DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and ALK

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens


Alignment Length:1349 Identity:262/1349 - (19%)
Similarity:427/1349 - (31%) Gaps:510/1349 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 GDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSV 337
            |:|::|..|...:.||.           ||           |.:...:||:: .|...|:...:|
Human   640 GEDKILQNTAPKSRNLF-----------ER-----------NPNKELKPGEN-SPRQTPIFDPTV 681

  Fly   338 EHHVFTDTNFT-------LDCEQSAYVESVYGME------------WFTPSRDENRIF---ASQS 380
             |.:||....:       ..| .:||..|...:|            |..|:.|...|.   |:..
Human   682 -HWLFTTCGASGPHGPTQAQC-NNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGG 744

  Fly   381 RTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCV------TTDNSNQNVQRATYRIKVLKQNESY 439
            :....|...:|  |.|.|.:.|.:..|. ||..|      ...::||.:|:.......:.:.|..
Human   745 KGGKNTMMRSH--GVSVLGIFNLEKDDM-LYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIR 806

  Fly   440 LN--VGEPSGHYNVQEYANRTIQMTANFEGFPTPSF---------SWFKPDGTEVRQSENNFKIL 493
            :|  |.|.:|.......|....:|.   :|.|.|..         ...|.|.....:.|||..:|
Human   807 VNRSVHEWAGGGGGGGGATYVFKMK---DGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVL 868

  Fly   494 STELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTV 558
            .         ||.....:|     |...:.           |..:|..:...:|.|:.....|  
Human   869 G---------LNGNSGAAG-----GGGGWN-----------DNTSLLWAGKSLQEGATGGHSC-- 906

  Fly   559 RSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTE 623
                                             |...:|:.::||...|                
Human   907 ---------------------------------PQAMKKWGWETRGGFG---------------- 922

  Fly   624 PGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNF----------TC 678
            .|...|.:.....|          .:.||.:.|       .|.::..||.|:|          ..
Human   923 GGGGGCSSGGGGGG----------YIGGNAASN-------NDPEMDGEDGVSFISPLGILYTPAL 970

  Fly   679 EALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDA 743
            :.:..|.:.|:|.::|.... |.|..|::....|          .|...|.||            
Human   971 KVMEGHGEVNIKHYLNCSHC-EVDECHMDPESHK----------VICFCDHGT------------ 1012

  Fly   744 VYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESK 808
            |.:...:...|.....|.               |..:|.|...::|:..|:|..|.....|...|
Human  1013 VLAEDGVSCIVSPTPEPH---------------LPLSLILSVVTSALVAALVLAFSGIMIVYRRK 1062

  Fly   809 LRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILI 873
            .:.:...:.:|...              |.:|.:: |:.|::....|....|.            
Human  1063 HQELQAMQMELQSP--------------EYKLSKL-RTSTIMTDYNPNYCFAG------------ 1100

  Fly   874 GLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLG 938
                                |.:.:::.:                          |.||:|:.|.
Human  1101 --------------------KTSSISDLK--------------------------EVPRKNITLI 1119

  Fly   939 KQLGAGAFGVVLKGEAKGIRREEPTTTVAVK-MVKATADNEVVRALVSELKIMVHLGQHLNVVNL 1002
            :.||.||||.|.:|:..|:..:.....|||| :.:..::.:.:..|:..|  ::....|.|:|..
Human  1120 RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL--IISKFNHQNIVRC 1182

  Fly  1003 LGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRD 1067
            :|...:::.:   .:::|....|::::||...|                                
Human  1183 IGVSLQSLPR---FILLELMAGGDLKSFLRETR-------------------------------- 1212

  Fly  1068 TNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTC 1132
                                                   ||..                      
Human  1213 ---------------------------------------PRPS---------------------- 1216

  Fly  1133 ATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGD 1197
                               ||:             ::..:||:..|..:|.|..||.....:|.|
Human  1217 -------------------QPS-------------SLAMLDLLHVARDIACGCQYLEENHFIHRD 1249

  Fly  1198 LAARNILL-C--EDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWS 1259
            :||||.|| |  ...|.||.|||:||.:||...|:|.....||:||:..|:..:.:|::.:|.||
Human  1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWS 1314

  Fly  1260 YGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAE 1324
            :|::|||:|||..:|||. ..|||:...:..|.||:.||.....:|.||.:||:..||.||.||.
Human  1315 FGVLLWEIFSLGYMPYPS-KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI 1378

  Fly  1325 LEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDI 1389
            :.:|.      :..:...|:.|..:.  |||         ..:...:|..|..|:...|  ||.:
Human  1379 ILERI------EYCTQDPDVINTALP--IEY---------GPLVEEEEKVPVRPKDPEG--VPPL 1424

  Fly  1390 RIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFP---------------- 1438
            .:.:......|.|..:.|..      ||...|:::..|. ::|.:...|                
Human  1425 LVSQQAKREEERSPAAPPPL------PTTSSGKAAKKPT-AAEISVRVPRGPAVEGGHVNMAFSQ 1482

  Fly  1439 -----------GARQSPTLSNNLNSGS---SKPLRKKNGMPTVDVADQAPEEIPMLHRSSTGSDG 1489
                       |:|..||...|...||   .||.:|.|     .:|.:.|.:     |.:.|.:|
Human  1483 SNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNN-----PIAKKEPHD-----RGNLGLEG 1537

  Fly  1490 SPEQGRRFNQALKQQYVTPTPSPRHHVET-KLNG-----EPSENYVNMK 1532
            |               .|..|    :|.| :|.|     |||....|||
Human  1538 S---------------CTVPP----NVATGRLPGASLLLEPSSLTANMK 1567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 23/113 (20%)
Ig strand C 363..366 CDD:409353 1/14 (7%)
Ig strand E 396..400 CDD:409353 2/3 (67%)
Ig strand F 410..415 CDD:409353 3/10 (30%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 14/83 (17%)
Ig strand B 459..463 CDD:409353 1/3 (33%)
Ig strand C 472..476 CDD:409353 0/12 (0%)
Ig strand E 497..503 CDD:409353 0/5 (0%)
Ig strand F 513..518 CDD:409353 0/4 (0%)
Ig 671..>742 CDD:472250 16/80 (20%)
Ig strand B 674..678 CDD:409353 2/13 (15%)
Ig strand C 687..691 CDD:409353 1/3 (33%)
Ig strand E 717..721 CDD:409353 0/3 (0%)
Ig strand F 731..736 CDD:409353 1/4 (25%)
Ig 779..851 CDD:472250 13/71 (18%)
Ig strand B 781..785 CDD:409570 2/3 (67%)
Ig strand C 794..798 CDD:409570 1/3 (33%)
Ig strand E 816..821 CDD:409570 1/4 (25%)
Ig strand F 831..836 CDD:409570 0/4 (0%)
Ig strand G 844..847 CDD:409570 1/2 (50%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 100/408 (25%)
ALKNP_004295.2 Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012 48..70
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..635 CDD:459878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674 8/46 (17%)
EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673 987..1025 10/60 (17%)
FXa_inhibition 987..1021 CDD:464251 9/56 (16%)
PTKc_ALK_LTK 1109..1385 CDD:270632 100/438 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463 14/63 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540 10/50 (20%)
Blue background indicates that the domain is not in the aligned region.

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