DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and Tie1

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_035717.2 Gene:Tie1 / 21846 MGIID:99906 Length:1134 Species:Mus musculus


Alignment Length:1446 Identity:310/1446 - (21%)
Similarity:497/1446 - (34%) Gaps:440/1446 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 MLPRLIL---------LPLLLILRISWSDAVPLQQFSPDPDDSIENC-GGENGAPLMTPCKSAII 57
            :||.|.|         |.||..|||:            ||......| .||.||           
Mouse     9 LLPTLFLASHVGASVDLTLLANLRIT------------DPQRFFLTCVSGEAGA----------- 50

  Fly    58 LDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLI-----EVT-------A 110
             ...:...|..|.|:.:           |::|        |.|..|:|.     :||       :
Mouse    51 -GRSSDPPLLLEKDDRI-----------VRTF--------PPGQPLYLARNGSHQVTLRGFSKPS 95

  Fly   111 DYVAAYYCV--KTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHNVVTARQYT 173
            |.|..:.||  ..::.:::.....|..|.:      :...:...||..||.::.:|  |...:.|
Mouse    96 DLVGVFSCVGGAGARRTRVLYVHNSPGAHL------FPDKVTHTVNKGDTAVLSAH--VHKEKQT 152

  Fly   174 DVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSI--VDGGDY---YCRPNPPF 233
            ||:              ..:||...::......|..| |.::::::  ...|.|   |...:|  
Mouse   153 DVI--------------WKNNGSYFNTLDWQEADDGR-FQLQLQNVQPPSSGIYSATYLEASP-- 200

  Fly   234 PHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVL--TVTNQSTGNLALIRGGDG 296
                  :.|...|.|..|....|         :.||........|  .|.:...|......|..|
Mouse   201 ------LGSAFFRLIVRGCGAGR---------WGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTG 250

  Fly   297 TLSRERARRSPARLAPMNASPSPRPGQDGKP-----LPKPV-------IRSSVEHHVFTDTNFTL 349
            |...:..|.  .|..  .:.....||..|..     ||.|.       .|.|.........:|..
Mouse   251 TRCEQACRE--GRFG--QSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGA 311

  Fly   350 DCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCV 414
            ||......::....:.|:            ....|...:..|                     |.
Mouse   312 DCRLQCQCQNGGTCDRFS------------GCVCPSGWHGVH---------------------CE 343

  Fly   415 TTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPT-PSFSWFKP 478
            .:|...|.:..||         |...|:|           ....|...|....||. .|....||
Mouse   344 KSDRIPQILSMAT---------EVEFNIG-----------TMPRINCAAAGNPFPVRGSMKLRKP 388

  Fly   479 DGTEVRQSENNFKILSTEL-------STMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV--- 533
            |||         .:|||::       :...:|.:..|.|||.:..|.|.|.|...|.:.|:|   
Mouse   389 DGT---------MLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVP 444

  Fly   534 ---MDAPAL--KMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSV-LNQNFSLP 592
               :.||.|  |.|...|    |:.|.......|.:.|...:||......|....| .::|.:|.
Mouse   445 PVPLTAPRLLAKQSRQLV----VSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLM 505

  Fly   593 SEQEKYQFQTR---PRPGKLSVERIYEVSFLPT----EPGILTCIAQNIIDGKERRTLTKAHVLL 650
            :.:.|..:..|   .|||: ..|..:..|.|.|    ||.:...:....::|.:|..::.:...:
Mouse   506 NLKPKTGYNVRVQLSRPGE-GGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSV 569

  Fly   651 GNISENMTIYGFDKDHKIAKEDNVNFTCEALAY--------HFDGNLKWF---INGEDLKESDSV 704
            ....:...:..:|......:.:|::|.....|.        |:..:::.:   :.|   ..|...
Mouse   570 PLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLLG---PASPPA 631

  Fly   705 HIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSA---------- 759
            |:....:.......:|...:||                     .||.|....|.|          
Mouse   632 HVHLPPSGPPAPRHLHAQALSD---------------------SEIQLMWQHPEAPSGPISKYIV 675

  Fly   760 ----------PQWTNGGQ-EGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHII 813
                      |||.:..: |..|.|.|.|:.:........|....:..|   ...|.|:.|.:.:
Mouse   676 EIQVAGGSGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDW---SNTVEEATLGNGL 737

  Fly   814 EKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVF 878
            :.|..  :......:||         ||:     .:|::.:..:|       .....||..|...
Mouse   738 QSEGP--VRESRAAEEG---------LDQ-----QLVLAVVGSVS-------ATCLTILAALLAL 779

  Fly   879 LAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFP---RENLKLGKQ 940
            :.:|....|:|......:|  :.||..:...:..|||..:.:  |......:|   .|::.....
Mouse   780 VCIRRSCLHRRRTFTYQSG--SGEETILQFSSGTLTLTRRPK--PQPEPLSYPVLEWEDITFEDL 840

  Fly   941 LGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGA 1005
            :|.|.||.|::..   |:::......|:||:|..|.....|....||:::..||.|.|::|||||
Mouse   841 IGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA 902

  Fly  1006 VTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNG 1070
            ...   :..|.:.:||..:||:.:||.::|                                   
Mouse   903 CEN---RGYLYIAIEYAPYGNLLDFLRKSR----------------------------------- 929

  Fly  1071 GGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATV 1135
                                                                             
Mouse   930 ----------------------------------------------------------------- 929

  Fly  1136 MTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAA 1200
               |.|.|         ||:...:.|    |.|:::..|:.:|...|.||.|||.|:.:|.||||
Mouse   930 ---VLETD---------PAFAREHGT----ASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAA 978

  Fly  1201 RNILLCEDNVVKICDFGLARSMYRGDN-YKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVL 1264
            ||:|:.|:...||.||||:    ||:. |.|...|:||::|:|:|||:..|::|.|||||:|::|
Mouse   979 RNVLVGENLASKIADFGLS----RGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLL 1039

  Fly  1265 WEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF 1329
            ||:.||...||.|: ...||:.||..|||||:|:..:.|:||:|.:|||..|..||.||::..:.
Mouse  1040 WEIVSLGGTPYCGM-TCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL 1103

  Fly  1330 ANMLGEDVASHYLDLN 1345
            ..||  :....|::::
Mouse  1104 GRML--EARKAYVNMS 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 11/85 (13%)
Ig <363..432 CDD:299845 8/68 (12%)
Ig 466..533 CDD:299845 22/74 (30%)
IG_like 672..754 CDD:214653 13/92 (14%)
Ig 674..739 CDD:143165 9/75 (12%)
IGc2 779..840 CDD:197706 8/60 (13%)
PKc_like 927..1332 CDD:304357 115/408 (28%)
Pkinase_Tyr 935..1329 CDD:285015 113/394 (29%)
Tie1NP_035717.2 ig 127..208 CDD:278476 19/105 (18%)
IG_like 131..210 CDD:214653 20/103 (19%)
EGF_Lam 225..263 CDD:238012 8/39 (21%)
EGF_CA 312..343 CDD:238011 5/63 (8%)
ig 353..439 CDD:278476 28/114 (25%)
IG 367..441 CDD:214652 24/82 (29%)
fn3 447..518 CDD:278470 18/74 (24%)
fn3 546..628 CDD:278470 8/84 (10%)
FN3 640..732 CDD:238020 20/115 (17%)
PTKc_Tie1 832..1128 CDD:270671 117/415 (28%)
TyrKc 835..1103 CDD:197581 113/394 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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