DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and zig-13

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_497161.1	Gene:	zig-13 / 188571	WormBaseID:	WBGene00020546	Length:	352	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	85/417 - (20%)
Similarity:	138/417 - (33%)	Gaps:	87/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 MLQVLNAQL-----------QDSGTYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVAR 553
            |:.:|||.:           |...|.:..|..||.:.:::                :...|:...
Worm     1 MIILLNALVISFFLKFVTTDQTPNTQIFVGPPSFSIFEQD----------------FYYPGTRLH 49

  Fly   554 LECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVS 618
            :||...|.||......:|...      |.|.:..|:......:          |.......|.||
Worm    50 IECLSISIPPETAFLEYRTKK------TGSFVRINYQRAISDD----------GTFDSGVFYNVS 98

  Fly   619 FLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHK-IAKEDNVNFTCEALA 682
            .  ||.....|..:    |:...:....||..|.......:.|..:..| :.::|.||..|....
Worm    99 L--TEDIEFLCWTR----GQGHPSFKHIHVADGPSKAFYNVGGAPRFQKSVYEQDTVNLFCAIPH 157

  Fly   683 YHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDR-GTYECRAYHNDKDAVYS 746
            ...:..:.|     .|:.|:|....:..|.....|..|:||:.:..: |.|.| ....||   :.
Worm   158 SAINWKVSW-----RLENSNSTSDLSVTTLIDGNSKYHVTTVKNITKSGVYTC-VIEADK---FK 213

  Fly   747 SREIDLYVHDPSAPQWTNGGQEGHSKI---KRKLSQTLELECASTAVPVAIVRWFKDDKEVTESK 808
            .|...|.......|..|.......||:   ..|.|..:|::|..|..|:....|..|:
Worm   214 ERRQLLETVIKVKPASTRPEPIKSSKMAIPNCKSSIEIEIQCNITGHPLPEYSWVTDE------- 271

  Fly   809 LRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILI 873
                 ...|.|.|:.    |.||::|:     |...|...|.::.....::.:.....:|..:.:
Worm   272 -----SSGSTLTISE----DSGVFQCI-----DSKNRYVEVNVTGSHRKALGFYIIVALLMSVTV 322

  Fly   874 GLCVFL---AVRYQKEHKRHLALKAAG 897
            |:||||   .|....|.||.:.....|
Worm   323 GVCVFLISERVANGTEKKRPVQYNLRG 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	9/43 (21%)
		IG_like	672..754	CDD:214653	20/82 (24%)
		Ig	674..739	CDD:143165	15/65 (23%)
		IGc2	779..840	CDD:197706	13/60 (22%)
		PKc_like	927..1332	CDD:304357
		Pkinase_Tyr	935..1329	CDD:285015
zig-13	NP_497161.1	IG_like	251..301	CDD:214653	16/70 (23%)
zig-13	NP_497161.1	Ig	251..289	CDD:299845	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900