DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and FLT4

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:1685 Identity:416/1685 - (24%)
Similarity:647/1685 - (38%) Gaps:454/1685 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LPRLIL--LPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTL 66
            ||..::  .||.:.||:|..    :..:|..|             |.:...:.:.::|...|.::
Human    79 LPGQVMASFPLTVCLRLSGL----VSGYSMTP-------------PTLNITEESHVIDTGDSLSI 126

  Fly    67 KCEDDEPMSWWTSQSQYVHVKSFDNTED----------PARPFGTSLHLIEVTADYVAAYYCVKT 121
            .|....|:.|....:|........::||          .|||:...|.|.||.|:...:|.|.  
Human   127 SCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCY-- 189

  Fly   122 SKFSQIAKEEQSDEAMIELVNQGYASSIYVYVND--------PDTKLVDSHNVVTARQYTDVVIP 178
              :..|       :|.||...   |:|.||:|.|        |||.||:..:.:.        :|
Human   190 --YKYI-------KARIEGTT---AASSYVFVRDFEQPFINKPDTLLVNRKDAMW--------VP 234

  Fly   179 CKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDGGDYYCRPNPPFPHNEEEMTSI 243
            |..::|...|.|.:.:..:........:|.:||..:....:.|.....|.               
Human   235 CLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCE--------------- 284

  Fly   244 EVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPA 308
                                      .|.||.:.|     |...|..|.|.:             
Human   285 --------------------------TTWGDQDFL-----SNPFLVHITGNE------------- 305

  Fly   309 RLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDEN 373
                         ..|.:.||    |.|:|  :.......|:|...|...|....:|..|.:.  
Human   306 -------------LYDIQLLP----RKSLE--LLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQ-- 349

  Fly   374 RIFASQSRTDPKTRN-STHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNE 437
               |.:.:..|:.|: .||....|.||:.|....|.|.|.|    .:|..:||.....:|:....
Human   350 ---AERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVC----KANNGIQRFRESTEVIVHEN 407

  Fly   438 SYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQ 502
            .:::|....|........:..:::......:|.|.|.|:| ||          |.||...|....
Human   408 PFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYK-DG----------KALSGRHSPHAL 461

  Fly   503 VLNAQLQDS-GTYVLRGSNSFGVVQREYNVS---VMDAPAL-----KMSDAYVQVGSVARLECTV 558
            ||....:.| |||.|...||...::|  |:|   |::.|..     ..|.:.....|...|.||.
Human   462 VLKEVTEASTGTYTLALWNSAAGLRR--NISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTA 524

  Fly   559 RSYP-PAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPT 622
            ...| |..:.:.:||      |..|.:..|......:|:....|.|......:.:.:..:..|.|
Human   525 YGVPLPLSIQWHWRP------WTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDT 583

  Fly   623 EPGILTCIAQNIIDGKERRTLTKAHVLLGNIS-------------ENMTIY--------GFDKDH 666
                    ....::|| .:|::|..:...|:|             :...||        ||..:.
Human   584 --------WTEFVEGK-NKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIES 639

  Fly   667 KIAKE----DNVNFTCEALAYHFDGNLKWF-INGEDLKES---------DSVHIETSHTKYSYKS 717
            |.::|    ..|..:|:|.:|.:: :|:|: :|...|.::         .:||:..:....|.:.
Human   640 KPSEELLEGQPVLLSCQADSYKYE-HLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEE 703

  Fly   718 ----------TVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDP-------SAPQWTNG 765
                      ::.|..::....|.|.|.        |...|..|.:.|..       .||:.|  
Human   704 VAPGARHATLSLSIPRVAPEHEGHYVCE--------VQDRRSHDKHCHKKYLSVQALEAPRLT-- 758

  Fly   766 GQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEG 830
              :..:.:...:|.:||::|.........:.|:||::.:.|.....:.:...||.|..:...|.|
Human   759 --QNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAG 821

  Fly   831 VYKCVVENRLDRIERSFTVVISD-----------LPGISMAWVWFGVILFLILIGLCVFLAVRYQ 884
            .|.|.|.|....:..|.:|.:..           |.|..:..|:|.|:|.||...:         
Human   822 RYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNM--------- 877

  Fly   885 KEHKRHLALKAAGLANFEEGAVGHINP-DLTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFG 947
             ....|..:|...|:..       ::| ::.|:||.|.|.|: .::|||||.|.||:.||.||||
Human   878 -RRPAHADIKTGYLSII-------MDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFG 934

  Fly   948 VVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAK 1012
            .|::..|.||.:.....||||||:|..|.....|||:|||||::|:|.||||||||||.||  .:
Human   935 KVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PQ 997

  Fly  1013 RELMVIVEYCRFGNIQNFLLRNRKCF--INQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKY 1075
            ..||||||:|::||:.|||...|..|  ..:.:|:        ...|.....||.|         
Human   998 GPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPE--------QRGRFRAMVELAR--------- 1045

  Fly  1076 ANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVP 1140
                                 ...||...:|.....|..:|..|....|.|::            
Human  1046 ---------------------LDRRRPGSSDRVLFARFSKTEGGARRASPDQE------------ 1077

  Fly  1141 EDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILL 1205
                      .:..|.|          .:|..||:.::|||||||::|:|:|.:|.|||||||||
Human  1078 ----------AEDLWLS----------PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILL 1122

  Fly  1206 CEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSL 1270
            .|.:|||||||||||.:|:..:|.:..:.:||:||:|.||:.|.|::|.|||||:|::|||:|||
Human  1123 SESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSL 1187

  Fly  1271 AKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANML-- 1333
            ...||||:..|:|...:|.||.||..|:.|...:..|||.||..:|::||.|:||.:...::|  
Human  1188 GASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQG 1252

  Fly  1334 -----GEDVASHYLDLNNPYMQSNIEYMKKQ-STDYLALMGSPDELAP-------AAPRYVNGHI 1385
                 .|:|.     :.....||:.|....| ||..|.:..:..|.:|       .|.||.|...
Human  1253 RGLQEEEEVC-----MAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVS 1312

  Fly  1386 VPDIRIEELPDDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDF-SSETTFNFPGARQSPTLSNN 1449
            .|                     .|.|..:.||.......|.:| .:.||:       ..::.|.
Human  1313 FP---------------------GCLARGAETRGSSRMKTFEEFPMTPTTY-------KGSVDNQ 1349

  Fly  1450 LNSGSSKPLRKKNGMPTVDVADQAPEEIPMLHRSSTG-SDGSPEQGRRFNQALKQQYVTPTPSPR 1513
            .:||             :.:|.:..|:|...||..:| |...|.|    |.|:          .|
Human  1350 TDSG-------------MVLASEEFEQIESRHRQESGFSCKGPGQ----NVAV----------TR 1387

  Fly  1514 HHVETKLNGEPSENYVNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKE 1573
            .|.:::              .|:..|.:...||         :.|.|..|..||..:|::
Human  1388 AHPDSQ--------------GRRRRPERGARGG---------QVFYNSEYGELSEPSEED 1424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 22/86 (26%)
Ig <363..432 CDD:299845 18/69 (26%)
Ig 466..533 CDD:299845 23/70 (33%)
IG_like 672..754 CDD:214653 18/101 (18%)
Ig 674..739 CDD:143165 15/84 (18%)
IGc2 779..840 CDD:197706 16/60 (27%)
PKc_like 927..1332 CDD:304357 160/406 (39%)
Pkinase_Tyr 935..1329 CDD:285015 155/395 (39%)
FLT4XP_011532780.1 Ig_2 215..301 CDD:290606 21/139 (15%)
IG_like 315..404 CDD:214653 25/99 (25%)
Ig1_VEGFR 322..406 CDD:143270 23/92 (25%)
IG_like 420..492 CDD:214653 23/84 (27%)
Ig2_VEGFR-3 429..495 CDD:143271 23/78 (29%)
IG 641..734 CDD:214652 17/101 (17%)
Ig 647..735 CDD:299845 16/96 (17%)
I-set 755..842 CDD:254352 21/90 (23%)
IGc2 770..832 CDD:197706 16/61 (26%)
PTKc_VEGFR3 914..1253 CDD:270680 161/410 (39%)
Pkinase_Tyr 922..1246 CDD:285015 155/395 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 310 1.000 Domainoid score I1325
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 413 1.000 Inparanoid score I1854
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 1 1.000 - - FOG0001573
OrthoInspector 1 1.000 - - otm41363
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X787
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.830

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