DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and FLT3

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:1157 Identity:278/1157 - (24%)
Similarity:441/1157 - (38%) Gaps:310/1157 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 PRPGQDGKPLPKPVIRSSVEHHVFTDTNF-TLDC--------EQSAYVESVYGMEWFTPSRDENR 374
            |...:||..||..|:.|::.....|:.:. .:.|        :.|....|.|.|           
Human     2 PALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPM----------- 55

  Fly   375 IFASQSRTD------PKTRNSTHQ--------TGRSTLTVLNAQPSDTGLYKCV-TTDNSNQNVQ 424
              .|:|..|      |::..:.::        :...||.||...|   |...|: ...:|:.|.|
Human    56 --VSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAP---GNISCLWVFKHSSLNCQ 115

  Fly   425 -------RATYRIKVLKQNESYLNVGEPSGHYNV---QEYANRTIQMTANF-------------- 465
                   |....:.:||..|:      .:|.|.:   .|..|.||..|.:.              
Human   116 PHFDLQNRGVVSMVILKMTET------QAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFR 174

  Fly   466 ------------EGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRG 518
                        |..|.|...|...|.......|.:..::..|...:.::....::      ...
Human   175 KMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIR------CCA 233

  Fly   519 SNSFG-VVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTC 582
            .|..| ...|.:.:.:...|...:...:::||                          ||.|..|
Human   234 RNELGRECTRLFTIDLNQTPQTTLPQLFLKVG--------------------------EPLWIRC 272

  Fly   583 SV--LNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTK 645
            ..  :|..|.|..|.|.         ..|.....:|:|...|                 .||:.:
Human   273 KAVHVNHGFGLTWELEN---------KALEEGNYFEMSTYST-----------------NRTMIR 311

  Fly   646 AHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNL-----KWFINGEDLKESDSV- 704
              :|...:|            .:|:.|...:||.:..:.....|     |.|||..:..|...: 
Human   312 --ILFAFVS------------SVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEID 362

  Fly   705 HIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEG 769
            ..|.......:|:...|.......|.::.|.  ....|..||..:...:.|.|       |....
Human   363 QYEEFCFSVRFKAYPQIRCTWTFSRKSFPCE--QKGLDNGYSISKFCNHKHQP-------GEYIF 418

  Fly   770 HSK-------------IKRKLSQTL------ELECASTAVPVAIVRWFK-DDK------EVTESK 808
            |::             |:|| .|.|      :..|.|...|:....|.| .||      |:||..
Human   419 HAENDDAQFTKMFTLNIRRK-PQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGV 482

  Fly   809 LRHIIEKE--------SKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPG--------I 857
            ......::        |.|.::....|  .:.||...|.|.   .|...::.:.||        |
Human   483 WNRKANRKVFGQWVSSSTLNMSEAIKG--FLVKCCAYNSLG---TSCETILLNSPGPFPFIQDNI 542

  Fly   858 SMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELL 922
            |. :...||.|..|:: |.:.:..:|:|:.:....|:...:....:....::  |....|     
Human   543 SF-YATIGVCLLFIVV-LTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYV--DFREYE----- 598

  Fly   923 PYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSEL 987
             |:.::|||||||:.||.||:||||.|:...|.||.:...:..|||||:|..||:....||:|||
Human   599 -YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 662

  Fly   988 KIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPS 1052
            |:|..||.|.|:||||||.|   ....:.:|.|||.:|::.|:|...|:.|              
Human   663 KMMTQLGSHENIVNLLGACT---LSGPIYLIFEYCCYGDLLNYLRSKREKF-------------- 710

  Fly  1053 IMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEP----HNNNTQPPTH--RRNSDNDPRSGT 1111
                        ||       .:..: |..|::...|    |.|::.|.:.  :.:.|:|..||.
Human   711 ------------HR-------TWTEI-FKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGL 755

  Fly  1112 RAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTV-DLI 1175
            .      |.:.:|                 :|:|        .:.:..:.:..|.:.|.|. ||:
Human   756 H------GNSFHS-----------------EDEI--------EYENQKRLEEEEDLNVLTFEDLL 789

  Fly  1176 SWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKW 1240
            .:|:|||:||::|..|..:|.||||||:|:....|||||||||||.:....||....|.:||:||
Human   790 CFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKW 854

  Fly  1241 LALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELY 1305
            :|.|||.:.:::..||||||||:|||:|||...|||||..:...:..:.:|::|::|.:|.:|:|
Human   855 MAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIY 919

  Fly  1306 EIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNN-----PYMQSN 1352
            .||..||..:...||.|..|.......|.:...:.|.:::.     |:...|
Human   920 IIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQN 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 20/116 (17%)
Ig <363..432 CDD:299845 16/90 (18%)
Ig 466..533 CDD:299845 10/67 (15%)
IG_like 672..754 CDD:214653 17/87 (20%)
Ig 674..739 CDD:143165 13/70 (19%)
IGc2 779..840 CDD:197706 18/81 (22%)
PKc_like 927..1332 CDD:304357 146/411 (36%)
Pkinase_Tyr 935..1329 CDD:285015 140/400 (35%)
FLT3NP_004110.2 ig 256..345 CDD:278476 24/154 (16%)
PKc_like 572..947 CDD:304357 150/450 (33%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/7 (14%)
Pkinase_Tyr 610..943 CDD:285015 140/400 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41363
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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