DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and FGFR3

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens


Alignment Length:992 Identity:265/992 - (26%)
Similarity:383/992 - (38%) Gaps:333/992 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   467 GFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQR---E 528
            |.|.....|.| |||.:..||   ::|..  ...||||||..:|||.|..|..    :.||   .
Human    66 GGPMGPTVWVK-DGTGLVPSE---RVLVG--PQRLQVLNASHEDSGAYSCRQR----LTQRVLCH 120

  Fly   529 YNVSVMDAPAL--------KMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVL 585
            ::|.|.|||:.        :..|..|..|:                          |.|      
Human   121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGA--------------------------PYW------ 153

  Fly   586 NQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLL 650
                            |||       ||:                        :::.|.      
Human   154 ----------------TRP-------ERM------------------------DKKLLA------ 165

  Fly   651 GNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGN----LKWFINGEDLKESDSV-HIETSH 710
                             :...:.|.|.|.|.     ||    :.|..||.:.:....: .|:..|
Human   166 -----------------VPAANTVRFRCPAA-----GNPTPSISWLKNGREFRGEHRIGGIKLRH 208

  Fly   711 TKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKR 775
            .::|    :.:.::...|||.|.| ...|...::..:..:|:....|..|....|.....:.:  
Human   209 QQWS----LVMESVVPSDRGNYTC-VVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAV-- 266

  Fly   776 KLSQTLELECA--STAVPVAIVRWFKDDKEVTESK---------------LRHIIEKESKLLITH 823
             |...:|..|.  |.|.|  .::|.| ..||..||               :...:|.:.:|.:.:
Human   267 -LGSDVEFHCKVYSDAQP--HIQWLK-HVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLAN 327

  Fly   824 LYPGDEGVYKCVVENRLDRIERSF------------TVVISDLPGISMAWVW-FGVILFLILIGL 875
            :...|.|.|.|...|.:...|::|            .:|.:|..|...|.:. :||..||.::.:
Human   328 VSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVV 392

  Fly   876 CVFLAVRYQKEHKRHLA-----------LKAAGLANFEEGAVGHINPDL------------TLDE 917
            ......|.:...|:.|.           ||.....:.|..|....|..|            ||..
Human   393 AAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLAN 457

  Fly   918 QAEL-LPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPT--TTVAVKMVKATADNEV 979
            .:|| ||.:.::|..|..|.|||.||.|.||.|:..||.||.::...  .||||||:|..|.::.
Human   458 VSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 522

  Fly   980 VRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINP 1044
            :..||||:::|..:|:|.|::|||||.|:.   ..|.|:|||...||::.||...|         
Human   523 LSDLVSEMEMMKMIGKHKNIINLLGACTQG---GPLYVLVEYAAKGNLREFLRARR--------- 575

  Fly  1045 DTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRS 1109
                                                               ||            
Human   576 ---------------------------------------------------PP------------ 577

  Fly  1110 GTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDL 1174
                          ..|...|||.      |.::|:                        |..||
Human   578 --------------GLDYSFDTCK------PPEEQL------------------------TFKDL 598

  Fly  1175 ISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIK 1239
            :|.|:||||||:||:|:|.:|.||||||:|:.||||:||.||||||.::..|.|||:.||:||:|
Human   599 VSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVK 663

  Fly  1240 WLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQEL 1304
            |:|.|:|.|.|::..|||||:|::|||:|:|...||||| |.:|||..|.:|:||:||.....:|
Human   664 WMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDL 727

  Fly  1305 YEIMLECWRKNPESRPLFAELEK---RFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLAL 1366
            |.||.|||...|..||.|.:|.:   |...:...|  ..||||:.|:.|.:   ...|.|...:.
Human   728 YMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD--QEYLDLSAPFEQYS---PGGQDTPSSSS 787

  Fly  1367 MG-----SPDELAPAAP 1378
            .|     :.|.|.||.|
Human   788 SGDDSVFAHDLLPPAPP 804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652
Ig <363..432 CDD:299845
Ig 466..533 CDD:299845 24/68 (35%)
IG_like 672..754 CDD:214653 19/86 (22%)
Ig 674..739 CDD:143165 17/69 (25%)
IGc2 779..840 CDD:197706 18/77 (23%)
PKc_like 927..1332 CDD:304357 145/409 (35%)
Pkinase_Tyr 935..1329 CDD:285015 142/398 (36%)
FGFR3XP_006713931.1 IGc2 53..110 CDD:197706 20/49 (41%)
IG 54..125 CDD:214652 24/68 (35%)
Ig2_FGFR 161..245 CDD:143265 19/116 (16%)
IG_like 171..245 CDD:214653 18/83 (22%)
IG_like 260..355 CDD:214653 21/100 (21%)
Ig3_FGFR 268..356 CDD:143175 20/90 (22%)
PKc_like 463..797 CDD:304357 157/458 (34%)
Pkinase_Tyr 476..752 CDD:285015 142/395 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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