DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and Ret

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_033076.2 Gene:Ret / 19713 MGIID:97902 Length:1115 Species:Mus musculus


Alignment Length:1055 Identity:261/1055 - (24%)
Similarity:415/1055 - (39%) Gaps:327/1055 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   445 PSGHYNVQEYANRTI------QMTANFEGFPTPSFSWFKPDGTEVRQSENNFKI-----LSTELS 498
            |:....|:.|.|..:      |.|...|..|..:.  .:.:...||.:.:|:|:     ||...|
Mouse   306 PASGELVRRYTNTLLSGDSWAQQTFRVEHSPIETL--VQVNNNSVRATMHNYKLILNRSLSISES 368

  Fly   499 TMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSVMDA----------PALKMSDAYVQVGSVAR 553
            .:|| |...:.||.   .:|..:.|::...:||||:..          |..|.:..|.|:|.|..
Mouse   369 RVLQ-LAVLVNDSD---FQGPGAGGILVLHFNVSVLPVTLNLPRAYSFPVNKRARRYAQIGKVCV 429

  Fly   554 LECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQT------RPRPGKLSVE 612
            ..|  :.:....:.:..:|.|:     .|:.|....| |.:.....|..      ||...||.  
Mouse   430 ENC--QEFSGVSIQYKLQPSSI-----NCTALGVVTS-PEDTSGTLFVNDTEALRRPECTKLQ-- 484

  Fly   613 RIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLL----GNISENMTIYGFDKDHKIAKEDN 673
              |.|                :...::.|..|:|.:::    .:|:|.:   |..|...:.|...
Mouse   485 --YTV----------------VATDRQTRRQTQASLVVTVEGTSITEEV---GCPKSCAVNKRRP 528

  Fly   674 VNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYH 738
            ....|..|... .|..:|       ::.|...|           |.:.:|.|.   .|..|...|
Mouse   529 ECEECGGLGSP-TGRCEW-------RQGDGKGI-----------TRNFSTCSP---STRTCPDGH 571

  Fly   739 NDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKE 803
            .|   ...||:.::...|........|.:.|              |.........|...|.|:| 
Mouse   572 CD---AVESRDANICPQDCLRADIVGGHERG--------------ERQGIKAGYGICNCFPDEK- 618

  Fly   804 VTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENR------LDRIERSFTVVISDLPGISMAWV 862
                                         ||..|..      .|.:.|  |::.:.|        
Mouse   619 -----------------------------KCFCEPEDSQGPLCDALCR--TIITAAL-------- 644

  Fly   863 WFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEG------AVGHINPDL-TLDEQAE 920
             |.:|:.::|...||  ...::..||..:|..........:|      :.|...|.| :.:.|..
Mouse   645 -FSLIISILLSIFCV--CHHHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVP 706

  Fly   921 L----LPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVR 981
            :    :|.:.::||||:||.|||.||.|.||.|:|..|..::.....|||||||:|..|....:|
Mouse   707 VDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELR 771

  Fly   982 ALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDT 1046
            .|:||..::..: .|.:|:.|.||.:::   ..|::||||.::|:::.||..:||          
Mouse   772 DLLSEFNLLKQV-NHPHVIKLYGACSQD---GPLLLIVEYAKYGSLRGFLRDSRK---------- 822

  Fly  1047 DHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGT 1111
              |.|:.:              :|||                           .|||.:      
Mouse   823 --IGPAYV--------------SGGG---------------------------SRNSSS------ 838

  Fly  1112 RAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLIS 1176
                                                             .|..:...:|..||||
Mouse   839 -------------------------------------------------LDHPDERVLTMGDLIS 854

  Fly  1177 WAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWL 1241
            :|:|::|||.||:..|::|.||||||||:.|...:||.||||:|.:|..|:|.|...|::|:||:
Mouse   855 FAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWM 919

  Fly  1242 ALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYE 1306
            |:|||.||:::|.|||||:|::|||:.:|...|||||.| :.|||.|..|:|||:|...::|:|.
Mouse   920 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGHRMERPDNCSEEMYR 983

  Fly  1307 IMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYLALMGS-- 1369
            :||:||::.|:.||:||::.|                        ::|.|..:|.|||.|..|  
Mouse   984 LMLQCWKQEPDKRPVFADISK------------------------DLEKMMVKSRDYLDLAASTP 1024

  Fly  1370 ------PDELAPAAPRYVNGHIVPDIRIEELPDDYME-----MSRDSDPDACTAIFSP---TRLE 1420
                  .|.|:......|:.:..|..|  .||..::|     ||..:.|..     ||   ||.:
Mouse  1025 SDSLLYDDGLSEEETPLVDCNNAPLPR--SLPSTWIENKLYGMSDPNWPGE-----SPVPLTRAD 1082

  Fly  1421 GESSDFPDFSSETTF 1435
            |.|:.||.:::::.:
Mouse  1083 GTSTGFPRYANDSVY 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653
Ig strand C 363..366 CDD:409353
Ig strand E 396..400 CDD:409353
Ig strand F 410..415 CDD:409353
Ig strand G 425..428 CDD:409353
Ig 458..533 CDD:472250 20/85 (24%)
Ig strand B 459..463 CDD:409353 1/9 (11%)
Ig strand C 472..476 CDD:409353 0/3 (0%)
Ig strand E 497..503 CDD:409353 2/5 (40%)
Ig strand F 513..518 CDD:409353 0/4 (0%)
Ig 671..>742 CDD:472250 13/70 (19%)
Ig strand B 674..678 CDD:409353 0/3 (0%)
Ig strand C 687..691 CDD:409353 1/3 (33%)
Ig strand E 717..721 CDD:409353 1/3 (33%)
Ig strand F 731..736 CDD:409353 2/4 (50%)
Ig 779..851 CDD:472250 11/77 (14%)
Ig strand B 781..785 CDD:409570 0/3 (0%)
Ig strand C 794..798 CDD:409570 1/3 (33%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 2/4 (50%)
Ig strand G 844..847 CDD:409570 1/2 (50%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 136/404 (34%)
RetNP_033076.2 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949 29..153
Cadherin 173..262 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949 266..380 18/76 (24%)
RET_CLD3 266..380 CDD:465516 18/76 (24%)
Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949 407..508 23/128 (18%)
RET_CLD4 409..508 CDD:465517 23/126 (18%)
PTKc_RET 724..1013 CDD:173631 134/425 (32%)
Blue background indicates that the domain is not in the aligned region.

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