DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Fgfr4

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_006253668.1	Gene:	Fgfr4 / 25114	RGDID:	2612	Length:	801	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	235/880 - (26%)
Similarity:	358/880 - (40%)	Gaps:	279/880 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 GKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVL----------LGN-----ISEN 656
            |:|.:     .||||.:.|...|:|        |.::|..|.|          :.|     :|.:
  Rat    81 GRLEI-----ASFLPEDAGRYLCLA--------RGSMTVVHNLTLIMDDSLPSINNEDPKTLSSS 132

  Fly   657 MTIYGF--------------DKDHKIAKEDNVNFTCEALAYHFDGN----LKWFINGEDLKESDS 703
            .:.:.:              .|.|.:...:.|.|.|.|.     ||    :.|..||:.....:.
  Rat   133 SSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAA-----GNPMPTIHWLKNGQAFHGENR 192

  Fly   704 V-HIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQ 767
            : .|...|..:|    :.:.::...|||||.| ...|...::..|..:|:....|..|....|..
  Rat   193 IGGIRLRHQHWS----LVMESVVPSDRGTYTC-LVENSLGSIRYSYLLDVLERSPHRPILQAGLP 252

  Fly   768 EGHSKIKRKLSQTLELECA--STAVPVAIVRWFKDDKEVTESKLRHIIEKESK------------ 818
            ...:.:   :...:||.|.  |.|.|  .::|           |:||:...|.
  Rat   253 ANTTAV---VGSNVELLCKVYSDAQP--HIQW-----------LKHIVINGSSFGADGFPYVQVL 301

  Fly   819 ------------LLITHLYPGDEGVYKCVVENRLD-RIERSFTVVISDLPGISMAWV-------W 863
                        |.:.::...|.|.|.|:..|.:. ..:.::..|:.:.....:||.       :
  Rat   302 KTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEAEEEDLAWTTATSEARY 366

  Fly   864 FGVILFL---ILIGLCVFLAVRYQKE--HKRH--------------------LALKAAGLANFE- 902
            ..:||::   :.:.|.:.||..|.::  |..|                    |..:::|.::..
  Rat   367 TDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSL 431

  Fly   903 -EGA----------VGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKG 956
             .|.          .|.::.||.||..         :||||:.|.|||.||.|.||.|::.||.|
  Rat   432 VRGVRLSSSGPPLLTGLVSLDLPLDPL---------WEFPRDRLVLGKPLGEGCFGQVVRAEALG 487

  Fly   957 I--RREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIV 1019
            :  .|.:.|:||||||:|..|.::.:..|:||:::|..:|:|.|::||||..|:   :..|.|||
  Rat   488 MDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQ---EGPLYVIV 549

  Fly  1020 EYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHS 1084
            ||...||::.||...|
  Rat   550 EYAAKGNLREFLRARR------------------------------------------------- 565

  Fly  1085 YINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNN 1149
                       ||....:.|. |||       ..|..::
  Rat   566 -----------PPGPDLSPDG-PRS-------SEGPLSF-------------------------- 585

  Fly  1150 SVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKIC 1214
               ||                   |:|.|:||||||.||.|:|.:|.||||||:|:.||:|:||.
  Rat   586 ---PA-------------------LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIA 628

  Fly  1215 DFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGID 1279
            ||||||.::..|.|||:.||:||:||:|.|:|.|.|::..|||||:||:|||:|:|...|||||
  Rat   629 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI- 692

  Fly  1280 PNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDL 1344
            |.:|||:.|.:|:|||:|.....|||.:|.|||...|..||.|.:|.:....:| ..|:..||||
  Rat   693 PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDL 756

  Fly  1345 N---NPYMQSNIEYMKKQSTDYLALMGSPDELAPA 1376
            .   .||..:|.:.....|:........|..|.|:
  Rat   757 RLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPS 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	21/86 (24%)
		Ig	674..739	CDD:143165	18/69 (26%)
		IGc2	779..840	CDD:197706	17/86 (20%)
		PKc_like	927..1332	CDD:304357	145/406 (36%)
		Pkinase_Tyr	935..1329	CDD:285015	141/395 (36%)
Fgfr4	XP_006253668.1	IG	40..108	CDD:214652	11/39 (28%)
		IGc2	47..104	CDD:197706	10/35 (29%)
		Ig	153..237	CDD:299845	22/93 (24%)
		IG_like	158..237	CDD:214653	20/88 (23%)
		IG_like	252..346	CDD:214653	17/109 (16%)
		Ig3_FGFR-2	260..347	CDD:143266	17/99 (17%)
		PKc_like	453..766	CDD:304357	156/442 (35%)
		Pkinase_Tyr	466..742	CDD:285015	141/395 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810