DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and FGFR2

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	872	Identity:	230/872 - (26%)
Similarity:	340/872 - (38%)	Gaps:	316/872 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 DSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYH-----------NDKDAVYSSREID---- 751
            |.||:..::........:.|...:.||.|.|.|.|..           |..||:.|..:.|
Human    94 DGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDG 158

  Fly   752 --LYVHDPS----APQWTNGGQEGHSKIKRKL-----SQTLELECASTAVPVAIVRWFKDDKEVT 805
              .:|.:.|    ||.|||     ..|::::|     :.|::..|.:...|:..:||.|:.||..
Human   159 AEDFVSENSNNKRAPYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFK 218

  Fly   806 ES------KLRHIIEKESKLLITHLYPGDEGVYKCVVEN---------RLDRIERS--------- 846
            :.      |:|:   :...|::..:.|.|:|.|.|||||         .||.:|||
Human   219 QEHRIGGYKVRN---QHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAG 280

  Fly   847 -----FTVVISDLPGI---------SMAWV----------------------------------- 862
                 .|||..|:..:         .:.|:
Human   281 LPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLA 345

  Fly   863 ---------------------------WFGVI---------------------------LFLILI 873
                                       |..|:                           :|||..
Human   346 LFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIAC 410

  Fly   874 GLCVFLAVRYQKEHKR---------HLALKAAGL---ANFEEGAVGHINPDLT-----LDEQAEL 921
            .:...:..|.:...|:         |...|...|   .:.|..:..:.|..|.     |...|:.
Human   411 MVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADT 475

  Fly   922 ----------LPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEP--TTTVAVKMVKAT 974
                      ||.:.::||||:.|.|||.||.|.||.|:..||.||.:::|  ..||||||:|..
Human   476 PMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 540

  Fly   975 ADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFI 1039
            |..:.:..||||:::|..:|:|.|::|||||.|::   ..|.|||||...||::.:|...|
Human   541 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARR---- 598

  Fly  1040 NQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSD 1104
                                                                    ||
Human   599 --------------------------------------------------------PP------- 600

  Fly  1105 NDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTV 1169
                           ...||||         :..|||:.                         :
Human   601 ---------------GMEYSYD---------INRVPEEQ-------------------------M 616

  Fly  1170 TTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENG 1234
            |..||:|..:|:||||:||:|:|.:|.||||||:|:.|:||:||.||||||.:...|.|||:.||
Human   617 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG 681

  Fly  1235 KLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKF 1299
            :||:||:|.|:|.|.|::..|||||:|:::||:|:|...||||| |.:|||..|.:|:||:||..
Human   682 RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPAN 745

  Fly  1300 ANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQST--- 1361
            ...|||.:|.:||...|..||.|.:|.:....:|.......||||:.|..|.:..|...:|:
Human   746 CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSS 810

  Fly  1362 -DYLALMGSPDELAPAAPRY--VNGHI 1385
             |.......|....|..|:|  :||.:
Human   811 GDDSVFSPDPMPYEPCLPQYPHINGSV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	15/68 (22%)
		Ig	674..739	CDD:143165	10/47 (21%)
		IGc2	779..840	CDD:197706	20/75 (27%)
		PKc_like	927..1332	CDD:304357	143/406 (35%)
		Pkinase_Tyr	935..1329	CDD:285015	139/395 (35%)
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174	10/48 (21%)
		IG_like	66..143	CDD:214653	10/48 (21%)
		Ig2_FGFR	183..267	CDD:143265	22/86 (26%)
		IG_like	282..376	CDD:214653	6/93 (6%)
		Ig3_FGFR	290..377	CDD:143175	3/86 (3%)
		PTKc_FGFR2	474..786	CDD:270679	146/431 (34%)
		Pkinase_Tyr	499..775	CDD:285015	139/395 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810