1222
                |.:|.:|:  :||:|:.:||||||::|:||..:|.||||||:||.:..:||||||||||.:
  Rat   784 ----DDSEGLTL--LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 842

  Fly  1223 YRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNK 1287
            ....||....:..||:||:|.||:.|::::|.|||||||::|||:|||...||||:..:...:||
  Rat   843 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNK 907

  Fly  1288 LNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSN 1352
            :..||||.||..|..|:||||::||...||.||.|..|.:...|:|.......|..::..:::|:
  Rat   908 IKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD 972

  Fly  1353 IEYMKKQSTD----YLALM------------GSPDELAPAAPRYVNGHIVPDIRIEELP--DDYM 1399
            ...:.:...|    |:.:.            |..||...:|.   :|:|:|...|:.:|  :|..
  Rat   973 HPAVARMRVDSDNAYIGVTYKNEEDKLKEWEGGLDEQRLSAD---SGYIIPLPDIDPVPEEEDLG 1034

  Fly  1400 EMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTF 1435
            :.:|.|...:            |.|.....||.:||
  Rat  1035 KRNRHSSQTS------------EESAIETGSSSSTF 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	19/98 (19%)
		Ig	<363..432	CDD:299845	14/68 (21%)
		Ig	466..533	CDD:299845	18/77 (23%)
		IG_like	672..754	CDD:214653	14/81 (17%)
		Ig	674..739	CDD:143165	14/64 (22%)
		IGc2	779..840	CDD:197706	8/60 (13%)
		PKc_like	927..1332	CDD:304357	164/414 (40%)
		Pkinase_Tyr	935..1329	CDD:285015	160/403 (40%)
Pdgfra	NP_036934.1	Ig_3	27..99	CDD:404760	16/74 (22%)
		Ig	211..309	CDD:416386	21/110 (19%)
		Ig strand A	211..215	CDD:409353	0/3 (0%)
		Ig strand A'	222..226	CDD:409353	1/3 (33%)
		Ig strand B	228..237	CDD:409353	0/8 (0%)
		Ig strand C	242..247	CDD:409353	0/4 (0%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	256..264	CDD:409353	0/7 (0%)
		Ig strand E	268..276	CDD:409353	2/12 (17%)
		Ig strand F	286..292	CDD:409353	2/13 (15%)
		Ig strand G	297..303	CDD:409353	1/5 (20%)
		Ig4_PDGFR	312..412	CDD:409445	22/112 (20%)
		Ig strand B	332..336	CDD:409445	1/10 (10%)
		Ig strand C	345..349	CDD:409445	1/3 (33%)
		Ig strand E	376..380	CDD:409445	1/3 (33%)
		Ig strand F	390..395	CDD:409445	1/4 (25%)
		Ig strand G	403..406	CDD:409445	0/2 (0%)
		PTKc_PDGFR_alpha	554..955	CDD:173653	173/449 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1088		13/54 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1517
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto97159
orthoMCL	1	0.900	-	-		OOG6_106773
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720