DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and R151.1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001299880.1	Gene:	R151.1 / 187907	WormBaseID:	WBGene00020106	Length:	696	Species:	Caenorhabditis elegans

Alignment Length:	822	Identity:	176/822 - (21%)
Similarity:	290/822 - (35%)	Gaps:	278/822 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 RPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHK 667
            |||...|....::.:.  ||...|.|.:   |:||             |.|.|  |...:..|.|
Worm    52 RPRKDNLGDSHLFAMP--PTNVEIETKV---IMDG-------------GKILE--TTINWKADEK 96

  Fly   668 IAKEDN-------VNFTCEALAYHFDG-------------NLKWFINGEDL--KESDSVHIETSH 710
            ..:.:.       ||.||:.   ||.|             .:....||..|  ..|.|.|::...
Worm    97 DTRREGFYIRYTAVNSTCQK---HFPGYFTSSILPDERSLTIPSAFNGHALVIDHSCSYHLQIRA 158

  Fly   711 TKYSYKSTVHIT----TISDRDRGTYECR----AYHND--KDAVY---------SSREIDLYV-- 754
            ..|......:|.    |:.|.......||    |...|  .||.|         ..||...||
Worm   159 KPYPPGDDKYIIERRHTVPDCIDKYCSCRPGDVAAIRDVSVDAEYRLNWKFDEMKGREYQFYVDV 223

  Fly   755 -------------HDPSAPQWT-----NGGQEGHSKIKRKLSQTLELECASTAVP---VAIVRWF 798
                         .:|.:.::|     ....|..:|.....:.|.:.:......|   ..|..:.
Worm   224 YERIAMPLIKKKGSEPESEEYTFRIANADSYEISAKSAETSAHTYQYQLPFQFTPFQQYKISIFA 288

  Fly   799 KDDKEVTESKLRHIIE------KESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGI 857
            .||.......:.||..      ..|::..|...|...|          ..|.::..::.|.:
Worm   289 VDDSFCHNQDVFHIFNTTNATFSSSEIPKTTPIPEISG----------SAITKTTMLMESSI--- 340

  Fly   858 SMAWVWFGVILFLILIG----LC---VFLAVRYQKEH--KRHLALKAAGLANFEEGAVGHINPDL 913
                    :::|||::.    :|   |.|.:|.:|:.  |||..|....|:......:
Worm   341 --------LVIFLIVVACMSPICTMIVLLCLRRRKKEIKKRHHFLHRRSLSCSRHSII------- 390

  Fly   914 TLDEQAELL--PYNR-------EFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVK 969
                :..:|  |.|.       |:....:::.:|..:|.||||.|.||..:|...:  ...||||
Worm   391 ----ETNILYRPPNEVNGGTTGEWLIRGQDIVVGAVIGEGAFGQVFKGILRGPNGQ--VIPVAVK 449

  Fly   970 MVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRN 1034
            .:||.|.:|.....|.|:::|..:|||.|:|.:.|..   :.::...:|:||..:|:::::|...
Worm   450 QLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYC---MDEQLQCMIMEYVPYGDLKHYLQNM 511

  Fly  1035 RKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTH 1099
            ||
Worm   512 RK--------------------------------------------------------------- 513

  Fly  1100 RRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDST 1164
            .::||:                                                      ..||.
Worm   514 EKDSDS------------------------------------------------------AIDSK 524

  Fly  1165 EAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYK 1229
            |.::.|.        |:|.||.:|.|..::|.||||||||:....|:||.|||::|.    ..|.
Worm   525 EFLSFTN--------QIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRP----GVYI 577

  Fly  1230 KSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRM 1294
            |...|.:|::||:.|::.|:.:|..||||::|::|||:.:|...||..: .::::.|:|.:|.|:
Worm   578 KMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNV-ADKDILNQLTEGMRL 641

  Fly  1295 EKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGED 1336
            |:|...:.::|.:|..||....|.||.|..:..:...:...|
Worm   642 EQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKIEQIANVD 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	26/122 (21%)
		Ig	674..739	CDD:143165	20/87 (23%)
		IGc2	779..840	CDD:197706	11/69 (16%)
		PKc_like	927..1332	CDD:304357	97/404 (24%)
		Pkinase_Tyr	935..1329	CDD:285015	96/393 (24%)
R151.1	NP_001299880.1	PTKc	422..677	CDD:270623	95/389 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810