DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Ret

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_036775.2	Gene:	Ret / 24716	RGDID:	3556	Length:	1115	Species:	Rattus norvegicus

Alignment Length:	1055	Identity:	268/1055 - (25%)
Similarity:	421/1055 - (39%)	Gaps:	327/1055 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PSGHYNVQEYANRTI------QMTANFEGFPTPSFSWFKPDGTEVRQSENNFKI-----LSTELS 498
            |:....|:.|.:..:      |.|...|  .||:.:..:.:...||.:.:|:|:     ||...|
  Rat   306 PASGELVRRYTSTLLSGDSWAQQTFRVE--HTPNETLVQSNNNSVRATMHNYKLVLNRSLSISES 368

  Fly   499 TMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDA----------PALKMSDAYVQVGSVAR 553
            .:||:: ..:.||.   .:|..| ||:...:||||:..          |..:.:..|.|:|.|..
  Rat   369 RVLQLV-VLVNDSD---FQGPGS-GVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCV 428

  Fly   554 LECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVE-----R 613
            ..|  :.:....:.:     .|:|....||.|....|           |....|.|.|.     |
  Rat   429 ENC--QEFSGVSIQY-----KLQPSSTNCSALGVVTS-----------TEDTSGTLYVNDTEALR 475

  Fly   614 IYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLL---GN-ISENMTIYGFDKDHKIAKEDNV 674
            ..|.:.|.     .|.:|.:    ::.|..|:|.:::   |. |:|.:   |..|...:.|....
  Rat   476 RPECTELQ-----YTVVATD----RQTRRQTQASLVVTVEGTYIAEEV---GCPKSCAVNKRRPE 528

  Fly   675 NFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHN 739
            ...|..|... .|..:|       ::.|...|           |.:.:|.|.   .|..|...|.
  Rat   529 CEECGGLGSP-TGRCEW-------RQGDGKGI-----------TRNFSTCSP---STRTCPDGHC 571

  Fly   740 DKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEV 804
            |   ...||:|::...|........|.:.|              |.........|...|.|:|
  Rat   572 D---ALESRDINICPQDCLRGPIVGGHERG--------------ERQGIKAGYGICNCFPDEK-- 617

  Fly   805 TESKLRHIIEKESKLLITHLYPGDEGVYKCVVENR------LDRIERSFTVVISDLPGISMAWVW 863
                                        ||..|..      .|.:.|  ||:        .|.|.
  Rat   618 ----------------------------KCFCEPEDSQGPLCDELCR--TVI--------TAAVL 644

  Fly   864 FGVILFLILIGLCVFLAVRYQKE-HKRHLALKAAGLANFEEG------AVGHINPDL-TLDEQAE 920
            |..|:.::|...|:.   ||.|. ||..:|..........:|      :.|...|.| :::.|..
  Rat   645 FSFIISVLLSTFCIH---RYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVS 706

  Fly   921 L----LPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVR 981
            :    :|.:.::||||:||.|||.||.|.||.|:|..|..::.....|||||||:|..|....:|
  Rat   707 VDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELR 771

  Fly   982 ALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDT 1046
            .|:||..::..: .|.:|:.|.||.:::   ..|::||||.::|:::.||..:||
  Rat   772 DLLSEFNLLKQV-NHPHVIKLYGACSQD---GPLLLIVEYAKYGSLRGFLRDSRK---------- 822

  Fly  1047 DHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGT 1111
              |.|:.:             ::||.                            |||.:
  Rat   823 --IGPAYV-------------SSGGS----------------------------RNSSS------ 838

  Fly  1112 RAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLIS 1176
                                                             .|..:...:|..||||
  Rat   839 -------------------------------------------------LDHPDERVLTMGDLIS 854

  Fly  1177 WAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWL 1241
            :|:|::|||.||:..|::|.||||||||:.|...:||.||||:|.:|..|:|.|...|::|:||:
  Rat   855 FAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWM 919

  Fly  1242 ALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYE 1306
            |:|||.||:::|.|||||:|::|||:.:|...|||||.| :.|||.|..|:|||:|...::|:|.
  Rat   920 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGHRMERPDNCSEEMYR 983

  Fly  1307 IMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGS-- 1369
            :||:||::.|:.||:||::.|                        ::|.|..:|.|||.|..|
  Rat   984 LMLQCWKQEPDKRPVFADISK------------------------DLEKMMVKSRDYLDLAASTP 1024

  Fly  1370 ------PDELAPAAPRYVNGHIVPDIRIEELPDDYME-----MSRDSDPDACTAIFSP---TRLE 1420
                  .|.|:......|:.:..|..|  .||..::|     ||..:.|..     ||   ||.:
  Rat  1025 SDSLLYDDGLSEEETPLVDCNSAPLPR--SLPSTWIENKLYGMSDPNWPGE-----SPVPLTRAD 1082

  Fly  1421 GESSDFPDFSSETTF 1435
            |.|:.||.:::::.:
  Rat  1083 GTSTGFPRYANDSVY 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	20/71 (28%)
		IG_like	672..754	CDD:214653	16/81 (20%)
		Ig	674..739	CDD:143165	11/64 (17%)
		IGc2	779..840	CDD:197706	8/66 (12%)
		PKc_like	927..1332	CDD:304357	135/404 (33%)
		Pkinase_Tyr	935..1329	CDD:285015	130/393 (33%)
Ret	NP_036775.2	Cadherin	173..248	CDD:278457
		PTKc_RET	724..1013	CDD:173631	133/425 (31%)
		Pkinase_Tyr	725..1006	CDD:285015	130/417 (31%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810