DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and EPHA3

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_005224.2 Gene:EPHA3 / 2042 HGNCID:3387 Length:983 Species:Homo sapiens


Alignment Length:1101 Identity:223/1101 - (20%)
Similarity:388/1101 - (35%) Gaps:381/1101 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 VGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDG-----TEVR---------QSENNF-- 490
            :.:||...|:.:  ::|||....:..:  ||..|.:..|     |.:|         .|:||:  
Human    23 IPQPSNEVNLLD--SKTIQGELGWISY--PSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLR 83

  Fly   491 ----------------KILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDAPAL 539
                            |....:.:::..||....:....|.:...:..||..||:..:.:|..|.
Human    84 TNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAA 148

  Fly   540 KMSDAYVQVGS-VARLECTVRSYPP-----------------AIVT--FFFRP------------ 572
            ..|...:.:|. :.:|...:|...|                 |:|:  .:|:.            
Human   149 DESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFP 213

  Fly   573 ------------------------------CSLEPQW----PTCSVLNQNFSLPSEQEKYQFQTR 603
                                          ||.|.:|    ..|| .|..:    |:..:..|. 
Human   214 DTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCS-CNAGY----EERGFMCQA- 272

  Fly   604 PRPG-KLSVERIYEVSFLP-----TEPGILTCIAQNIIDGKER--------RTLTKAHVLLGNIS 654
            .||| ..:::...:.:..|     .|.|.:.|..:|.....::        |..:....::.||:
Human   273 CRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNIN 337

  Fly   655 ENMTI--YGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSY-K 716
            |...|  :.:..|....|:...|..|:...:    |:|..       |..|.::.....::.. .
Human   338 ETSVILDWSWPLDTGGRKDVTFNIICKKCGW----NIKQC-------EPCSPNVRFLPRQFGLTN 391

  Fly   717 STVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHS-----KIKRK 776
            :||.:|.:......|:|.       |||....|:.......:|...|. .|...|     |..|.
Human   392 TTVTVTDLLAHTNYTFEI-------DAVNGVSELSSPPRQFAAVSITT-NQAAPSPVLTIKKDRT 448

  Fly   777 LSQTLELECASTAVPVAI-----VRWF-KDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCV 835
            ...::.|.......|..|     |::: |.::|.:.:.||   .:.:.:.|:.|.|  :.:|...
Human   449 SRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILR---ARGTNVTISSLKP--DTIYVFQ 508

  Fly   836 VENR-------------LDRIERSFTV------VISDLPGISMAWVWFGVILFLILIGLCVFLAV 881
            :..|             .:....||::      |:......::|.:...|::::::...|.:.:.
Human   509 IRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSK 573

  Fly   882 RYQKEHKRHLA---LKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRE----NLKLGK 939
            ....|.:.|..   ||..||..:       ::|....|      |.....||.:|    |:.:.|
Human   574 HGADEKRLHFGNGHLKLPGLRTY-------VDPHTYED------PTQAVHEFAKELDATNISIDK 625

  Fly   940 QLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQ--HLNVVNL 1002
            .:|||.||.|..|..|...::|  .:||:|.:|.....:..|..:.|..||   ||  |.|::.|
Human   626 VVGAGEFGEVCSGRLKLPSKKE--ISVAIKTLKVGYTEKQRRDFLGEASIM---GQFDHPNIIRL 685

  Fly  1003 LGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRD 1067
            .|.|||:   :.:|::.||...|::.:||   ||                               
Human   686 EGVVTKS---KPVMIVTEYMENGSLDSFL---RK------------------------------- 713

  Fly  1068 TNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTC 1132
                                                                     :|.|.   
Human   714 ---------------------------------------------------------HDAQF--- 718

  Fly  1133 ATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGD 1197
                                                 |.:.|:.....:|.||.|||....:|.|
Human   719 -------------------------------------TVIQLVGMLRGIASGMKYLSDMGYVHRD 746

  Fly  1198 LAARNILLCEDNVVKICDFGLARSMYRGDNYK---KSENGKLPIKWLALESLSDHVFSTYSDVWS 1259
            |||||||:..:.|.|:.||||:|.:  .|:.:   .:..||:||:|.:.|:::...|::.|||||
Human   747 LAARNILINSNLVCKVSDFGLSRVL--EDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWS 809

  Fly  1260 YGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAE 1324
            |||||||:.|..:.||..:. ||::...:::|||:..|......||::||:||:|:..:||.|.:
Human   810 YGIVLWEVMSYGERPYWEMS-NQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQ 873

  Fly  1325 ----LEK----------------RFANMLGEDVASHYLDLNNPYMQSNIEYMKKQST-DYL 1364
                |:|                |.:|:|        ||      |||::....::| |:|
Human   874 IVSILDKLIRNPGSLKIITSAAARPSNLL--------LD------QSNVDITTFRTTGDWL 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653
Ig strand C 363..366 CDD:409353
Ig strand E 396..400 CDD:409353
Ig strand F 410..415 CDD:409353
Ig strand G 425..428 CDD:409353
Ig 458..533 CDD:472250 20/106 (19%)
Ig strand B 459..463 CDD:409353 2/3 (67%)
Ig strand C 472..476 CDD:409353 1/3 (33%)
Ig strand E 497..503 CDD:409353 0/5 (0%)
Ig strand F 513..518 CDD:409353 1/4 (25%)
Ig 671..>742 CDD:472250 11/71 (15%)
Ig strand B 674..678 CDD:409353 1/3 (33%)
Ig strand C 687..691 CDD:409353 1/3 (33%)
Ig strand E 717..721 CDD:409353 2/3 (67%)
Ig strand F 731..736 CDD:409353 2/4 (50%)
Ig 779..851 CDD:472250 15/96 (16%)
Ig strand B 781..785 CDD:409570 1/3 (33%)
Ig strand C 794..798 CDD:409570 2/8 (25%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 1/4 (25%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 107/433 (25%)
EPHA3NP_005224.2 EphR_LBD_A3 29..201 CDD:198449 31/175 (18%)
FN3 <323..>543 CDD:442628 43/243 (18%)
FN3 437..528 CDD:238020 16/95 (17%)
EphA2_TM 555..618 CDD:464211 14/75 (19%)
PTKc_EphR_A 616..882 CDD:270651 103/407 (25%)
SAM_superfamily 912..974 CDD:472832 3/9 (33%)
PDZ-binding. /evidence=ECO:0000255 981..983
Blue background indicates that the domain is not in the aligned region.

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