DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and FGFR1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	938	Identity:	237/938 - (25%)
Similarity:	380/938 - (40%)	Gaps:	288/938 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 SFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDA 536
            |.:|.: ||.::.:| |..:|...|    ::|.::...|||.|....|:..|.....::|:|.||
Human    96 SINWLR-DGVQLAES-NRTRITGEE----VEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDA 154

  Fly   537 -PALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQF 600
             |:.:..|                                          :.:.|  |.:||...
Human   155 LPSSEDDD------------------------------------------DDDDS--SSEEKETD 175

  Fly   601 QTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKD 665
            .|  :|.::.|...:      |.|                              |.|.    .|.
Human   176 NT--KPNRMPVAPYW------TSP------------------------------EKME----KKL 198

  Fly   666 HKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKS-TVHITTISDRDR 729
            |.:.....|.|.|.:.... :..|:|..||::.|....:    ...|..|.: ::.:.::...|:
Human   199 HAVPAAKTVKFKCPSSGTP-NPTLRWLKNGKEFKPDHRI----GGYKVRYATWSIIMDSVVPSDK 258

  Fly   730 GTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAI 794
            |.|.| ...|:..::..:.::|:....|..| ....|...:..:  .|...:|..|...:.|...
Human   259 GNYTC-IVENEYGSINHTYQLDVVERSPHRP-ILQAGLPANKTV--ALGSNVEFMCKVYSDPQPH 319

  Fly   795 VRWFKDDKEVTESKLR---------------HIIEKESKLL-ITHLYPGDEGVYKCVVENRLDRI 843
            ::|.| ..||..||:.               :..:||.::| :.::...|.|.|.|:..|.:...
Human   320 IQWLK-HIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLS 383

  Fly   844 ERS--FTVV--ISDLPGISMAWVWFGVILF---LILIGLCVFLAVRYQKE--------------H 887
            ..|  .||:  :.:.|.:..:.::..:|::   ..||...|...:.|:.:              |
Human   384 HHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH 448

  Fly   888 K--------RHLALKAAGLANFEEGAV--------GHINPDLTLDEQAELLPYNREFEFPRENLK 936
            |        |.:.:.|...|:...|.:        ....|.|....:.| ||.:..:|.||:.|.
Human   449 KLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYE-LPEDPRWELPRDRLV 512

  Fly   937 LGKQLGAGAFGVVLKGEAKGIRREEP--TTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNV 999
            |||.||.|.||.|:..||.|:.:::|  .|.|||||:|:.|..:.:..|:||:::|..:|:|.|:
Human   513 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI 577

  Fly  1000 VNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYEL 1064
            :|||||.|::   ..|.|||||...||::.:|...|.
Human   578 INLLGACTQD---GPLYVIVEYASKGNLREYLQARRP---------------------------- 611

  Fly  1065 HRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQM 1129
                  .||:|.         .|..||
Human   612 ------PGLEYC---------YNPSHN-------------------------------------- 623

  Fly  1130 DTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVL 1194
                      ||:.                         :::.||:|.|:||||||:||:|||.:
Human   624 ----------PEEQ-------------------------LSSKDLVSCAYQVARGMEYLASKKCI 653

  Fly  1195 HGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWS 1259
            |.||||||:|:.||||:||.||||||.::..|.|||:.||:||:||:|.|:|.|.:::..|||||
Human   654 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 718

  Fly  1260 YGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAE 1324
            :|::|||:|:|...||||: |.:|||..|.:|:||:||.....|||.:|.:||...|..||.|.:
Human   719 FGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 782

  Fly  1325 LEKRF--------ANMLGEDVASHYLDL 1344
            |.:..        ..:|..|:.:|.|.|
Human   783 LVEDLDRIVALTSNQVLHPDLTTHLLPL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	16/60 (27%)
		IG_like	672..754	CDD:214653	16/82 (20%)
		Ig	674..739	CDD:143165	14/65 (22%)
		IGc2	779..840	CDD:197706	17/76 (22%)
		PKc_like	927..1332	CDD:304357	141/414 (34%)
		Pkinase_Tyr	935..1329	CDD:285015	138/395 (35%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	16/60 (27%)
		IG_like	77..151	CDD:214653	16/60 (27%)
		I-set	193..280	CDD:254352	18/96 (19%)
		Ig2_FGFR	196..280	CDD:143265	17/89 (19%)
		IG_like	295..391	CDD:214653	19/98 (19%)
		Ig3_FGFR	303..392	CDD:143175	19/89 (21%)
		PTKc_FGFR1	497..797	CDD:270678	144/420 (34%)
		Pkinase_Tyr	511..787	CDD:285015	138/395 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810